Toxicological assessment of ambient and traffic-related particulate matter: A review of recent studies

Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage.

2003 • 2,020 citations

Air quality guidelines for Europe

1988 • 1,801 citations

Sources of fine organic aerosol. 2. Noncatalyst and catalyst-equipped automobiles and heavy-duty diesel trucks

1993 • 1,441 citations

Air quality guidelines for Europe.

2000 • 1,287 citations

Tropospheric Air Pollution: Ozone, Airborne Toxics, Polycyclic Aromatic Hydrocarbons, and Particles

1997 • 1,158 citations

Cancer risk from occupational and environmental exposure to polycyclic aromatic hydrocarbons.

1997 • 1,003 citations

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis

2003 • 878 citations

Fine particles and human health—a review of epidemiological studies

2004 • 670 citations

On-Road Emissions of Particulate Polycyclic Aromatic Hydrocarbons and Black Carbon from Gasoline and Diesel Vehicles

1998 • 539 citations

Role of Free Radicals in the Toxicity of Airborne Fine Particulate Matter

2001 • 503 citations

Health effects of particles in ambient air

2004 • 484 citations

Quinoid redox cycling as a mechanism for sustained free radical generation by inhaled airborne particulate matter

2001 • 467 citations

Atmospheric chemistry of gas-phase polycyclic aromatic hydrocarbons: formation of atmospheric mutagens.

1994 • 434 citations

Trace Metal Concentrations and Water Solubility in Size-Fractionated Atmospheric Particles and Influence of Road Traffic

2006 • 372 citations

Sensitive method for the detection of mutagenic nitroarenes and aromatic amines: new derivatives of Salmonella typhimurium tester strains possessing elevated O-acetyltransferase levels

1990 • 326 citations

Subway Particles Are More Genotoxic than Street Particles and Induce Oxidative Stress in Cultured Human Lung Cells

2004 • 309 citations

Insights into the Chemistry of New Particle Formation and Growth Events in Pittsburgh Based on Aerosol Mass Spectrometry

2004 • 297 citations

Free radical activity associated with the surface of particles: a unifying factor in determining biological activity?

1996 • 290 citations

Traffic contribution of polycyclic aromatic hydrocarbons in the center of a large city

1996 • 289 citations

Metal-rich Ambient Particles (Particulate Matter_2.5) Cause Airway Inflammation in Healthy Subjects

2004 • 268 citations

Products and Mechanism of Secondary Organic Aerosol Formation from Reactions ofn-Alkanes with OH Radicals in the Presence of NO_x

2005 • 266 citations

The role of metals in site-specific DNA damage with reference to carcinogenesis1,2 1Guest Editor: Miral Dizdaroglu 2This article is part of a series of reviews on “Oxidative DNA Damage and Repair.” The full list of papers may be found on the homepage of the journal.

2002 • 261 citations

USE OF A STRATIFIED OXIDATIVE STRESS MODEL TO STUDY THE BIOLOGICAL EFFECTS OF AMBIENT CONCENTRATED AND DIESEL EXHAUST PARTICULATE MATTER

2002 • 247 citations

Linking exposure to environmental pollutants with biological effects

2003 • 233 citations

Free radical activity of PM10: iron-mediated generation of hydroxyl radicals.

1997 • 221 citations

Adverse health effects of PM10 particles: involvement of iron in generation of hydroxyl radical.

1996 • 216 citations

Electron paramagnetic resonance study of the generation of reactive oxygen species catalysed by transition metals and quinoid redox cycling by inhalable ambient particulate matter

2005 • 214 citations

Air Pollution Particles Mediated Oxidative DNA Base Damage in a Cell Free System and in Human Airway Epithelial Cells in Relation to Particulate Metal Content and Bioreactivity

2001 • 210 citations

METALS ASSOCIATED WITH BOTH THE WATER-SOLUBLE AND INSOLUBLE FRACTIONS OF AN AMBIENT AIR POLLUTION PARTICLE CATALYZE AN OXIDATIVE STRESS

1999 • 205 citations

Soluble metals as well as the insoluble particle fraction are involved in cellular DNA damage induced by particulate matter.

2002 • 204 citations

The genotoxicity of ambient outdoor air, a review: Salmonella mutagenicity

2004 • 200 citations

Health Risk Assessment of Urban Suspended Particulate Matter with Special Reference to Polycyclic Aromatic Hydrocarbons: A Review

2001 • 198 citations

Hydroxyl radical generation by electron paramagnetic resonance as a new method to monitor ambient particulate matter composition

2003 • 196 citations

Biologic effects induced in vitro by PM10 from three different zones of Mexico City.

