Preclinical and clinical studies with somatostatin related to the central nervous system

Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone

1973 • 3,509 citations

SMS 201–995: A very potent and selective octapeptide analogue of somatostatin with prolonged action

1982 • 1,317 citations

The Regional Distribution of Somatostatin in the Rat Brain

1975 • 594 citations

N‐terminally extended somatostatin: The primary structure of somatostatin‐28

1980 • 516 citations

Somatostatin in the central nervous system: Physiology and pathological modifications

1986 • 464 citations

CELLULAR LOCALIZATION OF SOMATOSTATIN IN ENDOCRINE-LIKE CELLS AND NEURONS OF THE RAT WITH SPECIAL REFERENCES TO THE A1-CELLS OF THE PANCREATIC ISLETS AND TO THE HYPOTHALAMUS

1975 • 455 citations

Depressant action of TRH, LH-RH and somatostatin on activity of central neurones

1975 • 427 citations

Effects of Somatostatin on the Secretion of Thyrotropin and Prolactin

1974 • 297 citations

The Role of Somatostatin in the Regulation of Anterior Pituitary Hormone Secretion and the Use of Its Analogs in the Treatment of Human Pituitary Tumors

1988 • 271 citations

Striatal neurons containing both somatostatin‐ and avian pancreatic polypeptide (APP)‐like immunoreactivities and NADPH‐diaphorase activity: A light and electron microscopic study

1983 • 267 citations

SOMATOSTATIN IN RAT TISSUES IS DEPLETED BY CYSTEAM.INE ADMINISTRATION1

1981 • 238 citations

Two Types of Somatostatin Receptors Differentiated by Cyclic Somatostatin Analogs

1985 • 228 citations

Somatostatin Augments the M-Current in Hippocampal Neurons

1988 • 206 citations

INHIBITION OF GROWTH HORMONE RELEASE IN HUMANS BY SOMATOSTATIN.

1973 • 204 citations

Somatostatin regulates dopamine release in rat striatal slices and cat caudate nuclei

1983 • 203 citations

Coexistence of somatostatin- and avian pancreatic polypeptide (APP)-like immunoreactivity in some forebrain neurons

1982 • 168 citations

Intrathecal substance P and somatostatin in rats: behaviors indicative of sensation

1983 • 167 citations

Somatostatin in Human Cerebrospinal Fluid

1977 • 153 citations

CENTRAL NERVOUS SYSTEM EFFECTS OF HYPOTHALAMIC PEPTIDES

1975 • 143 citations

MODULATION OF THE TURNOVER RATE OF ACETYLCHOLINE IN RAT BRAIN BY INTRAVENTRICULAR INJECTIONS OF THYROTROPIN‐RELEASING HORMONE, SOMATOSTATIN, NEUROTENSIN AND ANGIOTENSIN II

1978 • 142 citations

‘Barrel rotation’ induced by somatostatin in the non-lesioned rat

1975 • 141 citations

Somatostatin and thyrotropin releasing hormone: Central effect on sleep and motor system

1976 • 141 citations

Effects of vasopressin on active and passive avoidance behavior

1972 • 139 citations

Effect of growth hormone-release inhibiting hormone on hormones stimulating exocrine pancreatic secretion.

1976 • 138 citations

Changes of immunoreactive somatostatin and β-endorphin content in rat brain after amygdaloid kindling

1983 • 123 citations

Localization and characterization of brain somatostatin receptors as studied with somatostatin-14 and somatostatin-28 receptor radioautography

1985 • 120 citations

Involvement of corticotropin-releasing factor in restraint stress-induced anorexia and reversion of the anorexia by somatostatin in the rat

1988 • 113 citations

Central administration of peptides alters thermoregulation in the rabbit

1980 • 112 citations

Somatostatin facilitates the serotonin release from rat cerebral cortex, hippocampus and hypothalamus slices

1981 • 108 citations

Effect of intracerebroventricularly administered somatostatin on brain monoamine turnover

1978 • 104 citations

Proceedings: Effect of somatostatin on motilin levels and gastric emptying.

