JNK Regulates Autocrine Expression of TGF-β1

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Smad-dependent and Smad-independent pathways in TGF-β family signalling

2003 • 5,052 citations

Signal Transduction by the JNK Group of MAP Kinases

2000 • 4,096 citations

A rapid micrqpreparation technique for extraction of DNA-binding proteins from limiting numbers of mammalian cells

1991 • 2,362 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway

2000 • 1,703 citations

Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development

1998 • 1,551 citations

Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization

1998 • 1,248 citations

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

1999 • 912 citations

Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription

1998 • 789 citations

Growth Inhibitor from BSC-1 Cells Closely Related to Platelet Type β Transforming Growth Factor

1984 • 779 citations

Regulation of fibronectin and type I collagen mRNA levels by transforming growth factor-beta.

1987 • 736 citations

TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells.

1996 • 680 citations

TGF-beta induces fibronectin synthesis through a c-Jun N-terminal kinase-dependent, Smad4-independent pathway

1999 • 667 citations

Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex.

1990 • 647 citations

Targeting JNK for therapeutic benefit: from junk to gold?

2003 • 575 citations

Control of cell cycle progression by c-Jun is p53 dependent

1999 • 562 citations

Interdependent SMAD and JNK Signaling in Transforming Growth Factor-β-mediated Transcription

1999 • 534 citations

Cell adhesion protein receptors as targets for transforming growth factor-$beta; action

1987 • 498 citations

TGFβ influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b

2001 • 479 citations

The Bax Subfamily of Bcl2-Related Proteins Is Essential for Apoptotic Signal Transduction by c-Jun NH₂-Terminal Kinase

2002 • 463 citations

Comparison of VEGF, VEGF-B, VEGF-C and Ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia

1997 • 459 citations

TGF-β1 inhibition of transin/stromelysin gene expression is mediated through a fos binding sequence

1990 • 444 citations

Characterization of the Promoter Region of the Human Transforming Growth Factor-β1 Gene

1989 • 400 citations

Transforming growth factor-β regulates production of proteoglycans by mesangial cells

1990 • 365 citations

TGF-β-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation

2001 • 350 citations

Effects of platelet-derived growth factor and transforming growth factor-beta 1 on the synthesis of a large versican-like chondroitin sulfate proteoglycan by arterial smooth muscle cells.

1991 • 331 citations

Transforming growth factor-beta 1 up-regulates type IV collagenase expression in cultured human keratinocytes

1991 • 307 citations

Evidence for a Role of Rho-like GTPases and Stress-activated Protein Kinase/c-Jun N-terminal Kinase (SAPK/JNK) in Transforming Growth Factor β-mediated Signaling

1997 • 301 citations

Cellular Transformation and Malignancy Induced by ras Require c-jun

1996 • 283 citations

Promoter Sequences of the Human Transforming Growth Factor-β1 Gene Responsive to Transforming Growth Factor-β1 Autoinduction

1989 • 254 citations

JunD Mediates Survival Signaling by the JNK Signal Transduction Pathway

2003 • 253 citations

Differential effects of transforming growth factor-beta on the synthesis of extracellular matrix proteins by normal fetal rat calvarial bone cell populations.

1988 • 238 citations

Elucidation of Smad Requirement in Transforming Growth Factor-β Type I Receptor-induced Responses

2003 • 209 citations

Activation of the second promoter of the transforming growth factor-β1 gene by transforming growth factor-β1 and phorbol ester occurs through the same target sequences

1989 • 185 citations

Smad3/AP-1 interactions control transcriptional responses to TGF-β in a promoter-specific manner

2001 • 180 citations

Tumor Necrosis Factor-α Inhibits Transforming Growth Factor-β /Smad Signaling in Human Dermal Fibroblasts via AP-1 Activation

2000 • 172 citations

MEKK-1, a Component of the Stress (Stress-activated Protein Kinase/c-Jun N-terminal Kinase) Pathway, Can Selectively Activate Smad2-mediated Transcriptional Activation in Endothelial Cells

1999 • 171 citations

Requirement of Ras/MAPK Pathway Activation by Transforming Growth Factor β for Transforming Growth Factor β1Production in a Smad-dependent Pathway

2000 • 163 citations

c-Jun NH₂-Terminal Kinase Is Essential for the Regulation of AP-1 by Tumor Necrosis Factor

2003 • 163 citations

JNK phosphorylation relieves HDAC3-dependent suppression of the transcriptional activity of c-Jun

2003 • 148 citations

Type beta transforming growth factor from feline sarcoma virus-transformed rat cells. Isolation and biological properties.

1984 • 143 citations

Suppression of Ras-stimulated transformation by the JNK signal transduction pathway

2003 • 141 citations

Characterization of the mouse transforming growth factor-beta 1 promoter and activation by the Ha-ras oncogene.

1991 • 131 citations

Transforming growth factor β alters plasminogen activator activity in human skin fibroblasts

1986 • 114 citations

Role of AP-1 and HIF-1 Transcription Factors in TGF-β Activation of VEGF Expression

2001 • 107 citations

Structural and Functional Characterization of the Transforming Growth Factor-β-induced Smad3/c-Jun Transcriptional Cooperativity

2000 • 105 citations

Evidence for a Role of the JNK Cascade in Smad7-mediated Apoptosis

2001 • 102 citations

c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity

2001 • 100 citations

A Central Role for the JNK Pathway in Mediating the Antagonistic Activity of Pro-inflammatory Cytokines against Transforming Growth Factor-β-driven SMAD3/4-specific Gene Expression

2003 • 90 citations

JNK initiates a cytokine cascade that causes Pax2 expression and closure of the optic fissure

2003 • 88 citations

c-Jun Inhibits Transforming Growth Factor β-mediated Transcription by Repressing Smad3 Transcriptional Activity

2000 • 86 citations

Transforming growth factor β1 inhibits collagenase 3 expression by transcriptional and post-transcriptional mechanisms in osteoblast cultures

1997 • 59 citations

c-Jun Associates with the Oncoprotein Ski and Suppresses Smad2 Transcriptional Activity

2002 • 53 citations

Effect of transforming growth factors‐β on collagen type VI expression in human dermal fibroblasts

1992 • 38 citations

Transforming Growth Factor-β Inhibition of Insulin-like Growth Factor-binding Protein-5 Synthesis in Skeletal Muscle Cells Involves a c-Jun N-terminal Kinase-dependent Pathway

2001 • 31 citations