2002 • 188 citations

Particulate Matter Induces Alveolar Epithelial Cell DNA Damage and Apoptosis

2003 • 183 citations

Ambient Air Particles: Effects on Cellular Oxidant Radical Generation in Relation to Particulate Elemental Chemistry

1999 • 176 citations

A sensitive method for the detection of mutagenic nitroarenes: construction of nitroreductase-overproducing derivatives of Salmonella typhimurium strains TA98 and TA100

1989 • 174 citations

Inhaled concentrated ambient particles are associated with hematologic and bronchoalveolar lavage changes in canines.

2000 • 164 citations

Temporal variation of hydroxyl radical generation and 8-hydroxy-2′-deoxyguanosine formation by coarse and fine particulate matter

2003 • 159 citations

Pulmonary dysfunction in cystic fibrosis is associated with oxidative stress

1996 • 149 citations

Noninvasive detection of hydroxyl radical generation in lung by diesel exhaust particles

2001 • 148 citations

Heterogeneity of Platinum Group Metals in Airborne Particles

2000 • 146 citations

Biological activities of organic compounds adsorbed onto ambient air particles: comparison between the cities of Teplice and Prague during the summer and winter seasons 2000–2001

2003 • 135 citations

Characterization of particulate, metallic elements of TSP, PM2.5 and PM2.5-10 aerosols at a farm sampling site in Taiwan, Taichung

2003 • 127 citations

Atmospheric Chemistry of Gas-Phase Polycyclic Aromatic Hydrocarbons: Formation of Atmospheric Mutagens

1994 • 127 citations

Particle-bound PAH content in ambient air

1997 • 115 citations

Changes in elemental composition and mass of atmospheric aerosol pollution between 1996 and 2002 in a Central European city

2006 • 114 citations

Physicochemical Characteristics and Biological Activities of Seasonal Atmospheric Particulate Matter Sampling in Two Locations of Paris

2004 • 113 citations

Elemental characterization of PM10, PM2.5 and PM1 in the town of Genoa (Italy)

2005 • 111 citations

Urban airborne particulate: genotoxicity evaluation of different size fractions by mutagenesis tests on microorganisms and comet assay

2001 • 103 citations

Free Radical Activity of PM 10 : Iron-Mediated Generation of Hydroxyl Radicals

1997 • 103 citations

Genotoxicity and physicochemical characteristics of traffic‐related ambient particulate matter

2005 • 99 citations

Cytotoxicity of PM2.5 and PM2.5–10 ambient air pollutants assessed by the MTT and the Comet assays

2000 • 98 citations

Comparative study of the formation of oxidative damage marker 8-hydroxy-2′-deoxyguanosine (8-OHdG) adduct from the nucleoside 2′-deoxyguanosine by transition metals and suspensions of particulate matter in relation to metal content and redox reactivity

2005 • 92 citations

Exhaust emissions from light- and heavy-duty vehicles: chemical composition, impact of exhaust after treatment, and fuel parameters.

1994 • 91 citations

Respiratory muscle function and free radicals: from cell to COPD

2000 • 89 citations

The role of combustion-generated radicals in the toxicity of PM2.5

2000 • 85 citations

Particle-induced oxidative damage is ameliorated by pulmonary antioxidants

2002 • 81 citations

Genotoxicity of urban air pollutants in the Czech Republic

2000 • 79 citations

Genotoxicity of urban air pollutants in the Czech Republic

2000 • 70 citations

Inherent Redox Properties of Diesel Exhaust Particles: Catalysis of the Generation of Reactive Oxygen Species by Biological Reductants

2004 • 69 citations

Genotoxicity of PM10 and extracted organics collected in an industrial, urban and rural area in Flanders, Belgium

2004 • 66 citations

Mutagenic nitroarenes, diesel emissions, particulate-induced mutations and cancer: an essay on cancer-causation by a moving target

1996 • 64 citations

Genotoxicity of fractionated organic material in airborne particles from São Paulo, Brazil

1999 • 63 citations

Correlation between the Amounts of Polycyclic Aromatic Hydrocarbons and Mutagenicity of Airborne Particulate Samples from Taichung City, Taiwan

1998 • 62 citations

Bioactivation of diesel exhaust particle extracts and their major nitrated polycyclic aromatic hydrocarbon components, 1-nitropyrene and dinitropyrenes, by human cytochromes P450 1A1, 1A2, and 1B1

2000 • 62 citations

Chemical and in vitro toxicologic characterization of wintertime and springtime urban-air particles with an aerodynamic diameter below 10 microm in Helsinki.

