Membrane transport of alkylating agents

Methods in Enzymology , Vol

1966 • 26,261 citations

Partition coefficients and their uses

1971 • 4,444 citations

The Pharmacological Basis of Therapeutics

1976 • 894 citations

Distinct Mediating Systems for the Transport of Neutral Amino Acids by the Ehrlich Cell

1963 • 839 citations

NITROGEN MUSTARD THERAPY

1946 • 654 citations

[53] Quantitative and qualitative analysis of lipids and lipid components

1969 • 559 citations

Comparison of the Sensitivity of Normal Hematopoietic and Transplanted Lymphoma Colony-Forming Cells to Chemotherapeutic Agents Administered <italic>In Vivo</italic><xref ref-type="fn" rid="FN2">2</xref>

1966 • 537 citations

Carrier-mediated Transport of the Folic Acid Analogue, Methotrexate, in the L1210 Leukemia Cell

1968 • 384 citations

Na+ -dependent transport in the intestine and other animal tissues.

1965 • 360 citations

Biological Alkylating Agents

1962 • 355 citations

Use of γ-(4-Nitrobenzyl)pyridine as Analytical Reagent for Ethylenimines and Alkylating Agents

1955 • 348 citations

THE INHIBITION OF ARGINASE BY AMINO ACIDS

1945 • 327 citations

A Distinct Na+-requiring Transport System for Alanine, Serine, Cysteine, and Similar Amino Acids

1967 • 326 citations

MEMBRANE ADENOSINE TRIPHOSPHATASE AND CATION TRANSPORT

1968 • 246 citations

Antineoplastic and Immunosuppressive Agents

1975 • 236 citations

STUDIES OF THE CULTURE OF LEUKEMIC CELLS IN VITRO*

1958 • 223 citations

NITROGEN MUSTARD THERAPY

1949 • 218 citations

Biological Membranes behave as Non-porous Polymeric Sheets with Respect to the Diffusion of Non-electrolytes

1969 • 207 citations

Electrical Counting and Sizing of Mammalian Cells in Suspension

1965 • 201 citations

Studies on the mechanism of action of cytoxan. Evidence of activation in vivo and in vitro.

1961 • 190 citations

Cell Growth and Division

1967 • 187 citations

Carrier-mediated Transport of Choline into Synaptic Nerve Endings

1969 • 186 citations

Mechanism of the Cytotoxic Action of Alkylating Agents in Mammalian Cells and Evidence for the Removal of Alkylated Groups from Deoxyribonucleic Acid

1966 • 184 citations

NITROGEN MUSTARDS IN THE TREATMENT OF NEOPLASTIC DISEASE

1946 • 183 citations

Enzymatic metabolism of cyclophosphamide and nicotine and production of a toxic cyclophosphamide metabolite.

1972 • 183 citations

The Modes of Decomposition of 1,3-Bis(2-chloroethyl)-1-nitrosourea and Related Compounds

1967 • 177 citations

Some Special Kinetic Problems of Transport

1969 • 173 citations

NITROGEN MUSTARD THERAPY

1946 • 172 citations

Defective transport of amethopterin (methotrexate) as a mechanism of resistance to the antimetabolite in L5178Y leukemic cells

1962 • 172 citations

Metabolism of cyclophosphamide

1967 • 158 citations

Metabolism of cyclophosphamide by rat hepatic microsomes.

1971 • 157 citations

Increased levels of folic acid reductase as a mechanism of resistance to amethopterin in leukemic cells

1961 • 152 citations

Melphalan Therapy for Plasma Cell Myeloma

1968 • 147 citations

Comparison of the sensitivity of normal hematopoietic and transplanted lymphoma colony-forming cells to chemotherapeutic agents administered in vivo

1967 • 141 citations

Chapter 16 A Rapid-Mixing Technique to Measure Transport in Suspended Animal Cells: Applications to Nucleoside Transport in Novikpff Rat Hepatoma Cells

1978 • 135 citations

Active carrier-mediated transport of melphalan by two separate amino acid transport systems in LPC-1 plasmacytoma cells in vitro.

1979 • 132 citations

Transport Systems for Neutral Amino Acids in the Pigeon Erythrocyte

1967 • 131 citations

Problems of Cell Permeability

1966 • 129 citations

Contrasts in Neutral Amino Acid Transport by Rabbit Erythrocytes and Reticulocytes

1965 • 126 citations

Repair of Alkylated DNA in Mammalian Cells

1968 • 124 citations

Interaction of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC 79037) with nucleic acids and proteins in vivo and in vitro.

