High Level Expression of the Major Transactivation Domain of the Human Glucocorticoid Receptor in Yeast Cells Inhibits Endogenous Gene Expression and Cell Growth

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

“Western Blotting”: Electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A

1981 • 8,657 citations

How eukaryotic transcriptional activators work

1988 • 1,924 citations

Mechanism of transcriptional activation by Sp1: Evidence for coactivators

1990 • 1,029 citations

Functional dissection of VP16, the trans-activator of herpes simplex virus immediate early gene expression.

1988 • 830 citations

Multiple and cooperative trans-activation domains of the human glucocorticoid receptor

1988 • 705 citations

Negative effect of the transcriptional activator GAL4

1988 • 672 citations

Heme regulates transcription of the CYC1 gene of S. cerevisiae via an upstream activation site

1983 • 667 citations

Direct and selective binding of an acidic transcriptional activation domain to the TATA-box factor TFIID

1990 • 620 citations

Sequence-specific positioning of nucleosomes over the steroid-inducible MMTV promoter.

1987 • 597 citations

The hormone-binding domains of the estrogen and glucocorticoid receptors contain an inducible transcription activation function

1988 • 588 citations

Activators and targets

1990 • 582 citations

Mechanism of action of an acidic transcriptional activator in vitro

1991 • 557 citations

Many Transcription Factors Interact Synergistically with Steroid Receptors

1988 • 517 citations

Colocalization of DNA-binding and transcriptional activation functions in the human glucocorticoid receptor

1987 • 512 citations

Distinctly regulated tandem upstream activation sites mediate catabolite repression of the CYC1 gene of S. cerevisiae

1984 • 501 citations

Yeast MIG1 repressor is related to the mammalian early growth response and Wilms' tumour finger proteins.

1990 • 488 citations

Critical Structural Elements of the VP16 Transcriptional Activation Domain

1991 • 461 citations

A novel mediator between activator proteins and the RNA polymerase II transcription apparatus

1990 • 450 citations

Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement

1987 • 428 citations

The degradation signal in a short-lived protein

1989 • 427 citations

Synergistic action of the glucocorticoid receptor with transcription factors.

1988 • 407 citations

Distinct classes of transcriptional activating domains function by different mechanisms

1990 • 368 citations

Function of a yeast TATA element-binding protein in a mammalian transcription system

1988 • 364 citations

Each of three "TATA elements" specifies a subset of the transcription initiation sites at the CYC-1 promoter of Saccharomyces cerevisiae.

1985 • 342 citations

Agonistic and antagonistic activities of RU486 on the functions of the human progesterone receptor.

1990 • 333 citations

Mammalian Glucocorticoid Receptor Derivatives Enhance Transcription in Yeast

1988 • 315 citations

Selective inhibition of activated but not basal transcription by the acidic activation domain of VP16: Evidence for transcriptional adaptors

1990 • 312 citations

Evidence of DNA: protein interactions that mediate HSV-1 immediate early gene activation by VP16.

1988 • 289 citations

Mechanism of action of a yeast activator: Direct effect of GAL4 derivatives on mammalian TFIID-promoter interactions

1988 • 286 citations

A yeast activity can substitute for the HeLa cell TATA box factor

1988 • 253 citations

Mutations in the glucocorticoid receptor zinc finger region that distinguish interdigitated DNA binding and transcriptional enhancement activities.

1989 • 240 citations

Upstream activation sites of the CYC1 gene of Saccharomyces cerevisiae are active when inverted but not when placed downstream of the "TATA box".

1984 • 204 citations

Domains of the Glucocorticoid Receptor Involved in Specific and Nonspecific Deoxyribonucleic Acid Binding, Hormone Activation, and Transcriptional Enhancement

1987 • 174 citations

Mutational analysis of upstream activation sequence 2 of the CYC1 gene of Saccharomyces cerevisiae: a HAP2-HAP3-responsive site.

1988 • 133 citations

Expression of Functional Chicken Oviduct Progesterone Receptors in Yeast (Saccharomyces Cerevisiae)

1989 • 111 citations

In Vitro Transcription Enhancement by Purified Derivatives of the Glucocorticoid Receptor

1989 • 107 citations

Reconstitution of the vitamin D-responsive osteocalcin transcription unit in Saccharomyces cerevisiae.

1989 • 101 citations

Identification of a yeast protein homologous in function to the mammalian general transcription factor, TFIIA.

1989 • 79 citations

Recombinant human glucocorticoid receptor induces transcription of hormone response genes in vitro.

1990 • 78 citations

Ligand-specific transactivation of gene expression by a derivative of the human glucocorticoid receptor expressed in yeast.

1990 • 77 citations

Yeast GCN4 transcriptional activator protein interacts with RNA polymerase II in vitro.

1989 • 41 citations