Somatostatin in neuropsychiatric disorders

Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone

1973 • 3,509 citations

Disrupted 24-hour Patterns of Cortisol Secretion in Psychotic Depression

1973 • 761 citations

Neuroendocrine Regulation in Depression

1976 • 623 citations

The Regional Distribution of Somatostatin in the Rat Brain

1975 • 594 citations

Somatostatin

1983 • 581 citations

The Interrelationship of Growth Hormone (GH)-Releasing Factor and Somatostatin in Generation of the Ultradian Rhythm of GH Secretion^*

1984 • 524 citations

Mismatches between neurotransmitter and receptor localizations in brain: observations and implications

1987 • 524 citations

The immunocytochemical localization of somatostatin-containing neurons in the rat central nervous system

1981 • 487 citations

NEUROBIOLOGY OF MOOD DISORDERS

2017 • 466 citations

Peptide neurons in the vagus, splanchnic and sciatic nerves*

1978 • 443 citations

Reduced amounts of immunoreactive somatostatin in the temporal cortex in senile dementia of Alzheimer type

1980 • 434 citations

Stimulatory and Inhibitory Effects of Purified Hypothalamic Extracts on Growth Hormone Release from Rat Pituitaryin Vitro¹

1968 • 429 citations

Central nervous system effects of hypothalamic hormones and other peptides

1979 • 380 citations

Urinary free Cortisol excretion in depression

1976 • 310 citations

Cortical somatostatin-like immunoreactivity in cases of Alzheimer's disease and senile Dementia of the Alzheimer type

1981 • 274 citations

Neurobiology of Mood Disorders

1985 • 266 citations

Somatostatin immunoreactivity in neuritic plaques of Alzheimer's patients

1985 • 263 citations

Androgen Concentration in Motor Neurons of Cranial Nerves and Spinal Cord

1977 • 263 citations

Is somatostatin an excitatory transmitter in the hippocampus?

1978 • 262 citations

Two Types of Somatostatin Receptors Differentiated by Cyclic Somatostatin Analogs

1985 • 228 citations

Inhibition by Somatostatin on the Release of TSH Induced in Man by Thyrotropin-Releasing Factor

1974 • 227 citations

Regional Brain Concentrations of Neuropeptides in Huntington's Chorea and Schizophrenia

1983 • 223 citations

Rat pre-prosomatostatin. Structure and processing by microsomal membranes.

1983 • 218 citations

Immunohistochemical distribution of pro-somatostatin-related peptides in cerebral cortex

1983 • 216 citations

Location of neuronal tangles in somatostatin neurones in Alzheimer's disease

1985 • 214 citations

Neuropeptides in Alzheimer type dementia

1983 • 214 citations

Somatostatin and ACTH are peptides with partial antagonist-like selectivity for opiate receptors

1976 • 213 citations

Neurochemical activities in human temporal lobe related to aging and Alzheimer-type changes

1981 • 211 citations

Biological Aspects of Alzheimer's Disease

1984 • 203 citations

Altered neuropeptide concentrations in cerebrospinal fluid of psychiatric patients

1982 • 192 citations

CSF Somatostatin in Affective Illness

1983 • 190 citations

Peptides, the limbic lobe and schizophrenia

1983 • 184 citations

Reduced lumbar CSF somatostatin in levels in Alzheimer's disease

1982 • 184 citations

Evidence for two somatostatin-14 receptor types in rat brain cortex

1984 • 179 citations

The distribution and morphological characteristics of the intracortical VIP-positive cell: An immunohistochemical analysis

1984 • 176 citations

Somatostatin and dementia in Parkinson's disease

1983 • 172 citations

Immunohistochemical evidence for the presence of somatostatin, a powerful inhibitory peptide, in some primary sensory neurons

1975 • 170 citations

Effects of Growth Hormone Excess and Deficiency on Hypothalamic Somatostatin Content and Release and on Tissue Somatostatin Distribution*

1981 • 164 citations

Immunohistochemical distribution of pro-somatostatin-related peptides in hippocampus

1982 • 159 citations

Immunocytochemical localization of somatostatin-containing neurons in the rat hypothalamus

1979 • 156 citations

Effects of somatostatin on mammalian cortical neurons in culture: physiological actions and unusual dose response characteristics

1983 • 154 citations

Somatostatin in Human Cerebrospinal Fluid

1977 • 153 citations

Circumscribed changes of the cerebral cortex in neuropsychiatric disorders of later life.