1972 • 122 citations

Approaches to Tumor Chemotherapy

1948 • 113 citations

Kinetic Studies of Transport Across Red Blood Cell Membranes

1974 • 106 citations

Nature of the Cosubstrate Action of Na+ and Neutral Amino Acids in a Transport System

1971 • 106 citations

Analysis of michaelis kinetics for two independent, saturable membrane transport functions

1972 • 106 citations

Evidence for a transport carrier of nitrogen mustard in nitrogen mustard-sensitive and -resistant L5178Y lymphoblasts.

1970 • 102 citations

Cytotoxicity as an indicator for transport mechanism. Evidence that melphalan is transported by two leucine-preferring carrier systems in the L1210 murine leukemia cell

1979 • 100 citations

Neutral amino acid transport systems of tissue culture cells.

1977 • 99 citations

Purine transport in polymorphonuclear leukocytes

1969 • 90 citations

Chemotherapy of Mouse Myeloma: Quantitative Cell Cultures Predictive of Response In Vivo

1973 • 88 citations

Amino acid-conferred protection against melphalan—Characterization of melphalan transport and correlation of uptake with cytotoxicity in cultured L1210 murine leukemia cells

1978 • 87 citations

The Molecular Basis of Simple Diffusion within Biological Membranes

1972 • 82 citations

Transport of Nitrogen Mustard on the Transport-Carrier for Choline in L5178Y Lymphoblasts

1971 • 81 citations

Demographic Profile and Extra Intestinal Manifestations of Ulcerative Colitis in Nepalese population: Study from TUTH a Tertiary Care Centre, Kathmandu, Nepal

2015 • 80 citations

Melphalan in Multiple Myeloma

1967 • 79 citations

Evidence for active transport of melphalan by two amino acid carriers in L5178Y lymphoblasts in vitro.

1979 • 79 citations

Comparison of nitrogen‐mustard‐sensitive and ‐resistant yoshida sarcomas

1966 • 77 citations

Tumour sulphydryl levels and sensitivity to the nitrogen mustard merophan

1963 • 77 citations

On the nature of the “non-saturable” migration of amino acids into Ehrlich cells and into rat jejunum

1966 • 75 citations

Measurement of Size Distributions of Bacterial Cells

1966 • 71 citations

Differences in the in vivo alkylation and cross-linking of nitrogen mustard-sensitive and -resistant lines of Lettré-Ehrlich asites tumors.

1969 • 71 citations

The Treatment of Plasma Cell Myeloma

1967 • 67 citations

Dibasic aminod acid transport in rat-kidney cortex slices

1967 • 63 citations

An Amino Acid Transport System of Unassigned Function in the Ehrlich Ascites Tumor Cell

1965 • 62 citations

Ultrasonic enhancement of nitrogen mustard cytotoxicity in mouse leukemia

1976 • 62 citations

Role of proton dissociation in the transport of acidic amino acids by the Ehrlich ascites tumor cells

1977 • 61 citations

Amino Acid Transport in Kidney

1968 • 60 citations

SUMMARY OF RESULTS OBTAINED WITH NITROGEN MUSTARD IN THE TREATMENT OF NEOPLASTIC DISEASE

1958 • 60 citations

Amino Acid Transport by Isolated Mammalian Renal Tubules

1969 • 59 citations

Amino acid transport in Neurospora crassa. II. Properties of a basic amino acid transport system

1970 • 58 citations

Carbamoylation of amino acid, peptides, and proteins by nitrosoureas.

1975 • 57 citations

Active Transport of Foreign Pyrimidines across the Intestinal Epithelium

1961 • 56 citations

EFFECT OF $beta;-CHLORETHYLAMINE HYDROCHLORIDES IN LEUKqMIA, HODGKIN'S DISEASE, AND POLYCYTHqMIA VERA REPORT ON EIGHTEEN CASES

1947 • 53 citations

Microsomal activation of cyclophosphamide in vivo

1970 • 49 citations

Methane formation in vivo from N-isopropyl α(2-methylhydrazino)-ρ-toluamide hydrochloride, a tumor-inhibiting methylhydrazine derivative

1967 • 47 citations

Nutritional and amethopterin-resistant characteristics of leukemic clones.

1959 • 47 citations

BIOCHEMICAL STUDIES ON 1-AMINOCYCLOPENTANE CARBOXYLIC ACID

1962 • 47 citations

Effects of 1,3-bis(2-chloroethyl)-1-nitrosourea and related compounds on nuclear RNA metabolism.

1974 • 47 citations

Mechanism of uptake of nitrosoureas by L5178Y lymphoblasts in vitro.

1977 • 45 citations

Biochemical Mechanisms of Drug Resistance

1964 • 45 citations

Factors determining cell killing by chemotherapeutic agents In Vivo—II.

1971 • 44 citations

Methods for distinguishing amino acid transport systems of a given cell or tissue.

