Androgens and bone

Estrogen Resistance Caused by a Mutation in the Estrogen-Receptor Gene in a Man

1994 • 2,443 citations

Involutional Osteoporosis

1986 • 1,873 citations

Increased Osteoclast Development After Estrogen Loss: Mediation by Interleukin-6

1992 • 1,437 citations

The Parathyroid Glands and Metabolic Bone Disease

1949 • 921 citations

Sexual Dimorphism in the Control of Growth Hormone Secretion*

1985 • 749 citations

Effects of testosterone supplementation in the aging male.

1992 • 714 citations

17 beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens.

1992 • 685 citations

Risk factors for spinal osteoporosis in men

1983 • 665 citations

Testosterone Secretion and Metabolism in Male Senescence

1972 • 543 citations

Identification of androgen receptors in normal human osteoblast-like cells.

1989 • 464 citations

Epidemiology of Fractures of the Proximal Femur in Rochester, Minnesota

1980 • 449 citations

Castrated Men Exhibit Bone Loss: Effect of Calcitonin Treatment on Biochemical Indices of Bone Remodeling*

1989 • 439 citations

Osteopenia in Men with a History of Delayed Puberty

1992 • 433 citations

ANDROGENS DIRECTLY STIMULATE PROLIFERATION OF BONE CELLS IN VITRO

1989 • 404 citations

Avian osteoclasts as estrogen target cells.

1991 • 394 citations

Increases in Bone Density During Treatment of Men with Idiopathic Hypogonadotropic Hypogonadism*

1989 • 355 citations

Does Hypogonadism Contribute to the Occurrence of a Minimal Trauma Hip Fracture in Elderly Men?

1991 • 271 citations

Effect of body weight on osteopenia in ovariectomized rats

1987 • 259 citations

Osteoporosis in Men with Hyperprolactinemic Hypogonadism

1986 • 258 citations

Differential effects of androgens on cortical bone histomorphometry in gonadectomized male and female rats

1990 • 238 citations

Bone and mineral metabolism in aged male rats: short and long term effects of androgen deficiency.

1992 • 218 citations

Osteoporosis in hypogonadal men: Role of decreased plasma 1,25-dihydroxyvitamin D, calcium malabsorption, and low bone formation

1986 • 218 citations

Bone Histomorphometry in Hypogonadal and Eugonadal Men with Spinal Osteoporosis*

1987 • 205 citations

The Impact of Gonadal Steroid Hormone Action on Growth Hormone Secretion During Childhood and Adolescence*

1992 • 203 citations

Androgen treatment prevents loss of cancellous bone in the orchidectomized rat

1991 • 202 citations

Differential effects of gonadal function on bone histomorphometry in male and female rats

1989 • 197 citations

Sex hormones and bone mineral density in elderly men

1993 • 197 citations

Androgen-stimulated pubertal growth: the effects of testosterone and dihydrotestosterone on growth hormone and insulin-like growth factor-I in the treatment of short stature and delayed puberty.

1993 • 197 citations

Serum Bone Gla-Protein as a Marker of Bone Growth in Children and Adolescents: Correlation With Age, Height, Serum Insulin-Like Growth Factor I, and Serum Testosterone*

1988 • 188 citations

Effects of Prolactin and Estrogen Deficiency in Amenorrheic Bone Loss*

1988 • 181 citations

Sex Steroids and Bone Density in Premenopausal and Perimenopausal Women

1989 • 175 citations

Studies of the Mechanism by which Androgens Enhance Mitogenesis and Differentiation in Bone Cells*

1990 • 170 citations

The Relation between Calcium Absorption, Serum Dehydroepiandrosterone, and Vertebral Mineral Density in Postmenopausal Women

1985 • 169 citations

CHANGES IN SKELETAL MASS AND FRAGILITY WITH CASTRATION IN THE RAT: A MODEL OF OSTEOPOROSIS*

1969 • 167 citations

Decreased bone density in elderly men treated with the gonadotropin-releasing hormone agonist decapeptyl (D-Trp6-GnRH).

1993 • 164 citations

Direct Modulation by Androgens of the Response of Human Bone Cells (SaOS-2) to Human Parathyroid Hormone (PTH) and PTH-Related Protein*

1989 • 159 citations

Effects of castration on the bone structure of male rats: A model of osteoporosis

1980 • 153 citations

Osteoporosis and Klinefelter's syndrome

1992 • 152 citations

Somatomedin-C in Normal Puberty and in True Precocious Puberty before and after Treatment with a Potent Luteinizing Hormone-Releasing Hormone Agonist*

1985 • 149 citations

Evaluation of the Pathogenesis of Skeletal Changes in Ovariectomized Rats*

1984 • 149 citations

High-Affinity Androgen Binding and Androgenic Regulation of α1(I)-Procollagen and Transforming Growth Factor-β Steady State Messenger Ribonucleic Acid Levels in Human Osteoblast-Like Osteosarcoma Cells*

1991 • 145 citations

Androgen receptors in osteoblast-like cell lines

1991 • 140 citations

Total and Free Estrogens and Androgens in Postmenopausal Women with Hip Fractures*

1982 • 137 citations

Marked Decline in Trabecular Bone Mineral Content in Healthy Men with Age: Lack of Association with Sex Steroid Levels

1987 • 136 citations

Failure of Estrogens and Androgens to Inhibit Bone Resorption in Tissue Culture

1976 • 129 citations

Estrogen synthesis by osteoblast cell lines.

