Differential and Cooperative Polysialylation of the Neural Cell Adhesion Molecule by Two Polysialyltransferases, PST and STX

INHIBITORS OF THE BIOSYNTHESIS AND PROCESSING OF N-LINKED OLIGOSACCHARIDE CHAINS

1987 • 1,122 citations

Site-directed mutagenesis of virtually any plasmid by eliminating a unique site

1992 • 1,089 citations

Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning

1994 • 1,010 citations

Kinetics of homophilic binding by embryonic and adult forms of the neural cell adhesion molecule.

1983 • 635 citations

PSA–NCAM Is Required for Activity-Induced Synaptic Plasticity

1996 • 582 citations

Characterization of the structural determinants required for the high affinity interaction of asparagine-linked oligosaccharides with immobilized Phaseolus vulgaris leukoagglutinating and erythroagglutinating lectins.

1982 • 536 citations

Polysialic acid in the vertebrate nervous system: a promoter of plasticity in cell-cell interactions

1996 • 519 citations

Carbohydrate structure of erythropoietin expressed in Chinese hamster ovary cells by a human erythropoietin cDNA.

1987 • 485 citations

Genetic deletion of a neural cell adhesion molecule variant (N-CAM-180) produces distinct defects in the central nervous system

1993 • 476 citations

Primary structure of beta-galactoside alpha 2,6-sialyltransferase. Conversion of membrane-bound enzyme to soluble forms by cleavage of the NH2-terminal signal anchor.

1987 • 408 citations

CELL ADHESION AND THE MOLECULAR PROCESSES OF MORPHOGENESIS

1985 • 400 citations

The Role of Polysialic Acid in Migration of Olfactory Bulb Interneuron Precursors in the Subventricular Zone

1996 • 357 citations

Adult and embryonic mouse neural cell adhesion molecules have different binding properties

1983 • 350 citations

Occurrence of unique polysialosyl carbohydrate units in glycoproteins of developing brain.

1982 • 324 citations

Polysialic acid in the vertebrate nervous system: a promoter of plasticity in cell-cell interactions

1996 • 319 citations

The neural cell adhesion molecule N-CAM enhances L1-dependent cell-cell interactions.

1990 • 305 citations

Molecular characterization of eukaryotic polysialyltransferase-1

1995 • 286 citations

Accumulation of membrane glycoproteins in lysosomes requires a tyrosine residue at a particular position in the cytoplasmic tail.

1990 • 272 citations

Translocation across golgi vesicle membranes: A CHO glycosylation mutant deficient in CMP-sialic acid transport

1984 • 266 citations

Expression cloning of a human polysialyltransferase that forms the polysialylated neural cell adhesion molecule present in embryonic brain.

1995 • 237 citations

Cell biology of polysialic acid

1997 • 227 citations

Human muscle neural cell adhesion molecule (N-CAM): Identification of a muscle-specific sequence in the extracellular domain

1987 • 221 citations

Primary structure of Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase determined by mass spectrometry sequence analysis and molecular cloning. Evidence for a protein motif in the sialyltransferase gene family.

1992 • 191 citations

The Sialyltransferase “Sialylmotif” Participates in Binding the Donor Substrate CMP-NeuAc

1995 • 190 citations

Polymerase chain reaction cloning of a developmentally regulated member of the sialyltransferase gene family

1993 • 180 citations

Extended polysialic acid chains (n greater than 55) in glycoproteins from human neuroblastoma cells.

1988 • 151 citations

A Human STX cDNA Confers Polysialic Acid Expression in Mammalian Cells

1995 • 149 citations

Identification of a peptide sequence involved in homophilic binding in the neural cell adhesion molecule NCAM.

1992 • 145 citations

Expression cloning of a GM3-specific alpha-2,8-sialyltransferase (GD3 synthase).

