Ionic regulation of egg activation

The Cell in Development and Heredity

1925 • 1,750 citations

Stimulus‐secretion coupling: the concept and clues from chromaffin and other cells

1968 • 1,393 citations

T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes

1982 • 1,026 citations

The Cell in Development and Heredity

1925 • 767 citations

Inward current channels activated by intracellular Ca in cultured cardiac cells

1981 • 687 citations

Calcium transport in contraction and secretion

1975 • 567 citations

Intracellular pH and activation of sea urchin eggs after fertilisation

1976 • 561 citations

A free calcium wave traverses the activating egg of the medaka, Oryzias latipes.

1978 • 546 citations

Intracellular calcium release at fertilization in the sea urchin egg

1977 • 523 citations

Fast block to polyspermy in sea urchin eggs is electrically mediated

1976 • 456 citations

Activation of Sea-Urchin Eggs by a Calcium Ionophore

1974 • 454 citations

An Outline of General Physiology.

1944 • 452 citations

Membrane fusion

1973 • 434 citations

Isolation of bindin: the protein responsible for adhesion of sperm to sea urchin eggs.

1977 • 430 citations

The Regulation of Intracellular Calcium

1978 • 415 citations

Is calcium ionophore a universal activator for unfertilised eggs?

1974 • 388 citations

Increased sodium ion influx is necessary to initiate rat hepatocyte proliferation

1979 • 376 citations

Free calcium increases explosively in activating medaka eggs.

1977 • 367 citations

The isolation of intact cortical granules from sea urchin eggs: Calcium ions trigger granule discharge

1975 • 350 citations

Stimulation of Ca ²⁺ -dependent neurotransmitter release and presynaptic nerve terminal protein phosphorylation by calmodulin and a calmodulin-like protein isolated from synaptic vesicles

1979 • 346 citations

pH-dependent fusion between the Semliki Forest virus membrane and liposomes.

1980 • 344 citations

Free Ca2+ increases in exponential phases during mouse oocyte activation

1981 • 322 citations

Serum stimulates the Na+,K+ pump in quiescent fibroblasts by increasing Na+ entry.

1978 • 319 citations

Calcium and the Secretory Process

1974 • 318 citations

Release of ovoperoxidase from sea urchin eggs hardens the fertilization membrane with tyrosine crosslinks

1977 • 313 citations

Direct measurement of intracellular pH during metabolic derepression of the sea urchin egg

1978 • 300 citations

Developmental Biology of the Sea Urchin Embryo

1973 • 285 citations

Chapter 7 Mechanisms of Activation of Sperm and Egg During Fertilization of Sea Urchin Gametes

1978 • 282 citations

Effects of actinomycin D on macromolecule synthesis and early development in sea urchin eggs

1963 • 280 citations

Electrical Properties of Egg Cell Membranes

1979 • 277 citations

Chemical characterization of the component of the jelly coat from sea urchin eggs responsible for induction of the acrosome reaction

1979 • 275 citations

Rapid ionic events and the initiation of growth in serum-stimulated neuroblastoma cells

1981 • 242 citations

Intracellular pH controls protein synthesis rate in the sea urchin egg and early embryo

1979 • 219 citations

Chemistry and Physiology of Fertilization

1965 • 217 citations

Biosynthetic pathways of two polypeptide subunits of the light-harvesting chlorophyll a/b protein complex.

1981 • 211 citations

The DNA synthetic period during early development of the sea urchin egg

1964 • 209 citations

Secretory functions of egg cortical granules in fertilization and development: A critical review

1978 • 209 citations

THE ROLES OF CALCIUM AND CYCLIC AMP IN CELL PROLIFERATION

1980 • 205 citations

The American Arbacia and other sea urchins

1956 • 205 citations

pH regulates the polymerization of actin in the sea urchin egg cortex.

