Hydrogen exchange identifies native-state motional domains important in protein folding

Spectroscopic Determination of Tryptophan and Tyrosine in Proteins^*

1967 • 3,423 citations

Application of phase sensitive two-dimensional correlated spectroscopy (COSY) for measurements of 1H-1H spin-spin coupling constants in proteins

1983 • 3,150 citations

Solvent-Accessible Surfaces of Proteins and Nucleic Acids

1983 • 2,685 citations

Hydrogen exchange and structural dynamics of proteins and nucleic acids

1983 • 1,329 citations

Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's disease

1988 • 1,098 citations

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

1988 • 1,093 citations

A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors

1988 • 1,052 citations

Structural characterization of folding intermediates in cytochrome c by H-exchange labelling and proton NMR

1988 • 823 citations

Assignment of complex proton NMR spectra via two-dimensional homonuclear Hartmann-Hahn spectroscopy

1985 • 814 citations

Protein Hydration in Aqueous Solution

1991 • 778 citations

The folding of hen lysozyme involves partially structured intermediates and multiple pathways

1992 • 719 citations

Aromatic rings act as hydrogen bond acceptors

1988 • 685 citations

Additivity of mutational effects in proteins

1990 • 652 citations

NMR evidence for an early framework intermediate on the folding pathway of ribonuclease A

1988 • 583 citations

Protein structures in solution by nuclear magnetic resonance and distance geometry

1987 • 569 citations

Ribbon models of macromolecules

1987 • 519 citations

Characterization of a partly folded protein by NMR methods: studies on the molten globule state of guinea pig .alpha.-lactalbumin

1989 • 473 citations

Cooperativity in protein-folding kinetics.

1993 • 470 citations

Cold denaturation of myoglobin

1986 • 408 citations

Cloning and characterization of a cDNA coding for the lipoprotein-associated coagulation inhibitor shows that it consists of three tandem Kunitz-type inhibitory domains.

1988 • 331 citations

Hydrogen exchange and the dynamic structure of proteins

1982 • 308 citations

Structural description of acid-denatured cytochrome c by hydrogen exchange and 2D NMR

1990 • 306 citations

Contribution of hydrogen bonding to the conformational stability of ribonuclease T1

1992 • 273 citations

Characterization of the distribution of internal motions in the basic pancreatic trypsin inhibitor using a large number of internal NMR probes

1983 • 270 citations

A partially folded state of hen egg white lysozyme in trifluoroethanol: structural characterization and implications for protein folding

1993 • 264 citations

A peptide model of a protein folding intermediate

1988 • 252 citations

Demonstration by NMR of folding domains in lysozyme

1991 • 246 citations

Thermodynamics of protein denaturation. Calorimetric study of the reversible denaturation of chymotrypsinogen and conclusions regarding the accuracy of the two-state approximation

1970 • 224 citations

Comparison of two highly refined structures of bovine pancreatic trypsin inhibitor

1987 • 210 citations

Structure of form III crystals of bovine pancreatic trypsin inhibitor

1987 • 200 citations

An Antibody Binding Site on Cytochrome C Defined by Hydrogen Exchange and Two-Dimensional NMR

1990 • 187 citations

Hydrogen exchange in native and denatured states of hen egg‐white lysozyme

1992 • 168 citations

Packing defects, cavities, volume fluctuations, and access to the interior of proteins. Including some general comments on surface area and protein structure

1979 • 143 citations

Hydrogen isotope exchange kinetics of single protons in bovine pancreatic trypsin inhibitor

1980 • 126 citations

Protein folding kinetics by combined use of rapid mixing techniques and NMR observation of individual amide protons

1986 • 121 citations

Kinetics of the exchange of individual amide protons in the basic pancreatic trypsin inhibitor

1979 • 115 citations

Energetics of repacking a protein interior.