1994 • 145 citations

Human STX Polysialyltransferase Forms the Embryonic Form of the Neural Cell Adhesion Molecule

1997 • 137 citations

Developmental regulation of polysialic acid synthesis in mouse directed by two polysialyltransferases, PST and STX

1998 • 136 citations

Protein Determinants for Specific Polysialylation of the Neural Cell Adhesion Molecule

1995 • 128 citations

Transfer and expression of a murine UDP-Gal:beta-D-Gal-alpha 1,3-galactosyltransferase gene in transfected Chinese hamster ovary cells. Competition reactions between the alpha 1,3-galactosyltransferase and the endogenous alpha 2,3-sialyltransferase.

1990 • 125 citations

Homophilic adhesion mediated by the neural cell adhesion molecule involves multiple immunoglobulin domains.

1996 • 122 citations

Characterization of Mouse ST8Sia II (STX) as a Neural Cell Adhesion Molecule-specific Polysialic Acid Synthase

1996 • 121 citations

Granulocytic differentiation of HL-60 cells is associated with increase of poly-N-acetyllactosamine in Asn-linked oligosaccharides attached to human lysosomal membrane glycoproteins

1990 • 120 citations

Enzymatic activity of a developmentally regulated member of the sialyltransferase family (STX): evidence for α2,8‐sialyltransferase activity toward N‐linked oligosaccharides

1995 • 101 citations

Characterization of the Antigenic Specificity of Four Different Anti-(α2→8-Linked Polysialic Acid) Antibodies Using Lipid-conjugated Oligo/Polysialic Acids

1995 • 93 citations

Branched O-linked oligosaccharides ectopically expressed in transgenic mice reduce primary T-cell immune responses

1997 • 92 citations

Molecular Cloning and Expression of GDP-d-mannose-4,6-dehydratase, a Key Enzyme for Fucose Metabolism Defective in Lec13 Cells

1998 • 91 citations

Molecular Cloning and Characterization of a Third Type of N-Glycan α2, 8-Sialyltransferase from Mouse Lung1

1995 • 81 citations

Two chinese hamster ovary glycosylation mutants affected in the conversion of GDP-mannose to GDP-fucose

1986 • 79 citations

A Human Polysialyltransferase Directs in Vitro Synthesis of Polysialic Acid

1996 • 75 citations

Polysialylation of NCAM by a single enzyme

1996 • 74 citations

Regulation of Neural Cell Adhesion Molecule Polysialylation: Evidence for Nontranscriptional Control and Sensitivity to an Intracellular Pool of Calcium

1998 • 70 citations

Polysialic Acid Synthase (ST8Sia II/STX) mRNA Expression in the Developing Mouse Central Nervous System

1997 • 63 citations

Characterization of the Major Core Structures of the α2→8-linked Polysialic Acid-containing Glycan Chains Present in Neural Cell Adhesion Molecule in Embryonic Chick Brains

1996 • 61 citations

Developmental expression of two rat sialyltransferases that modify the neural cell adhesion molecule, N-CAM

1997 • 58 citations

A monoclonal antibody (ERIC-1), raised against retinoblastoma, that recognizes the neural cell adhesion molecule (NCAM) expressed on brain and tumours arising from the neuroectoderm

1991 • 55 citations

Developmental expression of trout egg polysialoglycoproteins and the prerequisite alpha 2,6-, and alpha 2,8-sialyl and alpha 2,8-polysialyltransferase activities required for their synthesis during oogenesis.

1994 • 50 citations

Expression of β-galactoside α2,6 sialyltransferase blocks synthesis of polysialic acid in Xenopus embryos

1990 • 44 citations

Cellular Interactions in Development

1993 • 38 citations

1H NMR spectroscopy of carbohydrates from the G glycoprotein of vesicular stomatitis virus grown in parental and Lec4 Chinese hamster ovary cells

1984 • 35 citations

Two Polysialic Acid Syntheses, Mouse ST8Sia II and IV, Synthesize Different Degrees of Polysialic Acids on Different Substrate Glycoproteins in Mouse Neuroblastoma Neuro2a Cells

1997 • 32 citations

Cloning and in situ hybridization analysis of the expression of polysialyltransferase mRNA in the developing and adult rat brain

1997 • 31 citations

Molecular modelling of the immunoglobulin‐like domains of the neural cell adhesion molecule (NCAM): Implications for the positioning of functionally important sugar side chains

1988 • 25 citations