Estradiol amplifies the amount of luteinizing hormone (LH) secreted in response to increasing doses of gonadotropin-releasing hormone by specifically augmenting the duration of evoked LH secretory events and hence their mass.

The pituitary gland secretes in bursts: appraising the nature of glandular secretory impulses by simultaneous multiple-parameter deconvolution of plasma hormone concentrations.

1987 • 561 citations

Luteinizing Hormone-Releasing Hormone Release during the Rat Estrous Cycle and after Ovariectomy, as Estimated with Push-Pull Cannulae*

1982 • 407 citations

Contemporary Aspects of Discrete Peak-Detection Algorithms. II. The Paradigm of the Luteinizing Hormone Pulse Signal in Women*

1992 • 287 citations

Regulation of Pituitary Receptors for Gonadotropin-Releasing Hormone during the Rat Estrous Cycle

1980 • 251 citations

VARIATION OF PITUITARY RESPONSIVENESS TO SYNTHETIC LRF DURING DIFFERENT PHASES OF THE MENSTRUAL CYCLE

1972 • 239 citations

A PRIMING EFFECT OF LUTEINIZING HORMONE RELEASING FACTOR ON THE ANTERIOR PITUITARY GLAND IN THE FEMALE RAT

1974 • 237 citations

Attenuation of luteinizing hormone secretory burst amplitude as a proximate basis for the hypoandrogenism of healthy aging in men.

1992 • 171 citations

Evidence for a Hypothalamic Site of Action of Clomiphene Citrate in Women*

1985 • 151 citations

Strength-Duration Characteristics of Estrogen Effects on Gonadotropin Response to Gonadotropin-Releasing Hormone in Women. II. Effects of Varying Concentrations of Estradiol

1976 • 134 citations

Estradiol Augmentation of Pituitary Responsiveness to Gonadotropin-Releasing Hormone in Women¹

1974 • 113 citations

PRIMING EFFECT OF LUTEINIZING HORMONE RELEASING FACTOR: IN-VITRO AND IN-VIVO EVIDENCE CONSISTENT WITH ITS DEPENDENCE UPON PROTEIN AND RNA SYNTHESIS

1976 • 112 citations

PULSATILE PITUITARY GONADOTROPIN SECRETION DURING MATURATION OF THE DOMINANT FOLLICLE IN MONKEYS: ESTROGEN POSITIVE FEEDBACK ENHANCES THE BIOLOGICAL ACTIVITY OF LH

1981 • 111 citations

The Sites of Action of Ovarian Steroids in the Regulation of LH Secretion

1981 • 99 citations

The Biphasic Pattern in the Feedback Action of Ethinyl Estradiol on the Release of Pituitary FSH and LH*

1971 • 98 citations

Luteinizing Hormone-Releasing Hormone-Induced Luteinizing Hormone Secretion in Vitro: Cyclic Changes in Responsiveness and Self-Priming*

1980 • 91 citations

Modulation of Pituitary Gonadotropin Response to Gonadotropin-Releasing Hormone by Estradiol

1974 • 85 citations

A novel general biophysical model for simulating episodic endocrine gland signaling

1988 • 83 citations

Strength-Duration Characteristics of Estrogen Effects on Gonadotropin Response to Gonadotropin-Releasing Hormone in Women. I. Effects of Varying Duration of Estradiol Administration

1975 • 80 citations

Interactions between 17β-Estradiol and Progesterone in the Control of Luteinizing Hormone and Follicle-Stimulating Hormone Release in Rat Anterior Pituitary Cells in Culture

1981 • 77 citations

Changes in Pituitary Responsiveness to Luteinizing Hormone-Releasing Factor During the Rat Estrous Cycle¹

1974 • 63 citations

Operating behavior of dual or multiple endocrine pulse generators.

1990 • 61 citations

VARIATION IN RESPONSE TO SYNTHETIC LUTEINIZING HORMONE—RELEASING HORMONE (LH‐RH) AT DIFFERENT PHASES OF THE SAME MENSTRUAL CYCLE IN NORMAL WOMEN

1974 • 49 citations

HUMAN LUTEINIZING HORMONE IN MAN: STUDIES OF METABOLISM AND BIOLOGICAL ACTION

1973 • 49 citations

Specific Physiological Regulation of Luteinizing Hormone Secretory Events Throughout the Human Menstrual Cycle: New Insights into the Pulsatile Mode of Gonadotropin Release

1990 • 45 citations

Ovarian Steroids Modulate the Self-Priming Effect of Luteinizing Hormone-Releasing Hormone on Bovine Pituitary Cells in Vitro*

1982 • 36 citations

Actions of estradiol on discrete attributes of the luteinizing hormone pulse signal in man. Studies in postmenopausal women treated with pure estradiol.

1987 • 36 citations

The Self-Priming Effect of Gonadotropin-Releasing Hormone on Luteinizing Hormone Release: Observations Using Rat Anterior Pituitary Fragments and Dispersed Cells Continuously Perifused in Parallel^*

1984 • 29 citations

Changes in Plasma Luteinizing Hormone-Releasing Hormone and Gonadotropin Concentrations during Constant Rate Intravenous Infusion of Luteinizing Hormone-Releasing Hormone in Cyclic Rats*

1978 • 24 citations

OESTRADIOL-17β INCREASES PITUITARY RESPONSIVENESS BY A MECHANISM THAT INVOLVES THE RELEASE AND THE PRIMING EFFECT OF LUTEINIZING HORMONE RELEASING FACTOR

1981 • 22 citations

Modulating actions of estradiol on gonadotropin-releasing hormone—stimulated prolactin secretion in postmenopausal individuals

1987 • 19 citations

Suppression of the Positive Feedback of Estradiol Benzoate on Gonadotropin Secretion by an Inhibitory Analog of Luteinizing Hormone-Releasing Hormone (LRH) in Oophorectomized Rhesus Monkeys: Evidence for a Necessary Synergism between LRH and Estrogens*

1983 • 17 citations

SEPARATE NEGATIVE FEEDBACK EFFECTS OF ESTROGEN ON THE PITUITARY AND THE CENTRAL NERVOUS SYSTEM IN THE OVARIECTOMIZED RHESUS MONKEY

1983 • 11 citations

Responses of luteinizing hormone (LH) and follicle-stimulating hormone levels to exogenous gonadotropin-releasing hormone during the estrogen-induced LH surge in the ovariectomized rhesus monkey

1989 • 5 citations