The hamster adrenal cytochrome P450C11 has equipotent 11β-hydroxylase and 19-hydroxylase activities, but no aldosterone synthase activity

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

[18] Hybridization of denatured RNA transferred or dotted to nitrocellulose paper

1983 • 1,112 citations

New procedure for DNA transfection with polycation and dimethyl sulfoxide.

1984 • 481 citations

Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).

1989 • 440 citations

Characterization of Two Genes Encoding Human Steroid 11β-Hydroxylase (P-45011β)

1989 • 377 citations

The Product of the CYP11B2 Gene Is Required for Aldosterone Biosynthesis in the Human Adrenal Cortex

1991 • 348 citations

Cloning of cDNA encoding steroid 11 beta-hydroxylase (P450c11).

1987 • 211 citations

Human kidney 11 beta-hydroxysteroid dehydrogenase is a high affinity nicotinamide adenine dinucleotide-dependent enzyme and differs from the cloned type I isoform.

1994 • 176 citations

Different Isozymes of Mouse 11/ß-Hydroxylase Produce Mineralocorticoids and Glucocorticoids

1991 • 172 citations

The synthesis of aldosterone by the adrenal cortex. Two zones (fasciculata and glomerulosa) possess one enzyme for 11 beta-, 18-hydroxylation, and aldehyde synthesis.

1986 • 168 citations

Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism

1990 • 155 citations

Cloning of cDNA and genomic DNA for human cytochrome P‐450_11β

1990 • 98 citations

Molecular cloning and expression of cDNAs encoding rat aldosterone synthase : variants of cytochrome P-450[11β]

1992 • 95 citations

Molecular cloning and sequence analysis of cDNA encoding rat adrenal cytochrome P‐450_11β

1989 • 87 citations

19-Nor-Deoxycorticosterone: A Potent Mineralcocorticoid Isolated from the Urine of Rats with Regenerating Adrenals*

1979 • 82 citations

Dietary potassium supplementation and sodium restriction stimulate aldosterone synthase but not 11 beta-hydroxylase P-450 messenger ribonucleic acid accumulation in rat adrenals and require angiotensin II production.

1992 • 82 citations

Universal promoter for gene expression without cloning: expression-PCR.

1991 • 68 citations

Isolation and characterization of rat CYP11B genes involved in late steps of mineralo- and glucocorticoid syntheses.

1993 • 66 citations

Enzymatic Activities of P-450(llβ)s Expressed by Two cDNAs in COS-7 Cells1

1990 • 64 citations

Human kidney 11 beta-hydroxysteroid dehydrogenase is a high affinity nicotinamide adenine dinucleotide-dependent enzyme and differs from the cloned type I isoform

1994 • 61 citations

Expression of Two Kinds of Cytochrome P-450(11β) mRNA in Bovine Adrenal Cortex

1988 • 60 citations

Identification of 19-Hydroxydeoxycorticosterone, 19-Oxo-Deoxycorticosterone, and 19-Oic-Deoxycorticosterone as Products of Deoxycorticosterone Metabolism by Rat Adrenals*

1982 • 59 citations

19-NOR DEOXYCORTKOSTERONE (19-nor DOC): MINERALOCORTICOID RECEPTOR AFFINITY HIGHER THAN ALDOSTERONE, ELECTROLYTE ACTIVITY LOWER.+

1978 • 51 citations

Functional expression of the cDNAs encoding rat 11β‐hydroxylase [cytochrome P450(11β)] and aldosterone synthase [cytochrome P450(11β, aldo)]

1991 • 44 citations

In vivo effects of adrenocorticotropin on hamster adrenal steroidogenic enzymes.