1989 • 148 citations

Seven peptides derived from pro-somatostatin in rat brain

1982 • 146 citations

MODULATION OF THE TURNOVER RATE OF ACETYLCHOLINE IN RAT BRAIN BY INTRAVENTRICULAR INJECTIONS OF THYROTROPIN‐RELEASING HORMONE, SOMATOSTATIN, NEUROTENSIN AND ANGIOTENSIN II

1978 • 142 citations

Hypothalamic and extrahypothalamic distribution of somatostatin-immunoreactive elements in the rat brain

1978 • 142 citations

Somatostatin and thyrotropin releasing hormone: Central effect on sleep and motor system

1976 • 141 citations

The tuberoinfundibular system of the rat as demonstrated by immunohistochemical localization of retrogradely transported wheat germ agglutinin (WGA) from the median eminence

1982 • 137 citations

Effect of Intraventricular Injection of Dopamine, Norepinephrine, Acetylcholine, and 5-Hydroxytryptamine on Immunoreactive Somatostatin Release into Rat Hypophyseal Portal Blood*

1979 • 136 citations

Central actions of somatostatin

1980 • 130 citations

GAMMA-AMINOBUTYRIC ACID CONCENTRATION IN BRAIN TISSUE AT TWO STAGES OF ALZHEIMER'S DISEASE

1988 • 130 citations

Involvement of Corticotropin-Releasing Factor and Somatostatin in Stress-Induced Inhibition of Growth Hormone Secretion in the Rat*

1985 • 129 citations

Somatostatin inhibits multireceptor stimulation of cyclic AMP formation and corticotropin secretion in mouse pituitary tumor cells.

1982 • 125 citations

Low cerebrospinal fluid somatostatin in Parkinson disease

1982 • 124 citations

Changes of immunoreactive somatostatin and β-endorphin content in rat brain after amygdaloid kindling

1983 • 123 citations

Somatostatin — both hormone and neurotransmitter?

1978 • 121 citations

Molecular Genetic Neuroscience

1983 • 121 citations

Localization and characterization of brain somatostatin receptors as studied with somatostatin-14 and somatostatin-28 receptor radioautography

1985 • 120 citations

Reduced cholinesterase activity and somatostatin-like immunoreactivity in the cerebrospinal fluid of patients with dementia of the Alzheimer type

1984 • 117 citations

Alterations in Cerebrospinal Fluid Concentrations of Somatostatinlike Immunoreactivity in Neuropsychiatric Disorders

1986 • 114 citations

Concomitant increase of somatostatin, neuropeptide y and glutamate decar☐ylase in the frontal cortex of rats with decreased seizure threshold

1988 • 109 citations

Investigation of Cerebrospinal Fluid Neuropeptides in Idiopathic Senile Dementia

1981 • 108 citations

Somatostatin facilitates the serotonin release from rat cerebral cortex, hippocampus and hypothalamus slices

1981 • 108 citations

Experimental immunohistochemical studies on the amygdalofugal peptidergic (substance P and somatostatin) fibers in the stria terminals of the rat

1981 • 108 citations

Intracerebroventricular infusion of somatostatin selectively increases paradoxical sleep in rats

1986 • 106 citations

Effects of Brain Lesions and Hypothalamic Deafferentation on Somatostatin Distribution in the Rat Brain