1975 • 103 citations

Neuroendocrine molecular biology

1987 • 103 citations

Behavioural and motor excitation and inhibition induced by the administration of small and large doses of somatostatin into the amygdala☆

1977 • 92 citations

Cerebrospinal fluid somatostatin and psychiatric illness

1986 • 91 citations

Opiate-like naloxone-reversible actions of somatostatin given intracerebrally

1978 • 91 citations

The Effect of Epidural Somatostatin on Postoperative Pain

1985 • 87 citations

Intrathecal somatostatin modulates spinal sensory and reflex mechanisms: Behavioral and electrophysiological studies in the rat

1985 • 85 citations

Central site of action of somatostatin (SRIF): Role of hippocampus

1976 • 83 citations

Opposite action of oxytocin to vasopressin in passive avoidance behavior in rats

1978 • 82 citations

Cortical administration of somatostatin (SRIF): Effect on sleep and motor behavior

1976 • 79 citations

Peripherally administered somatostatin reduces feeding by a vagal mediated mechanism

1982 • 78 citations

Monoamine metabolites, corticotropin releasing factor and somatostatin as CSF markers in depressed patients

1988 • 78 citations

Cysteamine-Induced Depletion of Brain Somatostatin Is Associated with Up-Regulation of Cerebrocortical Somatostatin Receptors*

1984 • 76 citations

Effects of centrally administered neuropeptide Y (NPY) and NPY13?36 on the brain monoaminergic systems of the rat

1990 • 76 citations

Selective depression of GABA-mediated IPSPs by somatostatin in area CA1 of rabbit hippocampal slices

1989 • 75 citations

Somatostatin selectively inhibits noradrenaline release from hypothalamic neurones

1980 • 72 citations

S0MAT0STATIN-28tl-12)-LIKE IMMUNOREACTIVITY IN THE RAT

1982 • 71 citations

Somatostatin inhibition of adenylate cyclase activity in different brain areas

1989 • 70 citations

Intrathecal Somatostatin in Rats

1988 • 68 citations

Modification of pentobarbital effects by natural and synthetic polypeptides: Dissociation of brain and pituirary effects

1975 • 68 citations

Subpopulations of somatostatin 28-immunoreactive neurons display different vulnerability in senile dementia of the Alzheimer type

1989 • 67 citations

The effect of somatostatin on striatal catecholamines

1984 • 66 citations

The involvement of catecholaminergic mechanisms in the behavioural action of vasopressin

1977 • 64 citations

Isolation and amino acid composition of two somatostatin-like peptides from ovine hypothalamus: Somatostatin-28 and somatostatin-25

1980 • 63 citations

Pharmacological characterization of scratching behaviour induced by intracranial injection of substance p and somatostatin

1981 • 62 citations

Antinociceptive and ‘neurotoxic’ actions of somatostatin in rat spinal cord after intrathecal administration

1988 • 60 citations

Intrathecal Somatostatin in Cat and Mouse Studies on Pain, Motor Behavior, and Histopathology

1989 • 59 citations

The effect of amphetamine on the in vivo release of dopamine, somatostatin and neuropeptide Y from rat caudate nucleus

1987 • 59 citations

Intracerebroventricular somatostatin attenuates electroconvulsive shock-induced amnesia in rats

1983 • 59 citations

Effect of somatostatin on acetylcholine release from rat hippocampal synaptosomes

1979 • 58 citations

Neostriatal administration of somatostatin: differential effect of small and large doses on behavior and motor control

1977 • 56 citations

Somatostatin-like immunoreactivity and somatostatin receptor binding in rat brain before and after pentylenetetrazol-induced convulsion

1986 • 55 citations

Neuropeptides and thermoregulation: The interactions of bombesin, neurotensin, TRH, somatostatin, naloxone and prostaglandins

1982 • 53 citations

Stimulatory effect of somatostatin on norepineprhine release from rat brain cortex slices

1981 • 50 citations

Amygdaloid kindling of rats increases preprosomatostatin mRNA and somatostatin without affecting glutamic acid decarboxylase (GAD) mRNA or GAD

1989 • 49 citations

Somatostatin-28, somatostatin-14 and somatostatin analogs: Effects on thermoregulation

1981 • 45 citations

Opposite effects of centrally administered neuropeptide Y (NPY) on locomotor activity of spontaneously hypertensive (SH) and normal rats

1989 • 44 citations

Effects of intraventricular administration of neurotensin and somatostatin on thermoregulation in the rat

1981 • 43 citations

Inhibitory Action of Somatostatin on Pancreatic α and β Cell Function1

1975 • 43 citations

The somatostatin-28 convertase of rat brain cortex generates both somatostatin-14 and somatostatin-28 (1–12)

1985 • 41 citations

THE PRESENCE OF IMMUNOREACTIVE GROWTH HORMONE RELEASE-INHIBITING HORMONE IN NORMAL CEREBROSPINAL FLUID

1977 • 39 citations

Effects of intracerebroventricularly administered somatostatin on passive avoidance, shuttle-box behaviour and open-field activity in rats

1988 • 38 citations

Molecular mechanisms of anesthesia: progress in anesthesiology, vol. 2

1983 • 37 citations

Effect on memory processes of anti-vasopressin serum microinjected into the dorsal raphe nucleus: The role of catecholaminergic neurotransmission