2004 • 61 citations

Polycyclic aromatic hydrocarbons in ambient air particles in the city of Las Palmas de Gran Canaria

2003 • 59 citations

Development and Application of an Electron Spin Resonance Spectrometry Method for the Determination of Oxygen Free Radical Formation by Particulate Matter

2005 • 59 citations

A genotoxic assessment of environmental tobacco smoke using bacterial bioassays

1989 • 57 citations

Mutagenic activity as a parameter to assess ambient air quality for protection of the environment and human health

2003 • 56 citations

Genotoxicity of environmental air pollution in three European cities: Prague, Košice and Sofia

2004 • 56 citations

Possible Role of Ascorbic Acid in the Oxidative Damage Induced by Inhaled Crystalline Silica Particles

2000 • 55 citations

Distribution of nitropyrenes and mutagenicity in airborne particulates collected with an Andersen sampler

1995 • 55 citations

Mutagenicity of airborne particulate organic material from urban and industrial areas of São Paulo, Brazil

1995 • 52 citations

Particulate matter, PM 10 & PM 2.5 levels, and airborne mutagenicity in Chiang Mai, Thailand

2002 • 51 citations

Assessment of mutagenicity and toxicity of different‐size fractions of air particulates from La Plata, Argentina, and Leipzig, Germany

2002 • 51 citations

Traffic-related platinum and rhodium concentrations in the atmosphere of Rome

2003 • 49 citations

Determination of Source Contributions to Ambient PM_2.5in Kaohsiung, Taiwan, Using a Receptor Model

2001 • 49 citations

Mutagenic activity of airborne particulate matter as an indicative measure of atmospheric pollution

2003 • 48 citations

Frameshift mutations: Relative roles of simple intercalation and of adduct formation

1981 • 46 citations

The variation of street air levels of PAH and other mutagenic PAC in relation to regulations of traffic emissions and the impact of atmospheric processes

1999 • 45 citations

Mutagenicity monitoring of airborne particulate matter (PM10) in the Czech Republic

1999 • 44 citations

Genotoxic and mutagenic activity of environmental air samples in Flanders, Belgium

2004 • 40 citations

DNA binding of polycyclic aromatic hydrocarbons in a human bronchial epithelial cell line treated with diesel and gasoline particulate extracts and benzo[a]pyrene

2003 • 37 citations

A comparative assessment of Boise, Idaho, ambient air fine particle samples using the plate and microsuspension Salmonella mutagenicity assays

2001 • 37 citations

Genotoxic effects of a complex mixture adsorbed onto ambient air particles on human cells in vitro; the effects of Vitamins E and C

2003 • 35 citations

Genotoxicity of size-fractionated samples of urban particulate matter

2005 • 34 citations

Ability of Polymorphonuclear Leukocytes to Generate Active Oxygen Species in Children with Bronchial Asthma

1991 • 32 citations

Genotoxic activity of extractable organic matter from urban airborne particles in Shanghai, China

2002 • 31 citations

Composition and Origin of Airborne Particulate Matterin the Netherlands

2001 • 30 citations

Genotoxicity of organic extracts of airborne particles in somatic cells of Drosophila melanogaster

1999 • 28 citations

ROLE OF DNA REPAIR IN PARTICLE- AND FIBER-INDUCED LUNG INJURY

2002 • 27 citations

Exhaust Emissions from Light- and Heavy-Duty Vehicles: Chemical Composition, Impact of Exhaust after Treatment, and Fuel Parameters

1994 • 23 citations

Assessment of toxicity and mutagenicity in air particulate matter from an urban industrial area in the coast of the Rio de la Plata

2001 • 15 citations

THE MEASUREMENTS OF AMBIENT PARTICULATES (TSP, PM2.5, PM2.5–10), CHEMICAL COMPONENT CONCENTRATION VARIATION, AND MUTAGENICITY STUDY DURING 1998–2001 IN CENTRAL TAIWAN

2002 • 13 citations

Asthma, particulates, and diesel exhaust.

2002 • 12 citations

Mutagenicity and chemical analysis of airborne particulate matter collected in Pisa.

1997 • 12 citations

Study of the Toxicological Mechanism of Acidified Aerosols

2002 • 11 citations

Bioassay of complex mixtures of indoor air pollutants.

1993 • 10 citations

Air quality effects of traffic in a canyon-like street (Falmouth, U.K.).

2003 • 10 citations

Chemical characterization of the PM10 fraction of airborne particulate matter in the urban atmosphere.

1997 • 6 citations

Seasonal Distributions of Acid Components in PM 2.5 Fraction of Airborne Particles in Zagreb Air

2001 • 5 citations

Seasonal Distributions of Acid Components in PM2.5 Fraction of Airborne Particles in Zagreb Air

2001 • 4 citations