A paradigm for restenosis based on cell biology: Clues for the development of new preventive therapies

Angiogenic Factors

1987 • 3,702 citations

Transforming growth factor-beta stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix.

1986 • 2,499 citations

The biology of platelet-derived growth factor

1986 • 2,036 citations

The Molecular and Cellular Biology of Wound Repair

1988 • 1,508 citations

Kinetics of cellular proliferation after arterial injury. I. Smooth muscle growth in the absence of endothelium.

1983 • 1,441 citations

Restenosis after percutaneous transluminal coronary angioplasty (PTCA): A report from the PTCA registry of the national heart, lung, and blood institute

1984 • 1,122 citations

Inhibitors of Angiotensin-Converting Enzyme Prevent Myointimal Proliferation After Vascular Injury

1989 • 1,061 citations

Incidence of restenosis after successful coronary angioplasty: a time-related phenomenon. A quantitative angiographic study in 342 consecutive patients at 1, 2, 3, and 4 months.

1988 • 936 citations

Restenosis after coronary angioplasty. Potential biologic determinants and role of intimal hyperplasia.

1989 • 935 citations

Dual control of cell growth by somatomedins and platelet-derived growth factor.

1979 • 926 citations

Restenosis After Successful Percutaneous Transluminal Coronary Angioplasty: Serial Angiographic Follow-Up of 229 Patients

1988 • 893 citations

Turbulent fluid shear stress induces vascular endothelial cell turnover in vitro.

1986 • 835 citations

Replication of smooth muscle cells in vascular disease.

1986 • 770 citations

Mechanisms of stenosis after arterial injury.

1983 • 765 citations

Syndromes of accelerated atherosclerosis: Role of vascular injury and smooth muscle cell proliferation

1990 • 765 citations

Cyclic Stretching Stimulates Synthesis of Matrix Components by Arterial Smooth Muscle Cells in Vitro

1976 • 701 citations

Aspirin and Dipyridamole in the Prevention of Re-Stenosis after Percutaneous Transluminal Coronary Angioplasty

1988 • 696 citations

Cultured endothelial cells produce heparinlike inhibitor of smooth muscle cell growth

1981 • 685 citations

Enhancement of Wound Healing by Topical Treatment with Epidermal Growth Factor

1989 • 673 citations

Balloon angioplasty. Natural history of the pathophysiological response to injury in a pig model.

1985 • 633 citations

Induction of platelet-derived growth factor A-chain and c-myc gene expressions by angiotensin II in cultured rat vascular smooth muscle cells.

1989 • 632 citations

Intimal proliferation of smooth muscle cells as an explanation for recurrent coronary artery stenosis after percutaneous transluminal coronary angioplasty

1985 • 586 citations

Significance of quiescent smooth muscle migration in the injured rat carotid artery.

1985 • 570 citations

Classification and Treatment of Chronic Nonhealing Wounds

1986 • 521 citations

Morphology after Transluminal Angioplasty in Human Beings

1981 • 484 citations

Endothelial regeneration in the rat carotid artery and the significance of endothelial denudation in the pathogenesis of myointimal thickening.

1975 • 472 citations

Immunodetection and quantitation of the two forms of transforming growth factor‐beta (TGF‐β1 and TGF‐β2) secreted by cells in culture

1989 • 453 citations

Medicine and the Law

1983 • 440 citations

Role of platelets in smooth muscle cell proliferation and migration after vascular injury in rat carotid artery.

1989 • 420 citations

Transforming growth factor beta regulates the expression and structure of extracellular matrix chondroitin/dermatan sulfate proteoglycans.

1988 • 418 citations

Cell biology of arterial proteoglycans.

1989 • 409 citations

Production of platelet-derived growth factor-like molecules by cultured arterial smooth muscle cells accompanies proliferation after arterial injury.

1986 • 393 citations

Reduction in the Rate of Early Restenosis after Coronary Angioplasty by a Diet Supplemented with n–3 Fatty Acids

1988 • 385 citations

Coumadin and aspirin in prevention of recurrence after transluminal coronary angioplasty: a randomized study.