1980 • 37 citations

Influence of Somatostatin and Growth Hormone-Releasing Factor on Behavior

1988 • 36 citations

Food intake in rats is increased by intracerebroventricular infusion of the somatostatin analogue SMS 201–995 and is decreased by somatostatin antiserum

1988 • 36 citations

Effects of carbamazepine on cerebrospinal fluid somatostatin

1985 • 36 citations

Somatostatin antiserum blocks carbachol-induced increase of paradoxical sleep in the rat

1988 • 35 citations

Antagonistic effect of somatostatin on corticotropin-releasing factor-induced anorexia in the rat

1988 • 35 citations

Long-term effects of cholinergic basal forebrain lesions on neuropeptide Y and somatostatin immunoreactivity in rat neocortex

1989 • 33 citations

Brain and CSF somatostatin concentrations in patients with psychiatric or neurological illness An overview

1988 • 33 citations

Somatostatin in neuropsychiatric disorders

1988 • 33 citations

Effect of Intraventricular Administration of Antisomatostatin γ-Globulin on the Lethal Dose-50 of Strychnine and Pentobarbital in Rats*

1978 • 32 citations

A guide to the clinical use of the somatostatin analogue SMS 201-995 (Sandostatin)

1987 • 31 citations

Comparison between short- and long-term haloperidol administration on somatostatin and substance P concentrations in the rat brain

1988 • 31 citations

Studies of somatostatin-induced barrel rotation in rats

1983 • 31 citations

Pharmacological evidence that somatostatin activates the m-current in hippocampal pyramidal neurons

1988 • 30 citations

Somatostatin in the control of respiration

1998 • 30 citations

Somatostatin(14) and -(28) but not somatostatin(1–12) hyperpolarize CA1 pyramidal neurons in vitro

1988 • 30 citations

CSF somatostatin in anorexia nervosa and bulimia: Relationship to the hypothalamic pituitary-adrenal cortical axis

1988 • 30 citations

Comparative studies with cyclic and linear somatostatin on active avoidance behaviour and open-field activity in rats.

1983 • 30 citations

μ-Opiate binding and morphine antagonism by octapeptide analogs of somatostatin

1987 • 30 citations

Motor disturbances and neurotoxicity induced by centrally administered somatostatin and vasopressin in conscious rats: interactive effects of two neuropeptides

1988 • 28 citations

Beta-endorphin, somatostatin, and prolactin levels in cerebrospinal fluid of epileptic patients after generalised convulsion.

1987 • 28 citations

Immunoreactive Substance P and Somatostatin in the Cerebrospinal Fluid of Senile Parkinsonian Patients

1989 • 28 citations

Cerebrospinal fluid somatostatin correlates with spectral EEG variables and with parietotemporal cognitive dysfunction in Alzheimer patients

1988 • 27 citations

Neuropeptides in psychiatric and neurological disorders

1988 • 26 citations

Somatostatin receptors on cortical neurones and adenohypophysis: comparison between specific binding and adenylate cyclase inhibition

1987 • 25 citations

Comparative studies of somatostatin-14 and some of its fragments on passive avoidance behavior, open field activity and on barrel rotation phenomenon in rats

1989 • 24 citations

Fluphenazine treatment reduces CSF somatostatin in patients with schizophrenia: Correlations with CSF HVA

1989 • 24 citations

The Thyroid Axis, Drugs, and Behavior

1975 • 22 citations

Somatostatin and β-endorphin levels in cerebrospinal fluid of nonmedicated and medicated patients with epileptic seizures

1989 • 21 citations

Somatostatin-like immunoreactivity (SLI) in cisternal cerebrospinal fluid of rats kindled by pentylenetetrazol

1987 • 20 citations

Somatostatin and analogs inhibit endogenous synaptic plasma membrane protein phosphorylation in vitro

1983 • 20 citations

Neurobehavioral effects of intrathecal somatostatinergic treatment in subhuman primates

1988 • 20 citations

Electroencephalographic studies of chlorpromazine methiodide and somatostatin-induced barrel rotation in rats

1983 • 20 citations

Hyperthermic action of somatostatin-28

1983 • 19 citations

Reversal of desipramine-induced suppression of paradoxical sleep by a long-acting somatostatin analogue (octreotide) in rats

1989 • 19 citations

Somatostatin concentrations and binding sites in human frontal cortex are differentially affected in Parkinson's disease associated dementia and in progressive supranuclear palsy

1988 • 19 citations

Developmental change and molecular properties of somatostatin receptors in the rat cerebral cortex

1989 • 18 citations

The effect of linear somatostatin on the active avoidance behaviour and open-field activity on haloperidol, phenoxybenzamine and atropine pretreated rats.

