Cellular effects of reactive intermediates: Nephrotoxicity of S-conjugates of amino acids

Glutathione S-Transferases

1974 • 17,321 citations

The Role of Glutathione and Glutathione S-Transferases in the Metabolism of Chemical Carcinogens and Other Electrophilic Agents

1979 • 1,179 citations

Enzymatic Reaction Mechanisms

1978 • 810 citations

Bioactivation of foreign compounds

1985 • 733 citations

Enzymatic Reaction Mechanisms

1980 • 276 citations

The mutagenic effect of 1,2-dichloroethane on Salmonella typhimurium I. Activation through conjugation with glutathion in vitro

1978 • 247 citations

Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity

1986 • 208 citations

Renal processing of glutathione conjugates

1984 • 171 citations

Renal glutathione transport. Characteristics of the sodium-dependent system in the basal-lateral membrane.

1984 • 171 citations

The role of glutathione conjugation in the mutagenicity of 1,2-dibromoethane

1980 • 159 citations

Cysteine conjugate beta-lyase in rat liver. A novel enzyme catalyzing formation of thiol-containing metabolites of drugs.

1978 • 155 citations

Structure/activity studies of the nephrotoxic and mutagenic action of cysteine conjugates of chlgro and fluoroalkenes

1985 • 154 citations

Evidence for formation of an S-[2-(N7-guanyl)ethyl]glutathione adduct in glutathione-mediated binding of the carcinogen 1,2-dibromoethane to DNA.

1983 • 150 citations

Role of microsomal and cytosolic glutathione S-transferases in the conjugation of hexachloro-1:3-butadiene and its possible relevance to toxicity.

1984 • 135 citations

Renal cysteine conjugate beta-lyase. Bioactivation of nephrotoxic cysteine S-conjugates in mitochondrial outer membrane.

1986 • 122 citations

Chemically Induced Nephrotoxicity: Role of Metabolic Activation

1984 • 110 citations

A pathological study on the toxicity of S-dichlorovinyl-l-cysteine

1965 • 108 citations

Cleavage of S-(1,2-dichlorovinyl)-l-cysteine by an enzyme of bovine origin

1965 • 100 citations

Reactivity of the phosphopyridoxal groups of cystathionase.

1976 • 92 citations

2 Pyridoxal-Linked Elimination and Replacement Reactions

1972 • 80 citations

Uptake of the glutathione conjugate S-(1,2-dichlorovinyl)glutathione by renal basal-lateral membrane vesicles and isolated kidney cells.

1985 • 79 citations

Assay of cysteine conjugate β-lyase activity with S-(2-benzothiazolyl)cysteine as the substrate

1982 • 76 citations

Isolation and characterization of a rat liver enzyme with both cysteine conjugate beta-lyase and kynureninase activity.

1985 • 76 citations

Enzymes of Mercapturic Acid Formation

1980 • 73 citations

Cysteine conjugate beta-lyase.

1983 • 67 citations

Cysteine Conjugate β-Lyase

1980 • 61 citations

Metabolic activation and detoxication of nephrotoxic cysteine and homocysteine S-conjugates.

1986 • 48 citations

Acute amino acid nephrotoxicity.

1983 • 43 citations

Cysteine conjugate β-lyase activities in rat kidney cortex: Subcellular localization and relationship to the hepatic enzyme

1985 • 42 citations

Structure-nephrotoxicity relationships of S-(2-chloroethyl)-DL-cysteine and analogs: role for an episulfonium ion.

1985 • 41 citations

The metabolism of 35S-(1,2-dichlorovinyl)-l-cysteine in the rat

1963 • 40 citations

The inhibition of gamma aminobutyric-alpha-ketoglutaric acid transaminase in vitro and in vivo by amino-oxyacetic acid

1960 • 40 citations

Effect of halogenated vinyl cysteine conjugates on renal tubular active transport

1983 • 36 citations

Correlation of thein vivoandin vitroRenal Toxicity of S-(1,2-Dichlorovinyl)-L-Cysteine

1983 • 35 citations

Biochemical mechanisms of nephrotoxicity.

1985 • 34 citations

Role for an episulfonium ion in S-(2-chloroethyl)-DL-cysteine-induced cytotoxicity and its reaction with glutathione

1987 • 34 citations

Stereochemistry of the glutathione-dependent biotransformation of vicinal-dihaloalkanes to alkenes.

1982 • 32 citations

Chlorotrifluoroethylene nephrotoxicity in rats: A subacute study

1982 • 19 citations

Nephrotoxic Amino Acid and Glutathione S-Conjugates: Formation and Renal Activation

1986 • 15 citations