1984 • 363 citations

Mechanisms of arterial graft healing. Rapid transmural capillary ingrowth provides a source of intimal endothelium and smooth muscle in porous PTFE prostheses.

1986 • 352 citations

Significance of quiescent smooth muscle migration in the injured rat carotid artery.

1985 • 342 citations

“Crackers, breakers, stretchers, drillers, scrapers, shavers, burners, welders and melters”—the future treatment of atherosclerotic coronary disease? A clinical-morphologic assessment

1989 • 321 citations

Endothelial regeneration. III. Time course of intimal changes after small defined injury to rat aortic endothelium.

1981 • 316 citations

Platelet accumulation in experimental angioplasty: time course and relation to vascular injury.

1987 • 296 citations

Kinetics of cellular proliferation after arterial injury. III. Endothelial and smooth muscle growth in chronically denuded vessels.

1986 • 281 citations

Transforming Growth Factor β: Biochemistry and Roles in Embryogenesis, Tissue Repair and Remodeling, and Carcinogenesis

1988 • 255 citations

A controlled trial of corticosteroids to prevent restenosis after coronary angioplasty. M-HEART Group.

1990 • 252 citations

Arterial smooth muscle. A multifunctional mesenchymal cell.

1988 • 238 citations

Transforming growth factor-beta activity is potentiated by heparin via dissociation of the transforming growth factor-beta/alpha 2-macroglobulin inactive complex.

1989 • 225 citations

Transluminal atherectomy for occlusive peripheral vascular disease

1988 • 224 citations

RANDOMISED TRIAL OF FISH OIL FOR PREVENTION OF RESTENOSIS AFTER CORONARY ANGIOPLASTY

1989 • 223 citations

A perspective of coronary disease seen through the arteries of living man.

1987 • 208 citations

A reassessment of endothelial injury and arterial lesion formation.

1985 • 198 citations

Transforming growth factor type beta specifically stimulates synthesis of proteoglycan in human adult arterial smooth muscle cells.

1987 • 198 citations

Induction of insulin-like growth factor I messenger RNA in rat aorta after balloon denudation.

1990 • 195 citations

Kinetics of cellular proliferation after arterial injury. II. Inhibition of smooth muscle growth by heparin.

1985 • 195 citations

Role of platelets and thrombosis in mechanisms of acute occlusion and restenosis after angioplasty

1987 • 194 citations

The mechanism of transluminal angioplasty: evidence for formation of aneurysms in experimental atherosclerosis.

1983 • 182 citations

Intimal hyperplasia as a cause of restenosis after percutaneous transluminal coronary angioplasty.

1985 • 168 citations

Transforming growth factor β levels in rat wound chambers

1987 • 161 citations

Relation of acute myocardial infarction to cocaine abuse

1985 • 158 citations

Importance of stenosis morphology in the estimation of restenosis risk after elective percutaneous transluminal coronary angioplasty

1989 • 155 citations

The calcium antagonist nifedipine inhibits arterial smooth muscle cell proliferation

1985 • 154 citations

Angioscopic observation of the coronary luminal changes induced by percutaneous transluminal coronary angioplasty

1989 • 152 citations

Histopathologic phenomena at the site of percutaneous transluminal coronary angioplasty: The problem of restenosis

1989 • 148 citations

Cyclosporin A inhibits smooth muscle proliferation in the vascular response to injury.

1988 • 145 citations

Restenosis after successful percutaneous transluminal coronary angioplasty: The montreal heart institute experience

1987 • 138 citations

Balloon catheter injury to rabbit carotid artery. I. Changes in smooth muscle phenotype.

1989 • 131 citations

Modulation of sulfated proteoglycan synthesis by bovine aortic endothelial cells during migration.

1986 • 131 citations

Inhibitory effect of calcium antagonists on balloon catheter-induced arterial smooth muscle cell proliferation and lesion size

1988 • 127 citations

Kinetics of cellular proliferation after arterial injury. V. Role of acute distension in the induction of smooth muscle proliferation.