1966 • 44 citations

A study on the mechanism of resistance to nitrogen mustard (HN2) in Ehrlich ascites tumor cells: comparison of uptake of HN2-14-C into sensitive and resistant cells.

1969 • 43 citations

Evidence for carrier-mediated transport of melphalan by L5178Y lymphoblasts in vitro.

1977 • 42 citations

Uptake of d-Glucose by Renal Tubule Membranes

1972 • 42 citations

Unexpected additional mode of energization of amino-acid transport into Ehrlich cells.

1977 • 40 citations

Further evidence on the nature of microsomal metabolism of procarbazine11Procarbazine, a registered trade name by Hoffman-LaRoche, Nutley, New Jersey. and related alkylhydrazines

1970 • 40 citations

Intestinal absorption of choline in the chick

1973 • 39 citations

Distinguishing between membrane transport and intracellular metabolism of fluorodeoxyuridine in Ehrlich ascites tumor cells by application of kinetic and high performance liquid chromatographic techniques.

1979 • 39 citations

STUDIES WITH MUSTARDS. V. IN VIVO FIXATION OF C14 OF LABELED ALKYLATING AGENTS BY BILATERALLY GROWN SENSITIVE AND RESISTANT TUMORS.

1964 • 39 citations

Studies on the transport and cellular distribution of chlorambucil in the Yoshida ascites sarcoma

1972 • 38 citations

98. The chemistry of 2-chloroalkylamines. Part I. Preparation and general reactions

1947 • 38 citations

Permeability difference as a source of resistance to alkylating agents in Ehrlich tumor cells

1968 • 37 citations

Drug resistance and selectivity. Biochemical and cellular basis

1975 • 37 citations

The effect of nitrogen mustard treatment on the deoxyribonucleic acid of sensitive and resistant Ehrlich tumor cells.

1969 • 34 citations

PROPERTIES OF L5178Y LYMPHOBLASTS HIGHLY RESISTANT TO NITROGEN MUSTARD*

1969 • 34 citations

Sensitivity to nitrogen mustard as a function of transport activity and proliferative rate in L5178Y lymphoblasts.

1971 • 34 citations

Some determinants of camptothecin responsiveness in leukemia L1210 cells.

1971 • 33 citations

The selectivity of action of alkylating agents and drug resistance—III

1970 • 33 citations

The role of drug transport in resistance to nitrogen mustard and other alkylating agents in L518Y lymphoblsts.

1975 • 32 citations

A reassessment of decreased amino acid accumulation by Ehrlich ascites tumor cells in the presence of metabolic inhibitors.

1977 • 32 citations

Metabolism of an antineoplastic methylhydrazine derivative in a P815 mouse neoplasm.

1970 • 32 citations

Mechanism of cyclophosphamide transport by L5178Y lymphoblasts in vitro.

1974 • 32 citations

The effects of nitrogen mustard and dimethyl myleran on murine leukemia cell lines of different radiosensitivity in vitro.

1965 • 31 citations

99. The chemistry of 2-chloroalkylamines. Part II. Reactions of tertiary 2-chloroalkylamines in water

1947 • 31 citations

Versatile Properties of a Nonsaturable, Homogeneous Transport System in Bacillus subtilis: Genetic, Kinetic, and Affinity Labeling Studies

1975 • 29 citations

Amino acid transport by isolated mammalian renal tubules

1970 • 29 citations

Selectivity of action of alkylating agents and drug resistance. 4. Synthesis of tritium-labeled chlorambucil and a study of its cellular uptake by drug-sensitive and drug-resistant strains of the Yoshida ascites sarcoma in vitro

1971 • 28 citations

The action of chemotherapeutic agents at the cellular level and the effects of these agents on hematopoietic and lymphomatous tissue.

1967 • 28 citations

Active transport of nitrogen mustard and choline by normal and leukemic human lymphoid cells.

1972 • 27 citations

Studies of the mode of action of N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide.

1967 • 26 citations

SOME PHARMACOLOGIC PROPERTIES OF A NEW ANTITUMOR AGENT, N-ISOPROPYL-ALPHA-(2-METHYLHYDRAZINO)-P-TOLUAMIDE, HYDROCHLORIDE (NSC-77213).

1964 • 26 citations

Mechanism of Action of Nitrosoureas

1975 • 26 citations

The selectivity of action of alkylating agents and drug resistance. I. Biochemical changes occurring in sensitive and resistant strains of the Yoshida ascites sarcoma following chemotherapy.

1969 • 26 citations

Developmental aspects of cystine transport in rat intestinal segments

1968 • 25 citations

Mechanism of Action of 2-Chloroethylamine Derivatives, Sulfur Mustards, Epoxides, and Aziridines

1975 • 25 citations

Biological alkylating agents : fundamental chemistry and the design of compounds for selective toxicity

1962 • 24 citations

Modes of Uptake of Benzylamine by the Ehrlich Cell

1966 • 24 citations

Binding of 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea to L1210 cell nuclear proteins.