1979 • 201 citations

The molecular basis of immune cell function

1980 • 201 citations

Bioelectric Responses of the Echinoderm Egg to Fertilization

1971 • 199 citations

Membrane fusion during secretion: cortical granule exocytosis in sex urchin eggs as studied by quick-freezing and freeze-fracture.

1979 • 196 citations

Protein synthesis in sea urchin eggs: a "late" response to fertilization.

1967 • 191 citations

Dynamic changes of the egg cortex

1981 • 189 citations

The release of calcium in Arbacia eggs on fertilization

1937 • 185 citations

CALCIUM EXPLOSIONS AS TRIGGERS OF DEVELOPMENT

1980 • 182 citations

Über die Oxydationen in lebenden Zellen nach Versuchen am Seeigelei

1910 • 181 citations

An analysis of the partial metabolic derepression of sea urchin eggs by ammonia: The existence of independent pathways

1974 • 181 citations

Changes in the topography of the sea urchin egg after fertilization.

1976 • 180 citations

Detection and Measurement of Free Ca2+ in Cells

1980 • 178 citations

Calmodulin activates NAD kinase of sea urchin eggs: An early event of fertilization

1981 • 174 citations

Activation of protein biosynthesis in non-nucleate fragments of sea urchin eggs

1964 • 173 citations

Actin, microvilli, and the fertilization cone of sea urchin eggs.

1980 • 170 citations

Protease released from sea urchin eggs at fertilization alters the vitelline layer and aids in preventing polyspermy

1973 • 163 citations

The activation of sea urchin eggs by the divalent ionophores A23187 and X-537A

1974 • 163 citations

The calmodulin hypothesis of neurotransmission

1981 • 161 citations

Membrane potential, action potential and activation potential of eggs of the sea urchin, Lytechinus variegatus

1979 • 161 citations

Measurements of messenger RNA entering polysomes upon fertilization of sea urchin eggs

1971 • 159 citations

Carbohydrate specificity of sea urchin sperm bindin: a cell surface lectin mediating sperm-egg adhesion.

1982 • 157 citations

Calmodulin confers calcium sensitivity on secretory exocytosis

1982 • 155 citations

Artificial Parthenogenesis and Fertilization.

1917 • 154 citations

Egg surface glycoprotein receptor for sea urchin sperm bindin.

1978 • 146 citations

The role of calcium ions in the acrosome reaction of sea urchin sperm

1977 • 145 citations

Dual ionic controls for the activation of protein synthesis at fertilization

1980 • 143 citations

Free calcium ions in neurones of Helix aspersa measured with ion‐selective micro‐electrodes.

1981 • 142 citations

Calcium Binding, Quantum Yield, and Emitting Molecule in Aequorin Bioluminescence

1970 • 140 citations

Species specific agglutination of eggs by bindin isolated from sea urchin sperm

1977 • 139 citations

Methods for quantitating sea urchin sperm-egg binding

1973 • 133 citations

The Cell Surface

1975 • 132 citations

Structural organization of actin in the sea urchin egg cortex: microvillar elongation in the absence of actin filament bundle formation

1982 • 131 citations

Influence of ATP and calcium on the cortical reaction in sea urchin eggs

1978 • 130 citations

A test for masked message: The template activity of messenger ribonucleoprotein particles isolated from sea urchin eggs

1978 • 130 citations

Direct measurement of intracellular pH changes in Xenopus eggs at fertilization and cleavage.

1981 • 130 citations

Identification of a sperm receptor on the surface of the eggs of the sea urchin Arbacia punctulata.

1977 • 130 citations

Activation of an Na+-dependent amino acid transport system upon fertilization of sea urchin eggs

1972 • 125 citations

Electrically mediated fast polyspermy block in eggs of the marine worm, Urechis caupo.

1979 • 125 citations

Protein phosphorylation

1979 • 124 citations

The Fertilization Reaction in the Sea-Urchin

1951 • 124 citations

Intracellular pH of sea urchin eggs measured by the dimethyloxazolidinedione (DMO) method.