1989 • 124 citations

Growth Factors and Other Aspects of Wound Healing: Biological and Clinical Implications

1989 • 124 citations

Prostaglandin E1 inhibits DNA synthesis in arterial smooth muscle cells stimulated with platelet-derived growth factor

1984 • 123 citations

Effects of percutaneous transluminal coronary angioplasty on atherosclerotic plaques and relation of plaque composition and arterial size to outcome

1988 • 122 citations

Endothelial Cell Influences on Vascular Smooth Muscle Phenotype

1986 • 109 citations

Arterial changes after percutaneous transluminal coronary angioplasty: Results at autopsy

1987 • 107 citations

Regulation of Vascular Smooth Muscle Cell Growth by Heparin and Heparan Sulfates

1987 • 106 citations

Rate of Chondroitin Sulfate Formation in Wound Healing

1967 • 94 citations

The disease-free wall in coronary atherosclerosis: Its relation to degree of obstruction

1985 • 86 citations

Pathological findings after percutaneous transluminal coronary angioplasty.

1984 • 85 citations

Measurement of collagen biosynthesis during wound healing

1975 • 79 citations

Antiatherogenic activity of FR34235 (Nilvadipine), a new potent calcium antagonist

1987 • 79 citations

Arterial Regeneration Over Polydioxanone Prostheses in the Rabbit

1987 • 79 citations

Cell cycle-dependent inhibition of DNA synthesis by prostaglandin I2 in cultured rabbit aortic smooth muscle cells

1988 • 77 citations

Kinetics of cellular proliferation after arterial injury II. Inhibition of smooth muscle growth by heparin

1986 • 77 citations

Retinoid effects on fibroblast proliferation and collagen synthesis in vitro and on fibrotic disease in vivo

1986 • 76 citations

EPIDERMAL GROWTH FACTOR AND RELATED MOLECULES

1989 • 76 citations

Clinical applications of heparin‐binding growth factors

1988 • 76 citations

Immediate and long-term effects of angioplasty-balloon dilation on normal rabbit iliac artery.

1986 • 72 citations

Coronary arterial findings after accidental death immediately after successful percutaneous transluminal coronary angioplasty

1985 • 71 citations

Retinoic Acid in the Treatment of Keloids

1988 • 62 citations

Pathological changes induced by repeated percutaneous transluminal coronary angioplasty.

1987 • 61 citations

Relation to restenosis after percutaneous transluminal coronary angioplasty to vasomotion of the dilated coronary arterial segment

1989 • 60 citations

FIBRONECTIN IN EXPERIMENTAL GRANULATION TISSUE

1982 • 58 citations

Epidermal growth factor and related molecules.

1989 • 57 citations

Accelerated coronary arteriosclerosis in cardiac transplant recipients

1987 • 53 citations

Glycosaminoglycans in corneal regeneration

1961 • 52 citations

Inhibition of vascular smooth muscle cell proliferation in culture by pentosan polysulphate and related compounds

1987 • 49 citations

Somatomedins: do they play a pivotal role in wound healing?

1988 • 48 citations

Morphologic correlates of coronary angiographic patterns at the site of percutaneous transluminal coronary angioplasty

1988 • 47 citations

Platelet deposition at angioplasty sites and its relation to restenosis in human iliac and femoropopliteal arteries.

1989 • 43 citations

Paralysis of arteries by intraluminal balloon dilatation.

1982 • 39 citations

Morphological aspects of secretion in the arterial smooth muscle cell, with special reference to the golgi complex and microtubular cytoskeleton

1986 • 38 citations

Coronary artery restenosis following transluminal coronary angioplasty.

1986 • 36 citations

Glycosaminoglycan composition and biosynthesis in the endothelium-covered neointima of de-endothelialized rabbit aorta

1985 • 33 citations

Percutaneous Transluminal Coronary Angioplasty:

1985 • 25 citations

Inhibitory effect of dimethyl sulfoxide on the proliferation of cultured arterial smooth muscle cells: Relationship to the cytoplasmic microtubules

1988 • 23 citations

Effect of Cortisol on the Proliferation and Protein Synthesis of Human Aortic Smooth Muscle Cells in Culture

1982 • 22 citations

The effects of different growth factors in subcutaneous wound chambers.

1988 • 13 citations

Growth factors: soluble mediators of wound repair and ocular fibrosis.

1988 • 7 citations