1976 • 22 citations

Alkylating Agents and the Nitrosoureas

1977 • 22 citations

Inhibition of ouabain-H3 uptake by liver slices and its excretion into the bile and by compounds having a steroid nucleus

1969 • 21 citations

Non-Protein Sulphydryl Group in the Original Strain and Sub-line of the Ascites Tumour resistant to Alkylating Reagents

1960 • 20 citations

Human Genetics of Membrane Transport with Emphasis on Amino Acids

1970 • 20 citations

Biological alkylating agents: Fundamental chemistry and the design of compounds for selective toxicity

1963 • 20 citations

Drug-induced stimulation of nitrogen mustard and choline transport and other systems in L5178Y lymphoblasts in vitro.

1974 • 19 citations

Molecular Biology of Alkylation: An Overview

1975 • 19 citations

Kinetics of the accelerated intestinal valine transport in 2-day-old rats

1970 • 18 citations

The effect of insulin on the kinetics of pentose permeation of the rat heart

1970 • 17 citations

Amino acid conferred protection against melphalan interference with melphalan therapy by L-leucine, a competitive substrate for transport

1979 • 16 citations

THE TRANSPORT OF14 C-LABELED NITROGEN MUSTARD N-OXIDE THROUGH CELLULAR MEMBRANE TREATED WITH TWEEN 80 IN VITRO.

1963 • 16 citations

REACTIONS OF CULTURED MAMMALIAN CELLS OF VARYING RADIOSENSITIVITY WITH THE RADIOMIMETIC ALKYLATING AGENT, MUSTARD GAS

1965 • 15 citations

Plasma Pyridoxal Phosphate Depletion by the Carcinostatic Procarbazine

1969 • 15 citations

The Uptake and Utilization of Chlorambucil by Lymphocytes from Patients with Chronic Lymphocytic Leukaemia

1972 • 15 citations

THE TOXICITY OF ALKYL‐BIS(e‐CHLOROETHYL)‐AMINES AND OF THE PRODUCTS OF THEIR REACTION WITH WATER

1946 • 15 citations

Resistance to sulfur mustard: a comparison of some properties of strain L cells and a resistant subline.

1966 • 14 citations

Studies on the biochemical mode of action of a cytotoxic methylhydrazine derivative, N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide.

1966 • 13 citations

Mechanism of resistance of yoshida sarcoma to nitrogen mustard. III. Mechanism of supressed transport of nitrogen mustard

1973 • 12 citations

Accumulation of two alkylating agents, nitrogen mustard and busulfan, by murine leukemia cells in vitro

1969 • 12 citations

Drug-induced stimulation of transport of hydrolyzed nitrogen mustard and choline by normal and leukemic human cells in vitro.

1976 • 11 citations

Mechanism of natural and acquired resistance to methyl-bis(2-chloroethyl)amine N-oxide in ascites tumors. I. Permeability of tumor cells to alkylating agents.

1962 • 11 citations

Nitrogen mustard sensitivity and choline transport in Walker 256 carcinosarcoma cells in vitro.

1973 • 10 citations

Enhancement of melphalan therapy with glutaminase:asparaginase.

1978 • 10 citations

Chemistry of Alkylation

1975 • 8 citations

On the mechanism of uptake of procarbazine byL5178Y lymphoblasts in vitro

1978 • 8 citations

Amino acid conferred protection against melphalan: interference with leucine protection of melphalan cytotoxicity by the basic amino acids in cultured murine L1210 leukemia cells.

1978 • 8 citations

Studies on the Metabolism of Rat Ascites Tumor with Nitrogen Mustard Sensitive and Resistant Strains

1961 • 7 citations

Protection of L5178Y lymphoblasts by choline and ethanolamine against cytocidal effect of nitrogen mustard in vitro.

1973 • 7 citations

Amino acids affecting melphalan transport and cytotoxicity in cultured l1210 cells. Abstr.

1977 • 7 citations

Studies of nitrogen mustard transport by mouse myeloma and hemopoietic precursor cells.

1973 • 7 citations

The kinetics of haemolysis of human erythrocytes in hypotonic solutions of glucose

1968 • 5 citations

Mechanism of Action of Methanesulfonates

1975 • 4 citations

Different inhibitory effect of nitrogen mustard (HN2) and TS-160 (HN3) on choline transport in L 5178Y lymphoblasts.

1975 • 2 citations

Incorporation of Radioactivity into Phospholipid Fractions of L5178Y Lymphoblasts after Treatment with Hydrolyzed Nitrogen-14C Mustard

1973 • 1 citations