Multiple sequence alignment

A general method applicable to the search for similarities in the amino acid sequence of two proteins

1970 • 11,049 citations

Similar Amino Acid Sequences: Chance or Common Ancestry?

1981 • 855 citations

Structure of crystalline α-chymotrypsin

1972 • 675 citations

Conformational preferences of amino acids in globular proteins

1978 • 653 citations

The Sequence of Amino Acid Residues in Bovine Pancreatic Ribonuclease: Revisions and Confirmations

1963 • 562 citations

Tests for comparing related amino-acid sequences. Cytochrome c and cytochrome c551

1971 • 440 citations

Homology among DNA-binding proteins suggests use of a conserved super-secondary structure

1982 • 432 citations

An improved method of testing for evolutionary homology

1966 • 313 citations

Molecular cloning and nucleotide sequencing of the gene for E. coli cAMP receptor protein

1982 • 283 citations

Hydrophobic character of amino acid residues in globular proteins

1978 • 282 citations

The Amino Acid Sequence of the γ Chain of Human Fetal Hemoglobin^*

1963 • 275 citations

Glutathione Reductase from Human Erythrocytes

1982 • 238 citations

Nucleotide sequence of cro, cII and part of the O gene in phage λ DNA

1978 • 222 citations

The Structure and History of an Ancient Protein

1972 • 201 citations

Comparison of the three-dimensional protein and nucleotide structure of the FAD-binding domain of p-hydroxybenzoate hydroxylase with the FAD- as well as NADPH-binding domains of glutathione reductase

1983 • 197 citations

Nucleotide sequence encoding the flavoprotein and hydrophobic subunits of the succinate dehydrogenase of Escherichia coli

1984 • 197 citations

Cloning and sequence of the crp gene of Escherichia coli K 12

1982 • 178 citations

Molecular biology, biochemistry and bionergetics of fumarate reductase, a complex membrane-bound iron-sulfur flavoenzyme of Escherichia coli

1985 • 169 citations

Nucleotide Sequence Coding for the Flavoprotein Subunit of the Fumarate Reductase of Escherichia coli

1982 • 168 citations

Frequency of insertion-deletion, transversion, and transition in the evolution of 5S ribosomal RNA

1976 • 138 citations

FAD-binding site of glutathione reductase

1982 • 138 citations

Subtilisin BPN'

1967 • 124 citations

Primary structure of the λ repressor

1978 • 118 citations

Two helix DNA binding motif of CAP found inlacrepressor andgalrepressor

1982 • 110 citations

Amino acid sequence of Cro regulatory protein of bacteriophage lambda

1977 • 104 citations

Proposed α-helical super-secondary structure associated with protein-DNA recognition

1982 • 95 citations

Comparison of the structures of Cro and λ repressor proteins from bacteriophage λ

1983 • 91 citations

Further improvements in the method of testing for evolutionary homology among proteins

1970 • 89 citations

A molecular sequence metric and evolutionary trees

1974 • 85 citations

The Amino Acid Sequence of Ribonuclease T1

1965 • 84 citations

Analysis of gene duplication repeats in the myosin rod

1983 • 70 citations

Sequence homologies amongE. coli ribosomal proteins: Evidence for evolutionarily related groupings and internal duplications

1980 • 69 citations

Primary and Tertiary Structure Studies of p-Hydroxybenzoate Hydroxylase from Pseudomonas fluorescens

2005 • 65 citations

Nucleotide sequence of the cro - cII - oop region of bacteriophage 434 DNA

1979 • 59 citations

The amino acid sequence of ribonuclease T-1.

1965 • 59 citations

An efficient method for matching nucleic acid sequences

1982 • 54 citations

Improvements to a program for DNA analysin: a procedure to find homologies among many sequences

1982 • 45 citations

Primary structure of ribonuclease from bacillus intermedius 7P

1979 • 44 citations

The amino acid sequence of ribonuclease U2 from Ustilago sphaerogena

1975 • 32 citations

The amino acid sequence of ribonuclease St

1976 • 24 citations

Confidence limits for homology in protein or gene sequences

1985 • 24 citations

A statistical test for comparing sveral nucleotide sequences

1982 • 11 citations