Intrinsic dynamics of an enzyme underlies catalysis

Catalysis in chemistry and enzymology

1969 • 3,236 citations

Relationship between nuclear magnetic resonance chemical shift and protein secondary structure

1991 • 1,888 citations

Dynamics of ligand binding to myoglobin

1975 • 1,616 citations

A Perspective on Enzyme Catalysis

2003 • 1,191 citations

How Enzymes Work: Analysis by Modern Rate Theory and Computer Simulations

2004 • 1,108 citations

NMR Characterization of the Dynamics of Biomacromolecules

2004 • 829 citations

Evolutionarily conserved networks of residues mediate allosteric communication in proteins

2002 • 821 citations

Enzyme Dynamics During Catalysis

2002 • 710 citations

Two-State Allosteric Behavior in a Single-Domain Signaling Protein

2001 • 589 citations

Structure, Dynamics, and Catalytic Function of Dihydrofolate Reductase

2004 • 501 citations

Collective protein dynamics in relation to function

2000 • 411 citations

A general two-site solution for the chemical exchange produced dependence of T2 upon the carr-Purcell pulse separation

1972 • 384 citations

Studying excited states of proteins by NMR spectroscopy.

2001 • 382 citations

Multiple Conformational Changes in Enzyme Catalysis

2002 • 349 citations

Selective Methyl Group Protonation of Perdeuterated Proteins

1996 • 299 citations

[Determination of enzymatic catalysis for the cis-trans-isomerization of peptide binding in proline-containing peptides].

1984 • 299 citations

Flap opening and dimer-interface flexibility in the free and inhibitor-bound HIV protease, and their implications for function

1999 • 264 citations

A TROSY CPMG sequence for characterizing chemical exchange in large proteins.

1999 • 236 citations

Correlated motion and the effect of distal mutations in dihydrofolate reductase

2003 • 208 citations

Reconstructing NMR Spectra of “Invisible” Excited Protein States Using HSQC and HMQC Experiments

2002 • 183 citations

Dynamics of the Flexible Loop of Triose-Phosphate Isomerase: The Loop Motion Is Not Ligand Gated

1995 • 160 citations

Solution-state NMR investigations of triosephosphate isomerase active site loop motion: ligand release in relation to active site loop dynamics11Edited by P. E. Wright

2001 • 157 citations

Defining the role of active-site loop fluctuations in dihydrofolate reductase catalysis

2005 • 156 citations

Evidence for Flexibility in the Function of Ribonuclease A

2002 • 121 citations

Kinetic Analysis of Cyclophilin-Catalyzed Prolyl Cis/Trans Isomerization by Dynamic NMR Spectroscopy

1995 • 121 citations

Protein Dynamics and Enzymatic Catalysis: Investigating the Peptidyl−Prolyl Cis−Trans Isomerization Activity of Cyclophilin A

2004 • 92 citations

Crystal Structure Implies That Cyclophilin Predominantly Catalyzes the Trans to Cis Isomerization^,

1996 • 88 citations

The NMR solution conformation of unligated human cyclophilin A 1 1Edited by P. E. Wright

1997 • 83 citations

Genetic Control of Retrovirus Susceptibility in Mammalian Cells

2004 • 81 citations

Prolyl Isomerases

2001 • 71 citations