1977 • 106 citations

Effect of intracerebroventricularly administered somatostatin on brain monoamine turnover

1978 • 104 citations

Alzheimer's disease

1987 • 103 citations

Widespread reduction of somatostatin‐like immunoreactivity in the cerebral cortex in Alzheimer's disease

1986 • 102 citations

Central Nervous System Regulation of Adrenocorticotropin Secretion: Role of Somatostatins*

1984 • 101 citations

The hypothalamic ‘tuberoinfundibular’ system of the rat as demonstrated by horseradish peroxidase (HRP) microiontophoresis

1980 • 100 citations

Synthesis and biological actions of prosomatostatin.

1980 • 100 citations

Ovine Corticotropin-Releasing Factor Stimulates Somatostatin Secretion from Cultured Brain Cells*

1983 • 99 citations

Dopamine and norepinephrine stimulate somatostatin release by median eminence fragments

1978 • 94 citations

Effects of neurotransmitters and cyclic AMP on somatostatin release from cultured cerebral cortical cells

1982 • 93 citations

The localization of oxytocin, vasopressin, somatostatin and luteinizing hormone releasing hormone in the rat neurohypophysis

1979 • 93 citations

Behavioural and motor excitation and inhibition induced by the administration of small and large doses of somatostatin into the amygdala☆

1977 • 92 citations

Cerebrospinal fluid somatostatin and psychiatric illness

1986 • 91 citations

Physiology and Pharmacology of LHRH and Somatostatin

1982 • 91 citations

Somatostatin: Mechanism of Action in Pancreatic Islet β-Cells

1981 • 90 citations

Low levels of somatostatin in human CSF mark depressive episodes

1984 • 89 citations

Low somatostatin content in cerebrospinal fluid in multiple sclerosis

2009 • 89 citations

Somatostatin and neuropeptide Y concentrations in pathologically graded cases of huntington's disease

1988 • 88 citations

Effects of carbamazepine and valproic acid on brain immunoreactive somatostatin and γ-aminobutyric acid in amygdaloid-kindled rats

1986 • 86 citations

Somatostatin-immunoreactive fiber projections into the brain stem and the spinal cord of the rat

1981 • 86 citations

Somatostatin depresses excitability in neurons of the solitary tract complex through hyperpolarization and augmentation of IM, a non-inactivating voltage-dependent outward current blocked by muscarinic agonists.

1988 • 84 citations

Somatostatin and vasoactive intestinal polypeptide in postmortem brains from patients with Alzheimer-type dementia

1984 • 84 citations

Central site of action of somatostatin (SRIF): Role of hippocampus

1976 • 83 citations

Profound suppression of kindled seizures by cysteamine: possible role of somatostatin to kindled seizures

1983 • 83 citations

Somatostatin lowers the cytosolic free Ca2+ concentration in clonal rat pituitary cells (GH3 cells)

1984 • 81 citations

Vasoactive intestinal peptide inhibits release of somatostatin from

1979 • 81 citations

Somatostatin inhibits adrenergic and cholinergic neurotransmission in smooth muscle

1978 • 80 citations

Comparative studies with somatostatin and cysteamine in different behavioral tests on rats

1984 • 80 citations

Somatostatin is increased in the nucleus accumbens in Huntington's disease

1984 • 80 citations

Cortical administration of somatostatin (SRIF): Effect on sleep and motor behavior

1976 • 79 citations

Monoamine metabolites, corticotropin releasing factor and somatostatin as CSF markers in depressed patients

1988 • 78 citations

Intrathecal somatostatin in terminally ill patients. A report of two cases

1985 • 78 citations

New Directions in Affective Disorders

1989 • 77 citations

Biochemical mapping of somatostatinergic systems in rat brain: Effects of periventricular hypothalamic and medial basal amygdaloid lesions on somatostatin-like immunoreactivity in discrete brain nuclei

1980 • 77 citations

Selective depression of GABA-mediated IPSPs by somatostatin in area CA1 of rabbit hippocampal slices

