On the Origin of Bacterial Resistance to Penicillin: Comparison of a β-Lactamase and a Penicillin Target

The structure of β-lactamases

1980 • 1,705 citations

Mechanism of action of penicillins: a proposal based on their structural similarity to acyl-D-alanyl-D-alanine.

1965 • 943 citations

Use of bacteriolytic enzymes in determination of wall structure and their role in cell metabolism.

1968 • 491 citations

ampC cephalosporinase of Escherichia coli K-12 has a different evolutionary origin from that of beta-lactamases of the penicillinase type.

1981 • 384 citations

Use of bacteriolytic enzymes in determination of wall structure and their role in cell metabolism

1968 • 238 citations

Penicillin resistance: the chemistry of .beta.-lactamase inhibition

1985 • 223 citations

Penicillin-binding Proteins and the Future of -Lactam Antibiotics: The Seventh Fleming Lecture

1983 • 203 citations

Structure of a Zn2+-containing D-alanyl-D-alanine-cleaving carboxypeptidase at 2.5 Å resolution

1982 • 123 citations

Occurrence of a serine residue in the penicillin‐binding site of the exocellular DD‐carboxy‐peptidase‐transpeptidase from Streptomyces R61

1976 • 108 citations

β‐Lactamase inhibitors

1983 • 90 citations

2.8-A Structure of penicillin-sensitive D-alanyl carboxypeptidase-transpeptidase from Streptomyces R61 and complexes with beta-lactams.

1985 • 87 citations

The production and molecular properties of the zinc β-lactamase of Pseudomonas maltophilia IID 1275

1985 • 82 citations

Penicillin Target Enzyme and the Antibiotic Binding Site

1982 • 81 citations

Sequences of the active-site peptides of three of the high-Mr penicillin-binding proteins of Escherichia coli K-12.

1985 • 36 citations

5.5 Å crystallographic structure of penicillin β-lactamase and radius of gyration in solution

1976 • 33 citations

Crystallographic data for the β-lactamase from Enterobacter cloacae P99

1983 • 32 citations

Preliminary crystallographic data for β-lactamase I from Bacillus cereus 569

1978 • 23 citations

The crystal structure of β-lactamase from Staphylococcus aureus at 0.5 nm resolution

1985 • 21 citations

Active-site-directed inactivators of the Zn2+-containing <scp>d</scp>-alanyl-<scp>d</scp>-alanine-cleaving carboxypeptidase of Streptomyces albus G

1984 • 17 citations

Crystallization and preliminary X-ray data for the exocellular β-lactamase of Bacillus licheniformis 749/C

1985 • 11 citations

Tertiary and secondary structure analysis of penicillin-binding proteins.

1980 • 9 citations