1981 • 124 citations

Prevention of the cortical reaction in fertilized sea urchin eggs by injection of calcium-chelating ligands

1978 • 122 citations

Studies of fertilization. VI. The mechanism of fertilization in arbacia

1914 • 119 citations

Membranes in Growth and Development

1984 • 119 citations

Jelly coat and induction of the acrosome reaction in echinoid sperm

1981 • 117 citations

Hydrogen peroxide production, chemiluminescence, and the respiratory burst of fertilization: Interrelated events in early sea urchin development

1978 • 115 citations

Studies on a cortical layer response to stimulating agents in the Arbacia egg. I. Response to insemination

1939 • 115 citations

Molecular Approaches to The Study of Fertilization

1981 • 113 citations

The Mechanical Properties of the Cell Surface

1955 • 111 citations

Mechanisms of cell change

1980 • 108 citations

Chromosome Cycles Turned on in Unfertilized Sea Urchin Eggs Exposed to NH ₄ OH

1974 • 108 citations

Intracellular pH and the sodium requirement at fertilisation

1979 • 107 citations

The Fertilization Reaction in the Sea-Urchin Egg

1949 • 106 citations

Activation of sea urchin eggs by microinjection of calcium buffers

1981 • 106 citations

Measurements of the pH within dormant and germinated bacterial spores.

1980 • 104 citations

Membrane noise and conductance increase during single spermatozoon—egg interactions

1978 • 104 citations

pH changes associated with meiotic maturation in oocytes of Xenopus laevis

1981 • 103 citations

Compartmentation in relation to metabolic control in liver.

1971 • 102 citations

Species-specificity of acrosome reaction and primary gamete binding in echinoids

1975 • 101 citations

A primary metabolic change of fertilization: Interconversion of pyridine nucleotides

1964 • 100 citations

Intracellular calcium release and the mechanisms of parthenogenetic activation of the sea urchin egg

1978 • 99 citations

Development of K+-Conductance and Membrane Potentials in Unfertilized Sea Urchin Eggs after Exposure to NH4OH

1973 • 98 citations

Properties of Fertilizin and Related Substances of Eggs and Sperm of Marine Animals

1949 • 97 citations

Beitrage zur Kenntniss der Bildung, Befruchtung und Theilung des thierischen Eies

1890 • 96 citations

PERIODIC CHANGE IN THE TENSION AT THE SURFACE OF ACTIVATED NON‐NUCLEATE FRAGMENTS OF SEA‐URCHIN EGGS

1978 • 96 citations

DNA synthesis turned on in unfertilized sea urchin eggs by treatment with NH4OH

1974 • 95 citations

Fertilization of sea urchin eggs is accompanied by 40 S ribosomal subunit phosphorylation

1981 • 94 citations

Effects of cytochalasin B on sperm-egg interactions

1978 • 94 citations

Sequential biochemical and morphological events during assembly of the fertilization membrane of the sea urchin

1977 • 93 citations

Efficiency of translation of messenger-RNA before and after fertilization in sea urchins

1969 • 92 citations

Mechanisms of Fertilization in Fishes

1981 • 92 citations

Chapter 2 Immunoperoxidase Localization of Bindin During the Adhesion of Sperm to Sea Urchin Eggs

1979 • 89 citations

The time course of cortical vesicle fusion in sea urchin eggs observed as membrane capacitance changes

1978 • 89 citations

Mechanism of action of NH4Cl and other weak bases in the activation of sea urchin eggs

1978 • 88 citations

How is polyspermy prevented?

1981 • 87 citations

Membrane potential of the unfertilized sea urchin egg

1978 • 84 citations

Measurement of changes in cytoplasmic free Ca2+ in fused cell hybrids

1982 • 83 citations

THE ROLE OF EXTERNAL SODIUM IN SEA URCHIN FERTILIZATION11This work was supported by a grant from the National Science Foundation to Dr. D. Epel.