1989 • 75 citations

CSF somatostatin‐like immunoreactivity in dementia

1986 • 74 citations

Somatostatin selectively inhibits noradrenaline release from hypothalamic neurones

1980 • 72 citations

Huntington's chorea?Measurements of somatostatin, substance P and Cyclic nucleotides in the cerebrospinal fluid

1981 • 72 citations

Somatostatin Analogs Inhibit Somatostatin Secretion from Cultured Hypothalamus Cells

1984 • 72 citations

Distinct topographical localisation of two somatostatin receptor subpopulations in the human cortex

1987 • 70 citations

Effect of Baclofen Enantiomorphs on the Spinal

1983 • 70 citations

CSF somatostatin in Alzheimer's disease

1984 • 70 citations

Effects of neuroleptic drugs on brain somatostatin-like-immunoreactivity

1984 • 70 citations

Effects of somatostin on food intake in rats

1984 • 69 citations

Studies on the Mechanism of Growth Hormone and Thyrotropin Responses to Somatostatin Antiserum in Anesthetized Rats*

1978 • 69 citations

Somatostatin connections between the hypothalamus and the limbic system of the rat brain

1982 • 68 citations

Cerebrospinal Fluid Somatostatin and Neuropeptide Y

1988 • 65 citations

Somatostatin-like immunoreactivity and substance-P-like immunoreactivity in the CSF of patients with senile dementia of Alzheimer type, multi-infarct syndrome and communicating hydrocephalus

1985 • 62 citations

CSF Somatostatin and Abnormal Response to Dexamethasone Administration in Schizophrenic and Depressed Patients

1986 • 62 citations

Somatostatin content and release measured in cerebral biopsies from demented patients

1987 • 60 citations

CSF somatostatin in patients with Alzheimer's disease, older depressed patients, and age-matched control subjects

1987 • 60 citations

Intracerebroventricular somatostatin attenuates electroconvulsive shock-induced amnesia in rats

1983 • 59 citations

Involvement of Hypothalamic Somatostatin in the Suppression of Growth Hormone Secretion by Central Corticotropin-Releasing Factor in Conscious Male Rats

1985 • 59 citations

Release of Growth Hormone from Purified Somatotrophs: Use of High K⁺and the Ionophore A23187 to Elucidate Interrelations among Ca⁺⁺, Adenosine 3′,5′-Monophosphate, and Somatostatin*

1981 • 58 citations

ALTERED PAIN PERCEPTION AND CEREBROSPINAL ENDORPHINS IN PSYCHIATRIC ILLNESS

1982 • 57 citations

Enzymes processing somatostatin precursors: an Arg-Lys esteropeptidase from the rat brain cortex converting somatostatin-28 into somatostatin-14.

1984 • 55 citations

Beta-endorphin and somatostatin concentrations in the ventricular cerebrospinal fluid of patients with affective disorder

1986 • 55 citations

Radioautographic localization of somatostatin-14 and somatostatin-28 binding sites in the rat brain

1984 • 55 citations

Immunocytochemical localization of somatostatin in human brain

1986 • 54 citations

Decreased somatostatin-like immunoreactivity in cerebral cortex and cerebrospinal fluid in Alzheimer's disease

1987 • 53 citations

Somatostatin: Basic And Clinical Status

2013 • 51 citations

Stimulatory effect of somatostatin on norepineprhine release from rat brain cortex slices

1981 • 50 citations

Amygdaloid kindling of rats increases preprosomatostatin mRNA and somatostatin without affecting glutamic acid decarboxylase (GAD) mRNA or GAD

1989 • 49 citations

Molecular genetic neuroscience

1982 • 48 citations

Elevated CSF somatostatin concentrations in demented patients parallel improved psychomotor functions induced by integrity‐promoting care

