Mucosal inflammatory cytokine production by intestinal biopsies in patients with ulcerative colitis and Crohn's disease

Cortisone in Ulcerative Colitis

1955 • 2,701 citations

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

1994 • 1,129 citations

Treatment of Crohn's disease with anti-tumor necrosis factor chimeric monoclonal antibody (cA2)

1995 • 1,103 citations

Enhand secretion of tumour necrosis factor-alpha, IL-6, and IL-1β by isolated lamina ropria monouclear cells from patients with ulcretive cilitis and Crohn's disease

1993 • 848 citations

Regulatory interactions between CD45RBhigh and CD45RBlow CD4+ T cells are important for the balance between protective and pathogenic cell-mediated immunity.

1994 • 630 citations

Tumor necrosis factor α-producing cells in the intestinal mucosa of children with inflammatory bowel disease

1994 • 578 citations

Microscopic activity in ulcerative colitis: what does it mean?

1991 • 544 citations

Location of tumour necrosis factor alpha by immunohistochemistry in chronic inflammatory bowel disease.

1993 • 532 citations

Cortisone in Ulcerative Colitis

1954 • 524 citations

Tumour necrosis factor-alpha and interferon-gamma production measured at the single cell level in normal and inflamed human intestine

1990 • 489 citations

Enhanced production of interleukin 1-beta by mononuclear cells isolated from mucosa with active ulcerative colitis of Crohn's disease.

1989 • 430 citations

Isolation and functional characterization of human intestinal mucosal lymphoid cells.

1977 • 403 citations

Role of interleukin 1 in inflammatory bowel disease--enhanced production during active disease.

1990 • 402 citations

Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel disease. A novel mechanism of chronic intestinal inflammation.

1995 • 400 citations

An index of inflammatory activity in patients with Crohn's disease.

1980 • 340 citations

Tumor necrosis factor-?, interleukin-1?, and interleukin-6 expression in inflammatory bowel disease

1992 • 325 citations

Cytokine messenger RNA profiles in inflammatory bowel disease mucosa detected by polymerase chain reaction amplification

1992 • 323 citations

Localization of intestinal interleukin 1 activity and protein and gene expression to lamina propria cells

1993 • 196 citations

Recombinant interleukin-1 receptor antagonist blocks the proinflammatory activity of endogenous interleukin-1 in rabbit immune colitis

1992 • 189 citations

Increased concentrations of interleukin 1 beta, interleukin-2, and soluble interleukin-2 receptors in endoscopical mucosal biopsy specimens with active inflammatory bowel disease.

1992 • 169 citations

Elevation of interleukin-6 in inflammatory bowel disease is macrophage- and epithelial cell-dependent

1995 • 148 citations

Monoclonal antibodies to human recombinant interleukin 1 (IL 1)beta: quantitation of IL 1 beta and inhibition of biological activity.

1987 • 115 citations

Impaired response of activated mononuclear phagocytes to interleukin 4 in inflammatory bowel disease

1995 • 109 citations

Colonic Mucosal Interleukin-6 in Inflammatory Bowel Disease

1991 • 104 citations

Cytokine mRNA Expression in Intestine from Normal and Inflammatory Bowel Disease Patients

1993 • 80 citations

Cytokine messenger RNA expression and proliferation status of intestinal mononuclear cells in noninflamed gut and Crohn's disease

1995 • 58 citations

Use of coculture of colonic mucosal biopsies to investigate the release of eicosanoids by inflamed and uninflamed mucosa from patients with inflammatory bowel disease.

1992 • 50 citations

Colonic Mucosal Interleukin 1 Receptor Antagonist in Inflammatory Bowel Disease

1994 • 44 citations

Is macrophage death on the field of battle essential to victory, or a tactical weakness in immunity against tuberculosis?

1990 • 22 citations

Cytokine production in the mucosa of patients with inflammatory bowel disease

1993 • 6 citations