1992 • 126 citations

The Pubertal Growth Spurt in Eight Patients with True Precocious Puberty and Growth Hormone Deficiency: Evidence for a Direct Role of Sex Steroids^*

1990 • 125 citations

Testosterone and Oxandrolone, a Nonaromatizable Androgen, Specifically Amplify the Mass and Rate of Growth Hormone (GH) Secreted per Burst without Altering GH Secretory Burst Duration or Frequency or the GH Half-Life*

1990 • 125 citations

Effect of Excess Endogenous Androgens on Bone Density in Young Women

1988 • 119 citations

Bone and mineral metabolism in the androgen-resistant (testicular feminized) male rat

1993 • 109 citations

Testosterone metabolism in human bone

1980 • 105 citations

Comparison of the Anabolic Effects of Synthetic Parathyroid Hormone-Related Protein (PTHrP) 1–34 and PTH 1–34 on Bone in Rats*

1989 • 105 citations

Low bone mass in hypogonadal males. Effect of testosterone substitution therapy, a densitometric study

1992 • 102 citations

Osteoporosis and Decline of Gonadal Function in the Elderly Male

1984 • 102 citations

Androstenedione metabolism in cultured human osteoblast-like cells.

1992 • 99 citations

Loss of bone mass in patients with Klinefelter's syndrome despite sufficient testosterone replacement

1993 • 90 citations

Immunocytochemical identification of androgen receptor in mouse osteoclast-like multinucleated cells

1994 • 85 citations

Long-term effect of orchidectomy on cortical bone from rat femur: Bone mass and mechanical properties

1992 • 84 citations

Aromatase activity in human osteoblast-like osteosarcoma cell

1993 • 82 citations

Endogenous cortisol and sex steroids in patients with osteoporotic spinal fractures.

1983 • 82 citations

Characteristics of steroid hormone receptors in cultured MC3T3-E1 osteoblastic cells and effect of steroid hormones on cell proliferation

1992 • 82 citations

Effects of androgens on parathyroid hormone and interleukin-1-stimulated prostaglandin production in cultured neonatal mouse calvariae

1990 • 82 citations

Flutamide-mediated androgen blockade evokes osteopenia in the female rat

1993 • 81 citations

The effect of orchidectomy on bone metabolism in aging rats

1986 • 79 citations

Changes in plasma steroids and bone density in Klinefelter's syndrome

1976 • 76 citations

Risk factors for hip fractures in men: A preliminary study

1991 • 75 citations

The Metabolism of 7α-³H-Testosterone by Rat Mandibular Bone¹

1974 • 73 citations

The aged male rat as a model for human osteoporosis: Evaluation by nondestructive measurements and biomechanical testing

1993 • 70 citations

Estrogen modulation of avian osteoclast lysosomal gene expression.

1993 • 70 citations

Relationship between antigen-induced immune stimulation and activation of the hypothalamic-pituitary-adrenal axis in the rat.

1993 • 65 citations

Bone changes after castration in rats. A model for osteoporosis

1986 • 64 citations

Effect of sex steroids on bone collagen synthesis in vitro

1978 • 62 citations

Autocrine regulators of MC3T3-E1 cell proliferation

1993 • 57 citations

Interaction of androgen and 1,25-dihydroxyvitamin D3: Effects on normal rat bone cells

1992 • 57 citations

ADRENAL STEROIDS AND THE DEVELOPMENT OF OSTEOPOROSIS IN OOPHORECTOMISED WOMEN

1979 • 52 citations

Growth and bone haemodynamic responses to castration in male rats. Reversibility by testosterone

1984 • 49 citations

Effects of sex steroids on the development of sexual dimorphism in mouse innominate bone

1992 • 48 citations

Lower Calcitonin Levels in Young Hypogonadic Men with Osteoporosis

1983 • 47 citations

Androgen resistance and deficiency have different effects on the growing skeleton of the rat

1994 • 47 citations

Differences in axial bone mineral density, serum levels of sex steroids, and bone metabolism between postmenopausal and age- and body size-matched premenopausal subjects

1993 • 43 citations

Effect of testosterone on bone in hypogonadal males

1992 • 41 citations

Sex-specific response of bone cells to gonadal steroids: modulation in perinatally androgenized females and in testicular feminized male rats

1993 • 39 citations

The effect of sex hormones on bone resorption by rat osteoclasts

1991 • 38 citations

Excess androgenicity only partially explains the relationship between obesity and bone density in premenopausal women.

1992 • 33 citations

Forearm mineral content in normal men: Relationship to weight, height and plasma testosterone concentrations

1988 • 33 citations

Failure of isolated rat tibial periosteal cells to 5α reduce testosterone to 5α-dihydrotestosterone

1990 • 30 citations

Estrogens and bone

1990 • 26 citations

Endogenous oestrogen and bone loss following oophorectomy

1976 • 25 citations

A comparison of microanatomic basis for coupling between bone formation and bone resorption in man and the rat

1993 • 17 citations

Effects of Calcium Deprivation and Orchidectomy on Bone Composition in the Rat

1979 • 14 citations

Reduced Calcitonin Reserve in Young Hypogonadic Osteoporotic Men

1987 • 14 citations

A Scanning Electron-Microscopic Study of Femoral Bone Surfaces from Castrate Rats Treated with Dichloromethylene Biphosphonate

1986 • 12 citations