Use-dependent block of cardiac sodium channels by quaternary derivatives of lidocaine

A quantitative description of membrane current and its application to conduction and excitation in nerve

1952 • 21,965 citations

The Pharmacological Basis for Therapeutics

1981 • 1,896 citations

Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction.

1977 • 1,746 citations

Time- and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels

1977 • 899 citations

The variance of sodium current fluctuations at the node of Ranvier

1980 • 772 citations

The effect of the cardiac membrane potential on the rapid availability of the sodium‐carrying system

1955 • 763 citations

Effects of calcium ions and local anaesthetics on electrical properties of Purkinje fibres

1955 • 708 citations

The Inhibition of Sodium Currents in Myelinated Nerve by Quaternary Derivatives of Lidocaine

1973 • 660 citations

The electrical constants of Purkinje fibres

1952 • 628 citations

The steady state TTX-sensitive (?window?) sodium current in cardiac Purkinje fibres

1979 • 468 citations

Mechanism of frequency-dependent inhibition of sodium currents in frog myelinated nerve by the lidocaine derivative GEA.

1975 • 387 citations

Slow recovery from inactivation of inward currents in mammalian myocardial fibres

1974 • 325 citations

Sodium current in single rat heart muscle cells.

1981 • 324 citations

Fast sodium current in cardiac muscle. A quantitative description

1980 • 253 citations

Effect of tetrodotoxin on action potentials of the conducting system in the dog heart

1979 • 241 citations

Effect of lidocaine and quinidine on steady-state characteristics and recovery kinetics of (dV/dt)max in guinea pig ventricular myocardium.

1975 • 206 citations

Local anesthetic block of sodium channels in normal and pronase-treated squid giant axons

1978 • 204 citations

Voltage clamp technique in mammalian cardiac fibres

1964 • 203 citations

Effect of Altering Potassium Concentration on the Action of Lidocaine and Diphenylhydantoin on Rabbit Atrial and Ventricular Muscle

1971 • 185 citations

Tetrodotoxin block of sodium channels in rabbit Purkinje fibers. Interactions between toxin binding and channel gating.

1981 • 184 citations

Shortening of the action potential and reduction of pacemaker activity by lidocaine, quinidine, and procainamide in sheep cardiac purkinje fibers. An effect on Na or K currents?

1982 • 175 citations

Two levels of resting potential in cardiac Purkinje fibers.

1977 • 175 citations

Voltage clamp measurements of sodium channel properties in rabbit cardiac Purkinje fibres.

1980 • 154 citations

The differential effect of quinidine and pyrilamine on the myocardial action potential at various rates of stimulation.

1957 • 150 citations

Test of a model of antiarrhythmic drug action. Effects of quinidine and lidocaine on myocardial conduction.

1980 • 142 citations

Sodium channels need not open before they inactivate

1981 • 141 citations

Interval-dependent effects of small antiarrhythmic drugs on excitability of guinea-pig myocardium

1980 • 138 citations

The initial inward current in spherical clusters of chick embryonic heart cells.

1980 • 123 citations

Amiodarone blocks inactivated cardiac sodium channels

1983 • 120 citations

Mechanism of action of antifibrillatory drugs

1971 • 116 citations

Sodium channel inactivation in the crayfish giant axon. Must channels open before inactivating?

1981 • 98 citations

Sodium inactivation mechanism modulates QX-314 block of sodium channels in squid axons

1978 • 96 citations

Inactivation of the sodium permeability in squid giant nerve fibres

1979 • 88 citations

The relation of Vmax to INa, GNa, and h infinity in a model of the cardiac Purkinje fiber

1979 • 81 citations

PH-Dependent effects of quinidine on the kinetics of dV/dtmax in guinea pig ventricular myocardium.

1982 • 79 citations

On the voltage-dependent action of tetrodotoxin

1977 • 75 citations

The influence of pH on th electrophysiological effects of lidocaine in guinea pig ventricular myocardium.

1980 • 72 citations

Frequency-dependent Conduction Block

1978 • 64 citations

Effect of lidocaine on the early inward transient current in sheep cardiac Purkinje fibers.

1975 • 64 citations

Tonic and phasicI Na blockade by antiarrhythmics

1983 • 63 citations

The influence of molecular form of local anesthetic-type antiarrhythmic agents on reduction of the maximum upstroke velocity of canine cardiac Purkinje fibers.

1983 • 52 citations

The dependence of the maximum rate of rise of the action potential upstroke on membrane properties

1981 • 51 citations

Mechanisms of quinidine-induced depression of maximum upstroke velocity in ovine cardiac Purkinje fibers.

1982 • 49 citations

Antiarrhythmic Drugs: Electrophysiological and Pharmacokinetic Considerations

1975 • 43 citations

Effects of extracellular calcium ions, verapamil, and lanthanum on active and passive properties of canine cardiac purkinje fibers.

1982 • 43 citations

Sites of action and active forms of lidocaine and some derivatives on cardiac Purkinje fibers.

1978 • 28 citations

Voltage-clamp studies on the canine Purkinje strand

1983 • 19 citations

A Specific Effect of Lidocaine and Tocainide on Ventricular Conduction of Mid-Range Extrasystoles

1979 • 14 citations