Neuroendocrine mechanisms mediating awakening of the human gonadotropic axis in puberty

Approximate entropy as a measure of system complexity.

1991 • 5,411 citations

Variations in the Pattern of Pubertal Changes in Boys

1970 • 4,870 citations

Standards from birth to maturity for height, weight, height velocity, and weight velocity: British children, 1965. II.

1966 • 2,592 citations

The Neuroendocrine Control of the Menstrual Cycle

1980 • 1,288 citations

Origin of luteinizing hormone-releasing hormone neurons

1989 • 1,098 citations

Clinical longitudinal standards for height and height velocity for North American children

1985 • 1,069 citations

THE TEMPORAL RELATIONSHIP BETWEEN GONADOTROPIN RELEASING HORMONE (GnRH) AND LUTEINIZING HORMONE (LH) SECRETION IN OVARIECTOMIZED EWES¹

1982 • 905 citations

Episodic Luteinizing Hormone Secretion in Man PULSE ANALYSIS, CLINICAL INTERPRETATION, PHYSIOLOGIC MECHANISMS

1973 • 715 citations

Serum insulin-like growth factor-I in 1030 healthy children, adolescents, and adults: relation to age, sex, stage of puberty, testicular size, and body mass index

1994 • 696 citations

Luteinizing hormone-releasing hormone (LHRH)-expressing cells do not migrate normally in an inherited hypogonadal (Kallmann) syndrome

1989 • 612 citations

The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations.

1987 • 561 citations

The Physiology of Gonadotropin-Releasing Hormone (GnRH) Secretion in Men and Women

1985 • 489 citations

Pituitary Stalk Portal Blood Collection in Rhesus Monkeys: Evidence for Pulsatile Release of Gonadotropin-Releasing Hormone (GnRH)

1976 • 482 citations

GONADOTROPIN-RELEASING HORMONE AND ITS ANALOGS

1994 • 449 citations

Gonadotropin-Releasing Hormone and Its Analogues

2020 • 419 citations

Simultaneous Measurement of Luteinizing Hormone-Releasing Hormone and Luteinizing Hormone Release in Unanesthetized, Ovariectomized Sheep*

1982 • 389 citations

Induction of Puberty in Men by Long-Term Pulsatile Administration of Low-Dose Gonadotropin-Releasing Hormone

1982 • 354 citations

Experimental Induction of Puberty in the Infantile Female Rhesus Monkey

1980 • 349 citations

Relative importance of growth hormone and sex steroids for the growth at puberty of trunk length, limb length, and muscle width in growth hormone-deficient children

1976 • 340 citations

Spatiotemporal cell expression of luteinizing hormone-releasing hormone in the prenatal mouse: evidence for an embryonic origin in the olfactory placode

1989 • 327 citations

Human Puberty SIMULTANEOUS AUGMENTED SECRETION OF LUTEINIZING HORMONE AND TESTOSTERONE DURING SLEEP

1974 • 315 citations

PREGNANCIES FOLLOWING CHRONIC INTERMITTENT (PULSATILE) ADMINISTRATION OF Gn-RH BY MEANS OF A PORTABLE PUMP (“ZYKLOMAT”) - A NEW APPROACH TO THE TREATMENT OF INFERTILITY IN HYPOTHALAMIC AMENORRHEA

1980 • 313 citations

Contemporary Aspects of Discrete Peak-Detection Algorithms. II. The Paradigm of the Luteinizing Hormone Pulse Signal in Women*

1992 • 287 citations

Females secrete growth hormone with more process irregularity than males in both humans and rats

1996 • 272 citations

Sex Steroid Control of Gonadotropin Secretion in the Human Male. I. Effects of Testosterone Administration in Normal and Gonadotropin-Releasing Hormone-Deficient Men*

1991 • 269 citations

Quantification of hormone pulsatility via an approximate entropy algorithm

1992 • 268 citations

[26] Deconvolution analysis of hormone data

1992 • 265 citations

Endogenous growth hormone secretion and clearance rates in normal boys, as determined by deconvolution analysis: relationship to age, pubertal status, and body mass.

1992 • 259 citations

Approximate entropy: Statistical properties and applications

1992 • 252 citations

Ovarian Function in Chronic Renal Failure: Evidence Suggesting Hypothalamic Anovulation

1980 • 251 citations

Puberty in monkeys is triggered by chemical stimulation of the hypothalamus.