1978 • 81 citations

The Fertilization Reaction in the Sea-Urchin

1952 • 78 citations

Activation of protein synthesis in a sea urchin cell-free system

1981 • 78 citations

Incorporation of N15-labeled glycine and alanine into the proteins of developing sea urchin eggs

1952 • 75 citations

The Movement of the Egg Nucleus in Relation to the Sperm Aster in the Echinoderm Egg

1939 • 74 citations

RE-FERTILIZATION OF THE FERTILIZED EGGS OF THE SEA URCHIN

1951 • 74 citations

RELATION BETWEEN THE ACROSOME REACTION AND FERTILIZATION IN THE SEA URCHIN. I. FERTILIZATION IN Ca-FREE SEA WATER WITH EGG-WATER-TREATED SPERMATOZOA. *

1973 • 71 citations

Proliferation of human peripheral blood lymphocytes induced by A23187, a streptomyces antibiotic

1976 • 69 citations

Intracellular pH controls the development of new potassium conductance after fertilization of the sea urchin egg

1980 • 69 citations

Efficiency of protein synthesis after fertilisation of sea urchin eggs

1979 • 68 citations

Fertilization and activation of sea urchin eggs in glass capillaries I. Membrane elevation and nuclear movements in totally and partially fertilized eggs

1954 • 66 citations

Elevation of protein synthesis is a complex response to fertilisation

1979 • 66 citations

IONIC EVENTS AT THE MEMBRANE INITIATE RAT LIVER REGENERATION*

1980 • 66 citations

A calcium hypothesis for the control of cell growth.

1980 • 65 citations

The relation between the increase in reduced nicotinamide nucleotides and the initiation of DNA synthesis in sea urchin eggs

1981 • 65 citations

Tryptic disruption of sperm-binding site of sea urchin egg surface

1972 • 64 citations

A reevaluation of the fertilizin hypothesis of sperm agglutination and the description of a novel form of sperm adhesion

1976 • 63 citations

Detection and measurement of free Ca2+ in cells

1981 • 62 citations

A CYTOLOGICAL STUDY OF THE RELATION OF THE CORTICAL REACTION TO SUBSEQUENT EVENTS OF FERTILIZATION IN URETHANE-TREATED EGGS OF THE SEA URCHIN, ARBACIA PUNCTULATA

1970 • 62 citations

Control of cell division: a unifying hypothesis.

1975 • 61 citations

Phytohemagglutinin stimulation of guanylate cyclase in human lymphocytes.

1981 • 61 citations

Oxidative pathways for glucose in eggs of the sea urchin

1956 • 60 citations

Na is essential for activation of the inseminated sea urchin egg

1976 • 60 citations

Related effects of calcium and serum on the G1 phase of the human WI38 fibroblast

1980 • 59 citations

The rise and fall of intracellular pH of sea urchin eggs after fertilisation

1977 • 59 citations

The time sequence of early events in the fertilization of sea urchin eggs

1958 • 59 citations

The relation between ionized calcium and cortical granule exocytosis in eggs of the sea urchin Echinus esculentus

1980 • 59 citations

DNA synthesis in unfertilized sea urchin eggs can be turned on and turned off by the addition and removal of procaine hydrochloride

1975 • 58 citations

Intracellular pH: Methods and Applications

1979 • 58 citations

Membrane potential, membrane resistance and an energy requirement for the development of potassium conductance in the fertilization reaction of echinoderm eggs

1972 • 56 citations

The role of divalent cations in activation of the sea urchin egg. I. Effect of fertilization on divalent cation content

1976 • 55 citations

Measurement of the internal pH of yeast spores by 31P nuclear magnetic resonance.