1989 • 48 citations

Somatostatin augments the spread of limbic seizures from the hippocampus

1987 • 48 citations

Human cerebrospinal fluid somatostatin in neurologic disease

1985 • 48 citations

Somatostatin-like immunoreactivity in lumbar cerebrospinal fluid from neurohistologically examined demented patients

1984 • 44 citations

Somatostatin immunoreactivity in cortical and some subcortical regions in Alzheimer's disease

1985 • 43 citations

Neuropeptides derived from prosomatostatin that do not contain the somatostatin-14 sequence

1984 • 43 citations

Concentrations of mRNAs encoding for preprosomatostatin and preprocholecystokinin are increased after kainic acid‐induced seizures

1989 • 42 citations

Autoradiographic localization of somatostatin receptors in rat brain

1984 • 42 citations

Neurotransmitters in Alzheimer’s disease

1988 • 40 citations

The influence of hGRF, CRF, TRH and LHRH on SRIF release from median eminence fragments

1985 • 39 citations

Huntington's disease

1986 • 39 citations

Release of Growth Hormone from Purified Somatotrophs: Role of Adenosine 3′,5′-Monophosphate and Guanosine 3′,5′-Monophosphate*

1979 • 38 citations

Food intake in rats is increased by intracerebroventricular infusion of the somatostatin analogue SMS 201–995 and is decreased by somatostatin antiserum

1988 • 36 citations

Effects of carbamazepine on cerebrospinal fluid somatostatin

1985 • 36 citations

Dopamine stimulates rat cortical somatostatin release

1986 • 34 citations

Somatostatin Receptors

1985 • 33 citations

Brain and CSF somatostatin concentrations in patients with psychiatric or neurological illness An overview

1988 • 33 citations

SOMATOSTATIN AND OXYTOCIN INFUSION INHIBITS THE RISE OF PLASMA β‐ENDORPHIN, β‐LIPOTROPHIN AND CORTISOL INDUCED BY INSULIN HYPOGLYCAEMIA

1986 • 32 citations

A Study of Somatostatin Receptors in Amygdaloid‐Kindled Rat Brain

1984 • 31 citations

Release of Growth Hormone (GH) from Purified Somatotrophs: Interaction of GH-Releasing Factor and Somatostatin and Role of Adenosine 3′,5′ -Monophosphate*

1985 • 30 citations

Hypothalamic D₂Receptors Mediate the Preferential Release of Somatostatin-28 in Response to Dopaminergic Stimulation

1986 • 30 citations

Actions of Excitatory Amino Acids on Somatostatin Release from Cortical Neurons in Primary Cultures

1989 • 30 citations

μ-Opiate binding and morphine antagonism by octapeptide analogs of somatostatin

1987 • 30 citations

CSF somatostatin in anorexia nervosa and bulimia: Relationship to the hypothalamic pituitary-adrenal cortical axis

1988 • 30 citations

Prednisone decreases CSF somatostatin in healthy humans: Implications for neuropsychiatric illness

1987 • 29 citations

CSF Neuropeptides in Euthymic Bipolar Patients and Controls

1987 • 29 citations

Beta-endorphin, somatostatin, and prolactin levels in cerebrospinal fluid of epileptic patients after generalised convulsion.

1987 • 28 citations

Effects of haloperidol on somatostatin-like immuno-reactivity in the CSF of schizophrenic patients

1986 • 28 citations

Cerebrospinal fluid somatostatin correlates with spectral EEG variables and with parietotemporal cognitive dysfunction in Alzheimer patients

1988 • 27 citations

Somatostatin: mechanism of action in pancreatic islet beta-cells

1981 • 25 citations

Regional distribution of somatostatin receptor affinity states in rat brain: effects of divalent cations and GTP

1989 • 25 citations

Effect of Anterior Hypothalamic Lesions on Neurohypophysial and Peripheral Tissue Concentrations of Somatostatin in the Rat*

1979 • 25 citations

Fluphenazine treatment reduces CSF somatostatin in patients with schizophrenia: Correlations with CSF HVA

1989 • 24 citations

The regulation of somatostatin production in human medullary thyroid carcinoma cells by dexamethasone.

