The effect of interleukin-1α and the glucocorticoid receptor blocker RU 38486 on total and myofibrillar protein breakdown in skeletal muscle

Methods in Enzymology , Vol

1966 • 26,261 citations

Cachectin/tumor necrosis factor induces cachexia, anemia, and inflammation.

1988 • 745 citations

Stimulation of Muscle Protein Degradation and Prostaglandin E₂Release by Leukocytic Pyrogen (Interleukin-1)

1983 • 689 citations

Muscle Proteolysis Induced by a Circulating Peptide in Patients with Sepsis or Trauma

1983 • 469 citations

Adrenal Steroid Antagonism

1984 • 208 citations

Interleukin 1 and tumor necrosis factor do not regulate protein balance in skeletal muscle

1987 • 200 citations

RU 38486: A potent antiglucocorticoid in vitro and in vivo

1985 • 184 citations

RU 38486: An Original Multifaceted Antihormone in Vivo

1984 • 163 citations

Total and myofibrillar protein breakdown in different types of rat skeletal muscle: Effects of sepsis and regulation by insulin

1989 • 147 citations

Sensitivity of myofibrillar proteins to glucocorticoid-induced muscle proteolysis

1987 • 140 citations

Development of partial tolerance to the gastrointestinal effects of high doses of recombinant tumor necrosis factor-alpha in rodents.

1987 • 132 citations

Activation of protein breakdown and prostaglandin E2 production in rat skeletal muscle in fever is signaled by a macrophage product distinct from interleukin 1 or other known monokines.

1988 • 129 citations

Radioimmunoassay (RIA) of Serum Corticosterone in Rat

1982 • 120 citations

[10] In vitro preparations of the diaphragm and other skeletal muscles

1975 • 118 citations

Tumor necrosis factor can induce fever in rats without activating protein breakdown in muscle or lipolysis in adipose tissue.

1988 • 111 citations

Role of interleukin 1 and tumor necrosis factor on energy metabolism in rabbits

1988 • 105 citations

Blockade of Glucocorticoid Receptor Binding and Inhibition of Dexamethasone-Induced Muscle Atrophy in the Rat by RU38486, a Potent Glucocorticoid Antagonist*

1986 • 84 citations

Interaction between corticosterone and tumor necrosis factor stimulated protein breakdown in rat skeletal muscle, similar to sepsis.

1990 • 78 citations

Effect of the glucocorticoid receptor antagonist RU 38486 on muscle protein breakdown in sepsis.

1991 • 75 citations

Are the Catabolic Effects of Tumor Necrosis Factor Mediated by Glucocorticoids?

1990 • 63 citations

Hemodynamic and metabolic alterations during experimental sepsis in young and adult rats.

1989 • 52 citations

Regulation of total and myofibrillar protein breakdown in rat extensor digitorum longus and soleus muscle incubated flaccid or at resting length

1990 • 48 citations

Is There a Circulating Proteolysis-Inducing Factor During Sepsis?

1990 • 29 citations

Corticosterone alone does not explain increased muscle proteolysis in septic rats

1990 • 21 citations