1980 • 54 citations

An electrophysiological study of the membrane properties of the immature and mature oocyte of the Batstar, Patiria miniata

1976 • 54 citations

Physiological studies on the sperm surface component responsible for sperm-egg bonding in sea urchin fertilization

1973 • 52 citations

Maturation and fertilization of the sea urchin oocyte: An electrophysiological study

1981 • 52 citations

Physiological studies on the sperm surface component responsible for sperm-egg bonding in sea urchin fertilization

1975 • 52 citations

Physico-chemical properties of the fertilizins of the sea urchin Arbacia punctulata and the sand dollar Echinarachnius parma

1956 • 50 citations

ASPECTS OF THE FUSION OF CELLS IN VITRO WITHOUT VIRUSES

1975 • 50 citations

Observations on intracellular pH during cleavage of eggs of Xenopus laevis.

1981 • 50 citations

A rapid sodium-dependent block to polyspermy in sea urchin eggs

1981 • 49 citations

Sperm binding and fertilization envelope formation in a cell surface complex isolated from sea urchin eggs.

1979 • 49 citations

Localized gating of egg Na+ channels by sperm

1981 • 48 citations

Mechanism for Increase in Intracellular Concentration of Free Calcium in Fertilized Sea Urchin Egg

1974 • 47 citations

Mechanical properties of the surface of the sea urchin egg at fertilization and during cleavage*1

1974 • 46 citations

On the acid formation, breakdown of cytoplasmic inclusions, and increased viscosity in Paracentrotus egg homogenates after the addition of calcium

1950 • 46 citations

Fertilization-associated light-scattering changes in eggs of the sea urchin

1971 • 46 citations

Pathways of carbohydrate breakdown in sea urchin eggs

1968 • 45 citations

Voltage response to fertilization and polyspermy in sea urchin eggs and oocytes

1979 • 45 citations

ELECTRICAL POLYSPERMY BLOCK IN SEA URCHINS: NICOTINE AND LOW SODIUM EXPERIMENTS1

1980 • 45 citations

Development and life cycle of the parthenogenetically activated sea urchin embryo

1975 • 44 citations

Relationship between release of surface proteins and metabolic activation of sea urchin eggs at fertilization.

1975 • 44 citations

Isolation of a high molecular weight glycoconjugate derived from the surface of S purpuratus eggs that is implicated in sperm adhesion

1981 • 43 citations

On the oxygen uptake of Paracentrotus lividus egg homogenates after the addition of calcium

1950 • 43 citations

Uptake OF Ca²⁺ is one of the earliest responses to fertilization of sea urchin eggs

1978 • 42 citations

The "late" Ca channel in squid axons.

1981 • 41 citations

Binding of concanavalin A to the surface of sea urchin eggs and its alteration upon fertilization.

1977 • 40 citations

FLAGELLAR MOTILITY IS NOT INVOLVED IN THE INCORPORATION OF THE SPERM INTO THE EGG AT FERTILIZATION*

1977 • 40 citations

Cytochalasin B blocks sperm incorporation but allows activation of the sea urchin egg

1980 • 39 citations

Absence of fast block to polyspermy in eggs of sea urchin Strongylocentrotus purpuratus

1975 • 39 citations

Antibody to a sperm surface glycoprotein inhibits the egg jelly-induced acrosome reaction of sea urchin sperm

1980 • 39 citations

Chapter 5 Sperm and Egg Receptors Involved in Fertilization

1978 • 38 citations

Alteration of sodium transport in mouse mammary epithelium associated with neoplastic transformation.

1978 • 38 citations

Hexose monophosphate level as a limiting factor for respiration in unfertilized sea-urchin eggs

1964 • 37 citations

Sea urchin egg and embryo ribosomes: Differences in translational activity in a cell-free system

1981 • 37 citations

A hydrogen peroxide block to polyspermy in the sea urchin Arbacia punctulata

1981 • 37 citations

Simultaneous measurement of TPNH formation and respiration following fertilization of the sea urchin egg

1964 • 36 citations

Non-propagated cortical reactions induced by the divalent ionophore A23187 in eggs of the sea urchin, Lytechinus variegatus

1979 • 36 citations

An outline of general physiology

1938 • 34 citations

When do sperm of the sea urchin, Pseudocentrotus depressus, undergo the acrosome reaction at fertilization?