1986 • 23 citations

Somatostatin-like immunoreactivity and acetylcholinesterase activities in cerebrospinal fluid of patients with Alzheimer disease and senile dementia of the Alzheimer type

1986 • 23 citations

Effects of lesions in the amygdala and periventricular hypothalamus on striatal somatostatin-like immunoreactivity

1985 • 22 citations

Somatostatin inhibits cAMP-dependent and cAMP-independent calcium influx in the clonal pituitary tumor cell line AtT-20 through the same receptor population.

1988 • 22 citations

Trophic Effects of Somatostatin on Calcium Flux: Dynamic Analysis and Correlation with Pituitary Hormone Release*

1986 • 21 citations

Memory improvement with oral physostigmine and lecithin in alzheimers disease

1983 • 21 citations

Carbamazepine lowering effect on CSF somatostatin-like immunoreactivity in temporal lobe epileptics

1986 • 20 citations

Somatostatin regulation of the CRF-ACTH-cortisol axis

1986 • 20 citations

Influence of a benzodiazepine, midazolam, and gamma-aminobutyric acid (GABA) on basal somatostatin secretion from cerebral and diencephalic neurons in dispersed cell culture

1986 • 19 citations

Decrease in Number of Somatostatin Receptors in Rat Brain After Adrenalectomy: Normalization After Glucocorticoid Replacement*

1988 • 18 citations

CSF somatostatin in multiple sclerosis

1987 • 17 citations

Cerebrospinal fluid somatostatin in delirium

1989 • 17 citations

Connections of Medial Preoptic Neurons with the Median Eminence and Amygdala

1981 • 16 citations

Molecular size distribution of somatostatin-like immunoreactivity in the cerebrospinal fluid of patients with degenerative brain disease

1986 • 16 citations

[Neurotransmitters in Alzheimer's disease].

1990 • 14 citations

Somatostatin content and receptors in the cerebral cortex of depressed and control subjects.

1988 • 14 citations

Effect of somatostatin analogues and 17-alpha-dihydroequilin on rat brain opiate receptors.

1978 • 14 citations

Lack of effect of chronic carbamazepine on brain somatostatin in the rat

1987 • 14 citations

CSF somatostatin is elevated in patients with postzoster neuralgia

1988 • 13 citations

The Levels of Somatostatin in the Brain and CSF of Rat after Carbamazepine Administration

1989 • 12 citations

Electrical Stimulation of Several Limbic Areas Suppressed the Growth Hormone (GH) Release Induced by Human Pancreatic GH-Releasing Factor in Pentobarbital-Anesthetized Rats*

1986 • 11 citations

Evidence for the co-localization of somatostatin- and methionine-enkephalin-like immunoreactivities in raphe and gigantocellularis nuclei

1987 • 11 citations

The influence of human corticotropin-releasing hormone on somatostatin secretion in depressed patients and controls

1989 • 11 citations

Prevention of cysteamine-induced myoclonus blocks the long-term inhibition of kindled seizures

1987 • 8 citations

Cerebrospinal fluid somatostatin in primary affective disorder.

1983 • 8 citations

Regulation of Hypothalamic Somatostatin Secretion

1987 • 7 citations

SOMATOSTATIN INHIBITION OF CYCLIC AMP ACCUMULATION AND ADRENOCORTICOTROPIN RELEASE

1984 • 5 citations

HPLC analysis of somatostatin related peptides in putamen of Huntington's Disease patients

1987 • 5 citations

Differential Neuroendocrine Responses to Thyrotropin-Releasing Hormone during Rapid Eye Movement and Slow Wave Sleep in Man*

1981 • 5 citations

Postmortem Investigation of Serotonergic and Peptidergic Hypotheses of Affective Illness

1989 • 2 citations