1992 • 42 citations

Urinary 19-Nor-Deoxycorticosterone Excretion in the Spontaneously Hypertensive Rat*

1982 • 42 citations

19-Nor-deoxycorticosterone in the neutral fraction of human urine

1981 • 41 citations

Regulation of rat adrenal messenger RNA and protein levels for cytochrome P-450s and adrenodoxin by dietary sodium depletion or potassium intake

1991 • 39 citations

Structural Analysis of Multiple Bovine P-450(11β) Genes and Their Promoter Activities1

1990 • 37 citations

19-Nor-Deoxycorticosterone Excretion in Primary Aldosteronism and Low Renin Hypertension*

1983 • 36 citations

Identification of 19-hydroxydeoxycorticosterone in regenerating rat adrenal incubations

1980 • 35 citations

Plasma and Urinary 19-Nor-Deoxycorticosterone in 17α-Hydroxylase Deficiency Syndrome*

1984 • 34 citations

Dietary potassium supplementation and sodium restriction stimulate aldosterone synthase but not 11 beta-hydroxylase P-450 messenger ribonucleic acid accumulation in rat adrenals and require angiotensin II production

1992 • 34 citations

Molecular biology of rat steroid 11ß-hydroxylase [P450(11ß)] and aldosterone synthase [P450(11ß, Aldo)]

1992 • 26 citations

Production of 19-hydroxy-11-deoxycorticosterone and 19-oxo-11-deoxycorticosterone from 11-deoxycorticosterone by cytochrome P-45011β

1987 • 25 citations

HYDROXYLATION OF 11-DEOXYCORTICOSTERONE BY ADRENALS OF VARIOUS ANIMAL SPECIES

1963 • 23 citations

Production of 19-oic-11-deoxycorticosterone from 19-oxo-11-deoxycorticosterone by cytochrome P-450,11β and nonenzymatic production of 19-nor-11-deoxycorticosterone from 19-oic-11-deoxycorticosterone

1988 • 23 citations

Transcriptional activation of adrenocortical steroidogenic genes by high potassium or low sodium intake

1993 • 23 citations

Elevated Urinary 19-Nor-Deoxycorticosterone Glucuronide in Cushing’s Syndrome*

1987 • 22 citations

Cloning and expression of cytochrome P450(11β) of porcine adrenal cortex

1995 • 22 citations

The presence of two cytochrome P450 aldosterone synthase mRNAs in the hamster adrenal

1994 • 21 citations

Mineralocorticoid activity of 19-nor-DOC and 19-OH-DOC in toad bladder

1981 • 21 citations

Evidence Supporting the Renal Synthesis of 19-NOR-Deoxycorticosterone

1984 • 18 citations

In vivo regulation of gene expression of enzymes controlling aldosterone synthesis in rat adrenal

1992 • 18 citations

Influence of captopril on adrenal cytochrome P-450s and adrenodoxin expression in high potassium or low sodium intake

1992 • 18 citations

19-Nor-Deoxycorticosterone Excretion in Rats Bred for Susceptibility and Resistance to the Hypertensive Effects of Salt*

1985 • 17 citations

Gerbil adrenal 11β- and 19-hydroxylating activities respond similarly to inhibitory or stimulatory agents: Two activities of a single enzyme

1988 • 12 citations

Effect of ACTH suppression on adrenal 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA in 4-aminopyrazolopyrimidine-treated rats

1990 • 11 citations

19-Nor-Corticosteroids in Health, in Hypertensive States in Humans Including 170-Hydroxylase Defficiency and in the Spontaneously Hypertensive Rat (SHR)

1984 • 9 citations

19-Nor-deoxycorticosterone production from aldosterone-producing adenomas.

1992 • 8 citations

The differential regulation of aldosterone output in hamster adrenal by angiotensinII and adrenocorticotropin

1992 • 6 citations

Unconjugated and conjugated urinary 19-nor-deoxycorticosterone glucosiduronate. Elevated levels in essential hypertension.

1985 • 6 citations

Biphasic 19-Nor-Deoxycorticosterone Excretion after Adrenal Enucleation Is Associated with Altered Adrenal Mitochondrial Cytochrome P450 11β-, 18-, and 19-Hydroxylase Activities*

1987 • 5 citations

Metabolism of 11-deoxycorticosterone by hamster adrenal mitochondria

1992 • 2 citations