Evidence for formation of an S-[2-(N7-guanyl)ethyl]glutathione adduct in glutathione-mediated binding of the carcinogen 1,2-dibromoethane to DNA.

FURTHER STUDIES ON THE ALKYLATION OF NUCLEIC ACIDS AND THEIR CONSTITUENT NUCLEOTIDES

1963 • 801 citations

A fluorometric assay for glutathione

1966 • 436 citations

The mutagenic effect of 1,2-dichloroethane on Salmonella typhimurium I. Activation through conjugation with glutathion in vitro

1978 • 247 citations

Induction of Stomach Cancer in Rats and Mice by Halogenated Aliphatic Fumigants

1973 • 193 citations

The role of glutathione conjugation in the mutagenicity of 1,2-dibromoethane

1980 • 159 citations

In vitro activation of 1,2-dichloroethane by microsomal and cytosolic enzymes

1980 • 152 citations

Metabolism of trichloroethylene in isolated hepatocytes, microsomes, and reconstituted enzyme systems containing cytochrome P-450.

1983 • 134 citations

Genotoxic effects of 1,2-dibromoethane and 1,2-dichloroethane

1980 • 118 citations

Macromolecular binding and metabolism of the carcinogen 1,2-dibromoethane.

1978 • 114 citations

Roles of 2-haloethylene oxides and 2-haloacetaldehydes derived from vinyl bromide and vinyl chloride in irreversible binding to protein and DNA.

1981 • 95 citations

Covalent binding of benzidine and N-acetylbenzidine to DNA at the C-8 atom of deoxyguanosine in vivo and in vitro.

1982 • 95 citations

Carcinogenicity and toxicity of 1,2-dibromoethane in the rat

1982 • 92 citations

The metabolism of ethylene dibromide in the rat

1970 • 91 citations

The alkylation of 2′-deoxyguanosine and of thymidine with diazoalkanes. Some observations on O-alkylation

1973 • 73 citations

Isolation of deoxyribonucleic acid and ribosomal ribonucleic acid from rat liver

1968 • 72 citations

Metabolism of benzo(a)pyrene by isolated hepatocytes and factors affecting covalent binding of benzo(a)pyrene metabolites to DNA in hepatocyte and microsomal systems

1980 • 53 citations

Potential industrial carcinogens and mutagens

1980 • 51 citations

The bioactivation of 1,2-dibromoethane in rat hepatocytes: covalent binding to nucleic acids

1982 • 48 citations

In vitro metabolism of 1,2-dihaloethanes to ethylene.

1979 • 46 citations

Metabolism of acrylonitrile by isolated rat hepatocytes.

1983 • 41 citations

Rat liver glutathione S-transferase B: The functional mRNAs specific for the Ya Yc subunits are induced differentially by phenobarbital

1982 • 41 citations

Metabolic activation of 1,2-dibromoethane by glutathione transferase and by microsomal mixed function oxidase: further evidence for formation of two reactive metabolites.

1981 • 39 citations

Alkylation of intracellular and extracellular DNA by dimethylnitrosamine following activation by isolated rat hepatocytes.

1981 • 37 citations