1983 • 18 citations

Role of endogenous somatostatin in the secretion of parathyroid hormone and calcitonin

1979 • 18 citations

Is the effect of somatostatin on muscarinic receptors selective to M1 type?

1986 • 17 citations

A pharmacological approach to the analgesizing mechanism of somatostatin in cluster headache

1987 • 16 citations

Action of Somatostatin on the Central Nervous System

2015 • 16 citations

Excessive grooming induced by somatostatin or its analog SMS 201-995

1987 • 16 citations

Somatostatin-Like Immunoreactivity in Cerebrospinal Fluid of Patients with Complex Partial Epilepsy

1988 • 16 citations

The hypothalamic somatostatinergic pathways mediate feeding behavior in the rat

1989 • 16 citations

Scopolamine-induced suppression of paradoxical sleep is reversed by the somatostatin analogue SMS 201–995 in rats

1988 • 15 citations

Life-Threatening Water Intoxication During Somatostatin Therapy

1987 • 15 citations

Anterior to posterior variations in the concentration of somatostatin-like immunoreactivity in human basal ganglia

1981 • 15 citations

The Analgesic Effect and Development of Dependency to Somatostatin Analogue (Octreoide) in Headache Associated with Acromegaly

1988 • 15 citations

Effects of somatostatin-28 and some of its fragments and analogs on open-field behavior, barrel rotation, and shuttle box learning in rats

1990 • 15 citations

Electroencephalographic and behavioral assessment of intracerebroventricular somatostatin and a substance P analogue

1989 • 14 citations

Lack of effect of chronic carbamazepine on brain somatostatin in the rat

1987 • 14 citations

Suppressive effects of somatostatin in dog Purkinje fibres

1988 • 14 citations

Somatostatin28(15–28), but not somatostatin28(1–12), affects central monoaminergic neurotransmission in rats

1990 • 13 citations

The Levels of Somatostatin in the Brain and CSF of Rat after Carbamazepine Administration

1989 • 12 citations

Biochemical and pharmacological characterization of somatostatin receptors in rat brain.

1989 • 12 citations

Long-term haloperidol treatment decreases somatostatin binding in rat brain

1989 • 10 citations

Somatostatin and Behavior: Preclinical and Clinical Studies

1987 • 10 citations

Diazepam attenuation of somatostatin-induced motor disturbances and neurotoxicity

1988 • 9 citations

AN ELECTROENCEPHALOGRAPHIC INVESTIGATION OF SHORT‐TERM EFFECTS OF THREE HYPOTHALAMIC HORMONES (TRH, LH/FSH‐RH, GH‐RIH) IN NORMAL SUBJECTS

1976 • 9 citations

Distribution of a Somatostatin Analog after Continuous Intraventricular Administration

1989 • 9 citations

Cometary collisions on the Moon and Mercury (reply)

1980 • 8 citations

Somatostatin Inhibits the Isoproterenol-Stimulated Adenylate Cyclase in the Intermediate Lobe of the Male Rat Pituitary Gland

1983 • 7 citations

Short-term recovery of visual field loss in acromegaly during treatment with a long-acting somatostatin analogue

1989 • 7 citations

Effect of somatostatin and its fragments on turning behaviour induced by unilateral substantia nigra lesion in the rat.

1984 • 7 citations

INTERNATIONAL SYMPOSIUM

1988 • 6 citations

Reduced somatostatin-28-(1–12)-like immunoreactivity in cerebral cortex of dogs with an Eck fistula and somatostatin molecular forms in brain

1988 • 6 citations

Direct Inhibitions of Basal and Arginine-Induced Plasma Gastrin Secretion by Somatostatin in Anesthetized Dogs

1976 • 5 citations

Exercise-induced hyperphagia in the hamster is associated with elevated plasma somatostatin-like immunoreactivity

1987 • 5 citations

Effects of somatostatin on self-stimulation behaviour in rats pretreated with a receptor blocker

1988 • 4 citations

Sex-related toxicity of somatostatin and its interaction with pentobarbital and strychnine

1983 • 3 citations

Neuropeptides and psychiatry - basic and clinical aspects

1985 • 3 citations

LOCALLY INJECTED ANTI-VASOPRESSIN SERUM AND PASSIVE AVOIDANCE BEHAVIOR: THE ROLE OF CATECHOLAMINERGIC NEUROTRANSMISSION

1981 • 1 citations

Somatostatin stimulates phosphodiesterase in rat anterior pituitary and brain, and GH4C1 cells.

1988 • 1 citations

Deleted Work

1955 • 0 citations