A systematic search for protein signature sequences

Basic local alignment search tool

1990 • 87,358 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

Zinc Finger-DNA Recognition: Crystal Structure of a Zif268-DNA Complex at 2.1 Å

1991 • 2,034 citations

The P-loop — a common motif in ATP- and GTP-binding proteins

1990 • 2,029 citations

[5] Rapid and sensitive sequence comparison with FASTP and FASTA

1990 • 1,983 citations

CRYSTAL STRUCTURES OF THE HELIX-LOOP-HELIX CALCIUM-BINDING PROTEINS

1989 • 855 citations

Identification of MRF4: a new member of the muscle regulatory factor gene family.

1989 • 779 citations

Three-dimensional structure of the tryptophan synthase alpha 2 beta 2 multienzyme complex from Salmonella typhimurium.

1988 • 706 citations

An attempt to unify the structure of polymerases

1990 • 640 citations

DNA RECOGNITION BY PROTEINS WITH THE HELIX-TURN-HELIX MOTIF

1990 • 580 citations

A large family of bacterial activator proteins.

1988 • 559 citations

Conserved domains in bacterial regulatory proteins that respond to environmental stimuli

1987 • 537 citations

Protein database searches for multiple alignments.

1990 • 468 citations

The structure of the Antennapedia homeodomain determined by NMR spectroscopy in solution: Comparison with prokaryotic repressors

1989 • 468 citations

A unique signature identifies a family of zinc‐dependent metallopeptidases

1989 • 453 citations

The evolution of α/β barrel enzymes

1990 • 378 citations

Similarity of the three-dimensional structures of actin and the ATPase fragment of a 70-kDa heat shock cognate protein.

1991 • 352 citations

The active-site-serine penicillin-recognizing enzymes as members of the Streptomyces R61 <scp>dd</scp>-peptidase family

1988 • 334 citations

Design of DNA-Binding Peptides Based on the Leucine Zipper Motif

1990 • 296 citations

Automatic generation of primary sequence patterns from sets of related protein sequences.

1990 • 292 citations

Molecular structure of flavocytochrome b2 at 24 Å resolution

1990 • 291 citations

Oligopeptide biases in protein sequences and their use in predicting protein coding regions in nucleotide sequences

1988 • 262 citations

Recent developments in the field of iron‐sulfur proteins

1990 • 223 citations

Sequence and nitrate regulation of the Arabidopsis thaliana mRNA encoding nitrate reductase, a metalloflavoprotein with three functional domains.

1988 • 189 citations

DNA sequence around the Escherichia coli unc operon. Completion of the sequence of a 17 kilobase segment containing asnA, oriC, unc, glmS and phoS

1984 • 159 citations

The structure of crystalline Escherichia coli-derived rat intestinal fatty acid-binding protein at 2.5-A resolution.

1988 • 137 citations

Nucleotide sequence and deduced amino acid sequence of Escherichia coli adenine phosphoribosyl-transferase and comparison with other analogous enzymes

1986 • 136 citations

Multiple sequence alignment

1986 • 128 citations

Flexible protein sequence patterns

1990 • 120 citations

Carotenoid desaturases from Rhodobacter capsulatus and Neurospora crassa are structurally and functionally conserved and contain domains homologous to flavoprotein disulfide oxidoreductases.

1990 • 81 citations

Nucleotide sequence of yeast gene CPA1 encoding the small subunit of arginine‐pathway carbamoyl‐phosphate synthetase

1985 • 70 citations

Conserved Domains in Molybdenum Hydroxylases

1989 • 65 citations

Profile scanning for three-dimensional structural patterns in protein sequences

1988 • 60 citations

Homology of yeast mitochondrial leucyl-tRNA synthetase and isoleucyl- and methionyl-tRNA synthetases of Escherichia coli.

1988 • 44 citations

The elucidation of protein function by sequence motif analysis

1989 • 36 citations

[29] Hierarchical method to align large numbers of biological sequences

1990 • 36 citations

Amino acid sequence templates derived from recurrent turn motifs in proteins: critical evaluation of their predictive power

1989 • 28 citations

Local protein sequence similarity does not imply a structural relationship

1990 • 25 citations

Determination of the active‐site serine of 6‐aminohexanoate‐dimer hydrolase

1989 • 19 citations

Fragment peptide library for classification and functional prediction of proteins

1990 • 12 citations