1989 • 250 citations

Reproductive endocrinology

1991 • 230 citations

Enhanced basal and disorderly growth hormone secretion distinguish acromegalic from normal pulsatile growth hormone release.

1994 • 225 citations

Is aromatization of testosterone to estradiol required for inhibition of luteinizing hormone secretion in men?

1975 • 220 citations

Alterations in the Pulsatile Properties of Circulating Growth Hormone Concentrations during Puberty in Boys*

1989 • 220 citations

Gonadotropin-Releasing Hormone: Role of Pulsatile Secretion in the Regulation of Reproduction

1986 • 218 citations

Contemporary Aspects of Discrete Peak-Detection Algorithms. I. The Paradigm of the Luteinizing Hormone Pulse Signal in Men*

1988 • 211 citations

Effects of acidosis on phosphorylation of phospholamban and troponin I in rat cardiac muscle

1996 • 209 citations

Estimation of daily cortisol production and clearance rates in normal pubertal males by deconvolution analysis.

1993 • 207 citations

Food-Restricted, Prepubertal, Female Rats: Rapid Recovery of Luteinizing Hormone Pulsing with Excess Food, and Full Recovery of Pubertal Development with Gonadotropin-Releasing Hormone*

1986 • 206 citations

Pulsatile Gonadotropin Secretion in Women with Hypothalamic Amenorrhea: Evidence that Reduced Frequency of Gonadotropin-Releasing Hormone Secretion Is the Mechanism of Persistent Anovulation*

1985 • 200 citations

Luteinizing Hormone Releasing Hormone (LHRH) in Pituitary Stalk Blood of Rhesus Monkeys: Relationship to Level of LH Release¹

1977 • 193 citations

Role of endogenous opiates in the expression of negative feedback actions of androgen and estrogen on pulsatile properties of luteinizing hormone secretion in man.

1984 • 191 citations

Altered Neuroendocrine Regulation of Gonadotropin Secretion in Women Distance Runners*

1985 • 187 citations

In VivoRelease of Luteinizing Hormone Releasing Hormone Increases with Puberty in the Female Rhesus Monkey*

1989 • 181 citations

Attenuation of luteinizing hormone secretory burst amplitude as a proximate basis for the hypoandrogenism of healthy aging in men.

1992 • 171 citations

Sex Steroid Control of Gonadotropin Secretion in the Human Male. II. Effects of Estradiol Administration in Normal and Gonadotropin-Releasing Hormone-Deficient Men*

1991 • 162 citations

GnRH Secretion throughout the Ovine Estrous Cycle

1987 • 161 citations

Low Dose Pulsatile Gonadotropin-Releasing Hormone in Anorexia Nervosa: A Model of Human Pubertal Development*

1979 • 157 citations

Patterns of Pulsatile Luteinizing Hormone and Follicle-Stimulating Hormone Secretion in Prepubertal (Midchildhood) Boys and Girls and Patients with Idiopathic Hypogonadotropic Hypogonadism (Kallmann's Syndrome): A Study Using an Ultrasensitive Time-Resolved Immunofluorometric Assay

1991 • 139 citations

Metabolic clearance of biologically active luteinizing hormone in man.

1986 • 133 citations

A Comparative Study of the Luteinizing Hormone Releasing Hormone (LHRH) Neuronal Networks in Mammals1

1979 • 130 citations

Testosterone Administration Inhibits Gonadotropin Secretion by an Effect Directly on the Human Pituitary*

1989 • 119 citations

Ontogeny of pulsatile gonadotropin releasing hormone secretion from midchildhood, through puberty, to adulthood in the human male: a study using deconvolution analysis and an ultrasensitive immunofluorometric assay.