1991 • 111 citations

Structural characterization of monellin in the alcohol-denatured state by NMR: Evidence for .beta.-sheet to .alpha.-helix conversion

1993 • 110 citations

X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid .beta.-protein precursor

1990 • 110 citations

The Influence of a Single Salt Bridge on Static and Dynamic Features of the Globular Solution Conformation of the Basic Pancreatic Trypsin Inhibitor. 1H and 13C Nuclear-Magnetic-Resonance Studies of the Native and the Transaminated Inhibitor

1978 • 104 citations

A nuclear magnetic resonance study of the hydrogen-exchange behaviour of lysozyme in crystals and solution

1991 • 98 citations

MEASUREMENT OF STRUCTURAL AND FREE ENERGY CHANGES IN HEMOGLOBIN BY HYDROGEN EXCHANGE METHODS

1975 • 96 citations

Kinetic analysis of the folding and unfolding of a mutant form of bovine pancreatic trypsin inhibitor lacking the cysteine-14 and -38 thiols

1988 • 84 citations

Basic pancreatic trypsin inhibitor has unusual thermodynamic stability parameters

1983 • 82 citations

[3] Hydrogen—Tritium exchange

1978 • 82 citations

Periodicity of amide proton exchange rates in a coiled-coil leucine zipper peptide

1991 • 80 citations

Assignment of asparagine-44 side-chain primary amide proton NMR resonances and the peptide amide N1H resonance of glycine-37 in basic pancreatic trypsin inhibitor

1987 • 72 citations

Hydrogen‐exchange evidence for distinct structural classes in globular proteins

1985 • 69 citations

Hydrogen kinetics of peptide amide protons at the bovine pancreatic trypsin inhibitor protein-solvent interface

1985 • 66 citations

Studies of Hydrogen Exchange in Proteins

1971 • 66 citations

Crystal structure of a Y35G mutant of bovine pancreatic trypsin inhibitor

1991 • 61 citations

Mechanism of isotope exchange kinetics of single protons in bovine pancreatic trypsin inhibitor

1979 • 55 citations

Determination of the Rate Constants k1 and k2 of the Linderstrøm-Lang Model for Protein Amide Hydrogen Exchange

1993 • 54 citations

Mechanism of surface peptide proton exchange in bovine pancreatic trypsin inhibitor salt effects and O-protonation

1985 • 53 citations

Amide‐proton exchange studies by two‐dimensional correlated ¹H NMR in two chemically modified analogs of the basic pancreatic trypsin inhibitor

1984 • 49 citations

Polypeptide hydration in mixed solvents at low temperatures

1992 • 49 citations

Studies of hydrogen exchange in proteins. VI. Urea effects on ribonuclease exchange kinetics leading to a general model for hydrogen exchange from folded proteins.

1971 • 48 citations

Pancreatic trypsin inhibitor. 1. Preparation and properties

1953 • 44 citations

Hydrogen exchange rates in pancreatic trypsin inhibitor are not correlated to thermal stability in urea

1981 • 43 citations

Hydrogen exchange kinetics of surface peptide amides in bovine pancreatic trypsin inhibitor

1987 • 39 citations

Crevice‐forming mutants of bovine pancreatic trypsin inhibitor: Stability changes and new hydrophobic surface

1993 • 39 citations

Comparison of hydrogen exchange rates for bovine pancreatic trypsin inhibitor in crystals and in solution

1992 • 30 citations

Sequences encoding two trypsin inhibitors occur in strikingly similar genomic environments

1986 • 29 citations

Crevice‐forming mutants in the rigid core of bovine pancreatic trypsin inhibitor: Crystal structures of F22A, Y23A, N43G, and F45A

1993 • 26 citations

Enzymes immobilized as crystals. Hydrogen isotope exchange of crystalline lysozyme

1980 • 23 citations

Hydrogen exchange of primary amide protons in basic pancreatic trypsin inhibitor: evidence for amino group rotation in buried asparagine side chains

1987 • 23 citations

Dynamical factors in protein-protein association

1989 • 13 citations

„Chemische Mutation”︁ durch Aminosäureaustausch im reaktiven Zentrum eines Proteinase‐Inhibitors und Ånderung seiner Hemmspezifität

1981 • 10 citations