1977 • 34 citations

Inherited disorders in the regulation of serum calcium in rats raised from parathyroidectomised mothers

1978 • 33 citations

Studies on the interactions of sperm with the surface of the sea urchin egg

1981 • 33 citations

Effect on fertilization of antiserum against sperm-binding protein from homo- and heterologous sea urchin egg surfaces

1969 • 32 citations

Changes in levels of triphosphopyridine nucleotide in marine eggs subsequent to fertilization

1960 • 32 citations

Kinetics of Fertilization in the Sea Urchin: A Comparison of Methods

1970 • 32 citations

Calcium-induced decrease in membrane fluidity of sea urchin egg cortex after fertilization

1980 • 32 citations

A novel procedure for obtaining denuded sea urchin eggs and observations on the role of the vitelline layer in sperm reception and egg activation

1977 • 32 citations

The Fertilization Reaction in the Sea-Urchin Egg. The Effect of Nicotine

1950 • 31 citations

The effect of trypsin on the cross fertilizability of sea urchin eggs

1953 • 28 citations

Acid and base production at fertilization in the sea urchin

1961 • 27 citations

ACTIVATION OF LYMPHOCYTES OF MAN AND MOUSE: MONOVALENT CATION FLUXES*

1980 • 27 citations

The action of trypsin and chymotrypsin on the sea urchin egg

1954 • 27 citations

Fertilization acid production in Psammechinus eggs under pH clamp conditions, and the effects of some pyrazine derivatives*1

1978 • 25 citations

Mechanisms of cell change

1979 • 24 citations

INTERACTIONS BETWEEN ARBACIA SPERM AND S³⁵—LABELLED FERTILIZIN

1961 • 24 citations

The Cortical Changes on Fertilization of the Sea-Urchin Egg

1955 • 22 citations

Aster formation in sand dollar eggs by micro-injection of calcium buffers and centriolar complexes isolated from starfish sperm

1982 • 21 citations

Effects of inhibitors of protein synthesis on structure and function of the crypts of the small intestine*

1971 • 20 citations

Gaining access to the site of exocytosis in bovine adrenal medullary cells.

1980 • 19 citations

Kinetic Evidence for an Intermediate Stage in the Fertilization of the Sea Urchin Egg

1969 • 16 citations

Reevaluation of cell surface protein release at fertilization and its role in regulation of sea urchin egg protein synthesis

1981 • 14 citations

Early electrical responses to fertilization in sea urchin eggs

1979 • 14 citations

Some Stochastic Models to Describe the Fertilization of an Egg

1975 • 12 citations

CHANGE IN THE GLYCOGEN CONTENT OF SEA URCHIN EGGS DURING EARLY DEVELOPMENT

1979 • 10 citations

Plasma membrane-mediated effects of extracellular pH on the growth of neuroblastoma cells

1981 • 10 citations

Calcium requirements for mitogenic stimulation of 3T3-cells in low and high serum concentration

1981 • 8 citations

Membrane protein detachment and mitogenic stimulation induced by alkaline pH

1981 • 8 citations

Promotion of polyspermy in the sea-urchin egg by nicotine and its antagonism by curare.

1971 • 6 citations

Two pathways from glycogen to glucose‐6‐phosphate in sea urchin eggs with special reference to the difference between the species in the contribution ratio of each pathway

1978 • 6 citations

Electrophoresis of sperm-absorbed univalent sea urchin fertilizin

1967 • 6 citations

Calcium activation of the cortical raction in sea urchin eggs (reply)

1979 • 6 citations

THE BLOCK TO POLYSPERMY IN THE SEA URCHIN

1978 • 5 citations

Intracellular pH during mitogenic stimulation induced by alkaline pH

1981 • 3 citations

Deleted Work

1955 • 0 citations