1996 • 119 citations

Short- and Long-Term Effects of Clomiphene Citrate on the Pituitary-Testicular Axis

1971 • 114 citations

Serum Luteinizing Hormone Concentrations Increase 100-Fold in Females From 7 Years of Age to Adulthood, as Measured by Time-Resolved Immunofluorometric Assay

1989 • 110 citations

Endocrinology and Metabolism Clinics of North America

2020 • 106 citations

Gonadotropin-Releasing Hormone

1975 • 105 citations

PULSATILE GONADOTROPHIN SECRETION IN HYPERPROLACTINAEMIC AMENORRHOEA AND THE RESPONSE TO BROMOCRIPTINE THERAPY

1982 • 103 citations

Pulsatile and Sexually Dimorphic Secretion of Luteinizing Hormone in the Human Infant on the Day of Birth

1992 • 102 citations

Pulsatile secretion of gonadotropins in early infancy

1981 • 100 citations

The Sites of Action of Ovarian Steroids in the Regulation of LH Secretion

1981 • 99 citations

PUBERTY-RELATED INCREASE IN EPISODIC LHRH RELEASE FROM RAT HYPOTHALAMUSIN VITRO¹

1984 • 95 citations

Negative feedback effects of estrogen on luteinizing hormone-releasing hormone release occur in pubertal, but not prepubertal, ovariectomized female rhesus monkeys.

1993 • 95 citations

LH bioactivity increases more than immunoreactivity during puberty

1980 • 93 citations

Amplitude suppression of the pulsatile mode of immunoradiometric luteinizing hormone release in fasting-induced hypoandrogenemia in normal men.

1993 • 93 citations

Specific Methodological Approaches to Selected Contemporary Issues in Deconvolution Analysis of Pulsatile Neuroendocrine Data

1995 • 91 citations

In VivoBiological Validation and Biophysical Modeling of the Sensitivity and Positive Accuracy of Endocrine Peak Detection. I. The LH Pulse Signal*

1989 • 91 citations

Unexpected responses of the hypothalamic gonadotropin-releasing hormone "pulse generator" to physiological estradiol inputs in the absence of the ovary.

1987 • 91 citations

Successful induction of follicular maturation and ovulation by prolonged treatment with LH-releasing hormone in women with anorexia nervosa

1975 • 90 citations

Increased disorderliness and amplified basal and pulsatile aldosterone secretion in patients with primary aldosteronism.

1995 • 88 citations

Evidence for a Role of Endogenous Estrogen in the Hypothalamic Control of Gonadotropin Secretion in Men*

1985 • 88 citations

Growth hormone secretion patterns in relation to LH and testosterone secretion throughout normal male puberty

1990 • 83 citations

Estradiol modulates the pulsatile secretion of biologically active luteinizing hormone in man.

1987 • 83 citations

Endogenous opiates modulate the pulsatile secretion of biologically active luteinizing hormone in man.

1983 • 81 citations

Secretion rates and short-term patterns of gonadotrophin-releasing hormone, FSH and LH throughout the periovulatory period in the mare

1987 • 77 citations

Adrenarche and skeletal maturation during luteinizing hormone releasing hormone analogue suppression of gonadarche.

1986 • 77 citations

Pubertal Sleep-Wake Patterns of Episodic LH, FSH and Testosterone Release in Twin Boys

1975 • 77 citations

Evolution of Deconvolution Analysis as a Hormone Pulse Detection Method

1995 • 75 citations

Sustained Intermittent Release of Gonadotropin-Releasing Hormone in the Prepubertal Male Rhesus Monkey Induced by N-Methyl-DL-Aspartic Acid

1988 • 73 citations

Evidence for attenuation of hypothalamic gonadotropin-releasing hormone (GnRH) impulse strength with preservation of GnRH pulse frequency in men with chronic renal failure.

1993 • 71 citations

Starvation-Induced Suppression of Pituitary-Testicular Function in Rats is Reversed by Pulsatile Gonadotropin-Releasing Hormone Substitution1

1991 • 69 citations

Pulsatile Secretion of LH and FSH in Prepubertal and Early Pubertal Boys Revealed by Ultrasensitive Time-Resolved Immunofluorometric Assays

1990 • 68 citations

Reversal of fasting-induced suppression of luteinizing hormone (LH) secretion in male rhesus monkeys by intragastric nutrient infusion: evidence for rapid stimulation of LH by nutritional signals.

1993 • 67 citations

LH Measurements by in Vitro Bioassay and a Highly Sensitive Immunofluorometric Assay Improve the Distinction between Boys with Constitutional Delay of Puberty and Hypogonadotropic Hypogonadism

1990 • 64 citations

Evidence that androgen negative feedback regulates hypothalamic gonadotropin-releasing hormone impulse strength and the burst-like secretion of biologically active luteinizing hormone in men.

