A carboxyfullerene SOD mimetic improves cognition and extends the lifespan of mice

The Statistical Analysis of Failure Time Data.

1981 • 10,224 citations

Oxidants, oxidative stress and the biology of ageing

2000 • 8,990 citations

Modeling Survival Data: Extending the Cox Model

2000 • 7,620 citations

The Free Radical Theory of Aging Matures

1998 • 3,846 citations

Oxidative Stress, Caloric Restriction, and Aging

1996 • 3,136 citations

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

2001 • 1,892 citations

The Statistical Analysis of Failure Time Data

1981 • 1,882 citations

Suppression of Aging in Mice by the Hormone Klotho

2005 • 1,777 citations

Extension of Murine Life Span by Overexpression of Catalase Targeted to Mitochondria

2005 • 1,670 citations

Signals from the reproductive system regulate the lifespan of C. elegans

1999 • 956 citations

Extension of Life-Span with Superoxide Dismutase/Catalase Mimetics

2000 • 909 citations

Free radical theory of aging

1992 • 876 citations

Superoxide production in rat hippocampal neurons: selective imaging with hydroethidine

1996 • 868 citations

Calorie Restriction— the SIR2 Connection

2005 • 794 citations

Dietary Restriction in Mice Beginning at 1 Year of Age: Effect on Life-Span and Spontaneous Cancer Incidence

1982 • 757 citations

A learning deficit related to age and β-amyloid plaques in a mouse model of Alzheimer's disease

2000 • 733 citations

Aging and resistance to oxidative damage in Caenorhabditis elegans.

1993 • 720 citations

Pharmacology of Cerebral Ischemia

1989 • 675 citations

Growth Curves and Survival Characteristics of the Animals Used in the Biomarkers of Aging Program

1999 • 658 citations

Fullerenes : chemistry, physics, and technology

2000 • 633 citations

Caloric restriction and aging: an update

2000 • 616 citations

Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence

2005 • 553 citations

Critical evaluation of the use of hydroethidine as a measure of superoxide anion radical

1998 • 489 citations

Sex and Death: What Is the Connection?

2005 • 436 citations

Rapid Isolation of Metabolically Active Mitochondria from Rat Brain and Subregions Using Percoll Density Gradient Centrifugation

1990 • 393 citations

Reversal of age-related learning deficits and brain oxidative stress in mice with superoxide dismutase/catalase mimetics

2003 • 370 citations

A biologically effective fullerene (C60) derivative with superoxide dismutase mimetic properties

2004 • 365 citations

Fullerene-based antioxidants and neurodegenerative disorders

2001 • 333 citations

Effects of intermittent feeding upon body weight and lifespan in inbred mice: interaction of genotype and age

1990 • 266 citations

Impaired Synaptic Plasticity and cAMP Response Element-Binding Protein Activation in Ca²⁺/Calmodulin-Dependent Protein Kinase Type IV/Gr-Deficient Mice

2000 • 251 citations

Genetic mouse models of extended lifespan

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A Role for Superoxide in Protein Kinase C Activation and Induction of Long-term Potentiation

1998 • 194 citations

Effects of food restriction on aging: separation of food intake and adiposity.

1984 • 191 citations

Longevity, Body Weight, and Neoplasia in Ad Libitum-Fed and Diet-Restricted C57BL6 Mice Fed NIH-31 Open Formula Diet

1995 • 188 citations

Aging-Dependent Alterations in Synaptic Plasticity and Memory in Mice That Overexpress Extracellular Superoxide Dismutase

2006 • 178 citations

Cell-Permeable Scavengers of Superoxide Prevent Long-Term Potentiation in Hippocampal Area CA1

1998 • 165 citations

Superoxide dismutase mimetics elevate superoxide dismutase activity in vivo but do not retard aging in the nematode Caenorhabditis elegans

2004 • 161 citations

Treatment with an Amyloid-β Antibody Ameliorates Plaque Load, Learning Deficits, and Hippocampal Long-Term Potentiation in a Mouse Model of Alzheimer's Disease

2005 • 142 citations

Mid-life onset of dietary restriction extends life and prolongs cognitive functioning

1993 • 132 citations

Increased soluble amyloid-β peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein

2004 • 127 citations

No increase in lifespan in Caenorhabditis elegans upon treatment with the superoxide dismutase mimetic EUK-8

2003 • 116 citations

BMCP1: a mitochondrial uncoupling protein in neurons which regulates mitochondrial function and oxidant production

2001 • 111 citations

Dietary intervention at middle age: caloric restriction but not dehydroepiandrosterone sulfate increases lifespan and lifetime cancer incidence in mice.

1999 • 110 citations

Superoxide stress identifies neurons at risk in a model of ataxia‐telangiectasia

2001 • 106 citations

Long-term dietary restriction causes negative effects on cognitive functions in rats

2003 • 102 citations

Paradoxical Actions of Hydrogen Peroxide on Long-Term Potentiation in Transgenic Superoxide Dismutase-1 Mice

2003 • 101 citations

Survival Characteristics and Age-Adjusted Disease Incidences in C57BL/6 Mice Fed a Commonly Used Cereal-Based Diet Modulated by Dietary Restriction

2002 • 98 citations

Multiple Episodes of Mild Traumatic Brain Injury Result in Impaired Cognitive Performance in Mice

2004 • 94 citations

Caloric restriction and spatial learning in old mice

1996 • 65 citations

Multiple Episodes of Mild Traumatic Brain Injury Result in Impaired Cognitive Performance in Mice

2004 • 50 citations

Sample sizes for comparing means of two lifetime distributions with type II censored data:

2003 • 9 citations

Effect of a Guarantee Time on Sample Size Determination for Testing the Ratio of Means from Two Lifetime Distributions

2004 • 2 citations