Evidence that endogenous interleukin-1 is involved in leukocyte migration in acute experimental inflammation in rats and mice

Both a monoclonal antibody and antisera specific for determinants unique to individual cloned helper T cell lines can substitute for antigen and antigen-presenting cells in the activation of T cells.

1983 • 654 citations

Neutrophil chemotactic factor produced by lipopolysaccharide (LPS)-stimulated human blood mononuclear leukocytes: partial characterization and separation from interleukin 1 (IL 1).

1987 • 613 citations

Warner-Lambert/Parke-Davis award lecture. Cytokine-mediated activation of vascular endothelium. Physiology and pathology.

1988 • 597 citations

Production of interleukin-8 by human dermal fibroblasts and keratinocytes in response to interleukin-1 or tumour necrosis factor.

1989 • 422 citations

Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in mice.

1990 • 404 citations

Molecular Cloning and Expression of Rat Interleukin-1α cDNA

1989 • 332 citations

Analysis of the suppression of IL-1 alpha and IL-1 beta production in human peripheral blood mononuclear adherent cells by a glucocorticoid hormone.

1988 • 259 citations

Leukotrienes augment interleukin 1 production by human monocytes.

1985 • 250 citations

Interleukin 1 receptor blockade attenuates the host inflammatory response.

1990 • 216 citations

C5a induction of human interleukin 1. Synergistic effect with endotoxin or interferon-gamma.

1987 • 195 citations

The release of leukotriene B4 during experimental inflammation

1983 • 168 citations

Simple, sensitive and specific bioassay of interleukin-1

1989 • 159 citations

Intraperitoneal injection of zymosan in mice induces pain, inflammation and the synthesis of peptidoleukotrienes and prostaglandin E2

1985 • 154 citations

Effect of cytokines on polymorphonuclear neutrophil infiltration in the mouse. Prostaglandin- and leukotriene-independent induction of infiltration by IL-1 and tumor necrosis factor.

1988 • 140 citations

Migration of neutrophils across endothelial monolayers is stimulated by treatment of the monolayers with interleukin-1 or tumor necrosis factor-alpha.

1989 • 135 citations

Glucocorticoids inhibit prostaglandin synthesis not only at the level of phospholipase A₂ but also at the level of cyclo‐oxygenase/PGE isomerase

1989 • 134 citations

Recombinant interleukin-1 and tumor necrosis factor induce neutrophil migration “in vivo” by indirect mechanisms

1990 • 133 citations

Interleukin 1: a common endogenous mediator of inflammation and the local Shwartzman reaction.

1986 • 119 citations

Tumor necrosis factor and interleukin-1: role in acute inflammation and microvascular injury.

1987 • 119 citations

Evidence that neutrophil accumulation induced by interleukin‐1 requires both local protein biosynthesis and neutrophil CD18 antigen expression in vivo

1988 • 118 citations

IL-1 beta is secreted by activated murine macrophages as biologically inactive precursor.

1990 • 100 citations

The sequential generation of neutrophil chemoattractant proteins in acute inflammation in the rabbit in vivo. Relationship between C5a and proteins with the characteristics of IL-8/neutrophil-activating protein 1.

1991 • 94 citations

Presence of IL-1 receptors on human and murine neutrophils. Relevance to IL-1-mediated effects in inflammation.

1989 • 52 citations

Kinetics of the generation and action of chemical mediators in zymosan‐induced inflammation of the rabbit peritoneal cavity

1986 • 43 citations

Generation of an interleukin-I-like lymphocyte-stimulating factor at inflammatory sites: correlation with the infiltration of polymorphonuclear leucocytes.

1984 • 40 citations

Kinetics of phospholipase A2, arachidonic acid, and eicosanoid appearance in mouse zymosan peritonitis.

1990 • 33 citations

The effect of adrenalectomy on interleukin‐1 release in vitro and in vivo

1989 • 30 citations

Modulation of phospholipase A₂ activity in human fibroblasts

1989 • 29 citations

Biological activity of recombinant murine interleukin-6 in interleukin-1 T cell assays

1989 • 28 citations

Recombinant interleukin-1? interacts with high-affinity receptors to activate neutrophil leukotriene B4 synthesis

1990 • 26 citations

Studies on cell motility in inflammation. I. The chemotactic activity of experimental, immunological and non-immunological, inflammatory exudates

1979 • 25 citations

Different pro-inflammatory profiles of interleukin 1 (IL 1) and tumor necrosis factor (TNF) in anin vivo model of inflammation

1989 • 24 citations

Leukotrienes do not regulate interleukin 1 production by activated macrophages

1990 • 23 citations

Chemotactic activity of recombinant human interleukin-1

1987 • 21 citations

Pharmacological studies on zymosan inflammation in rats and mice. 2: Zymosan-induced pleurisy in rats

1989 • 15 citations

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