1992 • 61 citations

In vivo Activity of the LHRH Pulse Generator as Determined with Push-Pull Perfusion of the Anterior Pituitary Gland of Unrestrained Intact and Castrate Male Rats

1987 • 60 citations

Role of Endogenous Opiates in Pubertal Maturation: Opposing Actions of Naltrexone in Prepubertal and Late Pubertal Boys*

1986 • 56 citations

The electrophysiology of the GnRH pulse generator in the rhesus monkey

1989 • 56 citations

Altered pulsatile gonadotropin signaling in nutritional deficiency in the male

1995 • 55 citations

Attenuation of luteinizing hormone secretory burst amplitude as a proximate basis for the hypoandrogenism of healthy aging in men [corrected and republished article originally printed in J Clin Endocrinol Metab 1992 Jul;75(1):52-8]

1992 • 55 citations

Deconvolution Analysis of Neuroendocrine Data: Waveform-Specific and Waveform-Independent Methods and Applications

1994 • 53 citations

Simultaneous Measurement of Gonadotropin-Releasing Hormone, Luteinizing Hormone, and Follicle-Stimulating Hormone in the Orchidectomized Rat*

1988 • 51 citations

Growth hormone secretion patterns in relation to LH and estradiol secretion throughout normal female puberty

1991 • 49 citations

Integrated Concentrations of Luteinizing Hormone and Puberty

1976 • 49 citations

Neuroendocrine Physiology of the Normal Male Gonadal Axis

1993 • 48 citations

Responsiveness of Gonadotropin Secretion to Infusion of an Opiate-Receptor Antagonist in Hypogonadotropic Individuals*

1982 • 46 citations

Metabolic Clearance of Human Follicle-Stimulating Hormone Assessed by Radioimmunoassay, Immunoradiometric Assay, andin VitroSertoli Cell Bioassay*

1991 • 46 citations

Specific Physiological Regulation of Luteinizing Hormone Secretory Events Throughout the Human Menstrual Cycle: New Insights into the Pulsatile Mode of Gonadotropin Release

1990 • 45 citations

Alterations in luteinizing hormone secretory activity in women with insulin-dependent diabetes mellitus and secondary amenorrhea.

1993 • 44 citations

Facilitatory Role of Neuropeptide Y on the Onset of Puberty: Effect of Immunoneutralization of Neuropeptide Yon the Release of Luteinizing Hormone and Luteinizing-Hormone-Releasing Hormone

1990 • 42 citations

Differential responses of biologically active luteinizing hormone secretion in older versus young men to interruption of androgen negative feedback.

1994 • 39 citations

Bioactive Luteinizing Hormone Pituitary Reserves during Normal and Abnormal Male Puberty*

1982 • 39 citations

Specific Regulatory Actions of Dihydrotestosterone and Estradiol on the Dynamics of FSH Secretion and Clearance in Humans

1991 • 38 citations

Estrogen Regulates the Gonadotropin-Releasing Hormone-Stimulated Secretion of Biologically Active Luteinizing Hormone*

1991 • 38 citations

Bioactive LH: A test to discriminate true precocious puberty from premature thelarche and adrenarche

1980 • 37 citations

Actions of estradiol on discrete attributes of the luteinizing hormone pulse signal in man. Studies in postmenopausal women treated with pure estradiol.

1987 • 36 citations

Changes in the kinetics and biopotency of luteinizing hormone in hemodialyzed men during treatment with recombinant human erythropoietin.

1994 • 32 citations

Androgen-Receptor Blockade Enhances Pulsatile Luteinizing Hormone Production in Late Pubertal Males: Evidence for a Hypothalamic Site of Physiologic Androgen Feedback Action

1994 • 32 citations

The Hypothalamic Pulse Generator: The Reproductive Core

1990 • 29 citations

The Nature of the Gonadotropin-Releasing Hormone Stimulus-Luteinizing Hormone Secretory Response of Human GonadotrophsIn Vivo*

1989 • 29 citations

In vivo Alterations in the Gonadotropin-Releasing Hormone Pulse Generator and the Secretion and Clearance of Luteinizing Hormone in the Uremic Castrate Rat

1994 • 28 citations

Endogenous Opiates Participate in the Regulation of Pulsatile Luteinizing Hormone Release in an Unopposed Estrogen Milieu: Studies in Estrogen-Replaced, Gonadectomized Patients with Testicular Feminization*

1985 • 28 citations

In VivoBiological Validation and Biophysical Modeling of the Sensitivity and Positive Accuracy of Endocrine Peak Detection. II. The Follicle-Stimulating Hormone Pulse Signal*

1991 • 25 citations

Validation of deconvolution analysis of LH secretion and half-life

1994 • 24 citations

Pulsatile Gonadotropin-Releasing Hormone Treatment in Idiopathic Delayed Puberty*

1986 • 23 citations

Comparison between Spontaneous Gonadotropin Concentration Profiles and Gonadotropin Response to Low-Dose Gonadotropin-Releasing Hormone in Prepubertal and Early Pubertal Boys and Patients with Hypogonadotropic Hypogonadism: Assessment by Using Ultrasensitive, Time-Resolved Immunofluorometric Assay

1992 • 23 citations

Variability of pulsatile luteinizing hormone secretion in young male volunteers

1994 • 22 citations

Pituitary self-priming actions of gonadotropin-releasing hormone. Kinetics of estradiol's potentiating effects on gonadotropin-releasing hormone-facilitated luteinizing hormone and follicle-stimulating hormone release in healthy postmenopausal women.

1986 • 22 citations

Pulsatile Release of Bioactive Luteinizing Hormone in Prepubertal Girls: Discordance with Immunoreactive Luteinizing Hormone Pulses

1987 • 21 citations

Differential Regulation of Serum Immunoreactive Luteinizing Hormone and Bioactive Follicle-Stimulating Hormone by Testosterone in Early Pubertal Boys*

1990 • 21 citations

Modulation of Immunoradiometric and Bioactive Follicle Stimulating Hormone Secretion and Clearance in Young and Elderly Men During Treatment with Tamoxifen or Flutamide

1992 • 19 citations

Effects of opioid receptor blockade on luteinizing hormone (LH) pulses and interpuise LH concentrations in normal women during the early phase of the menstrual cycle

1992 • 19 citations

Physiological attributes of endogenous bioactive luteinizing hormone secretory bursts in man

1989 • 18 citations

Nature of gonadotropin-releasing hormone self-priming of luteinizing hormone secretion during the normal menstrual cycle

1990 • 17 citations

Estradiol amplifies the amount of luteinizing hormone (LH) secreted in response to increasing doses of gonadotropin-releasing hormone by specifically augmenting the duration of evoked LH secretory events and hence their mass.

1993 • 15 citations

Gonadotropin-Releasing Hormone

1977 • 14 citations

Pulsatile Hormone Release as a Window into the Brainʼs Control of the Anterior Pituitary Gland in Health and Disease

1994 • 13 citations

The Effect of Long‐Term: Opiate Antagonist Administration to Pubertal Boys

1987 • 13 citations

Estrogenic Modulation of the Gonadotropin-Releasing Hormone-Stimulated Secretory Activity of the Gonadotrope and Lactotrope in Prepubertal Females with Turner's Syndrome*

1991 • 11 citations

Reanalysis of the rat proestrous LH surge by deconvolution analysis

1993 • 9 citations

Nature of gonadotropin-releasing hormone self-priming of luteinizing hormone secretion during the normal menstrual cycle

1991 • 8 citations

330 BIOACTIVE AND IMMUNOREACTIVE SERUM LH IN NORMAL PREPUBERTAL AND PUBERTAL BOYS

1978 • 7 citations

Androgenic and Estrogenic Control of the Self-Priming Effect of LHRH in the Castrated Male Rat

1986 • 6 citations

Gonadotropin Control of Spermatogenesis in Man: Studies of Gonadotropin Administration in Spontaneous and Experimentally Induced Hypogonadotropic States ^a

1984 • 6 citations

Computer Algorithms for Deconvolution-Based Assessment of in Vivo Neuroendocrine Secretory Events

1992 • 5 citations

The effects of pulsatile GnRH infusion upon the diurnal variations in serum LH and testosterone in pre-pubertal and pubertal boys

1989 • 4 citations

Mass Mutation in Zea mays

1918 • 2 citations