Nitric oxide-mediated cytostatic activity on Trypanosoma brucei gambiense and Trypanosoma brucei brucei

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

Continuous Cultivation of Trypanosoma brucei Blood Stream Forms in a Medium Containing a Low Concentration of Serum Protein without Feeder Cell Layers

1989 • 982 citations

L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.

1987 • 958 citations

Macrophage killing of Leishmania parasite in vivo is mediated by nitric oxide from L-arginine.

1990 • 751 citations

Activated macrophages destroy intracellular Leishmania major amastigotes by an L-arginine-dependent killing mechanism.

1990 • 690 citations

Trypanosoma brucei: A rapid “matching” method for estimating the host's parasitemia

1976 • 664 citations

Microbiostatic effect of murine-activated macrophages for Toxoplasma gondii. Role for synthesis of inorganic nitrogen oxides from L-arginine.

1990 • 573 citations

[24] Nitrate reductase from higher plants

1980 • 507 citations

Separation of Trypanosomes from the Blood of Infected Rats and Mice by Anion-exchangers

1968 • 433 citations

Interferon-Gamma, the Activated Macrophage, and Host Defense Against Microbial Challenge

1988 • 428 citations

Macrophage cytotoxicity against schistosomula of Schistosoma mansoni involves arginine-dependent production of reactive nitrogen intermediates.

1989 • 320 citations

Treatment of Visceral Leishmaniasis with Pentavalent Antimony and Interferon Gamma

1990 • 313 citations

Generation of EPR-detectable nitrosyl-iron complexes in tumor target cells cocultured with activated macrophages

1991 • 280 citations

Hypertriglyceridemia associated with Trypanosoma brucei brucei infection in rabbits: Role of defective triglyceride removal

1980 • 260 citations

Carbohydrate Metabolism in Cultured Cells

1986 • 210 citations

Receptors for the host low density lipoproteins on the hemoflagellate Trypanosoma brucei: purification and involvement in the growth of the parasite.

1988 • 169 citations

A transferrin-binding protein of Trypanosoma brucei is encoded by one of the genes in the variant surface glycoprotein gene expression site.

1991 • 126 citations

Carbohydrate Metabolism in African Trypanosomes, with Special Reference to the Glycosome

1986 • 122 citations

Macrophage cytostatic effect on Trypanosoma musculi involves an L-arginine-dependent mechanism.

1991 • 108 citations

Anti-CD4 and anti-CD2 monoclonal antibody infusions in subjects with multiple sclerosis. Immunosuppressive effects and human anti-mouse responses.

1988 • 88 citations

Mitochondrial iron loss from leukemia cells injured by macrophages. A possible mechanism for electron transport chain defects.

1988 • 85 citations

Serum lipoproteins are required for multiplication of Trypanosoma brucei brucei under axenic culture conditions

1989 • 73 citations

Antibody-Dependent Cell-Mediated Cytotoxicity against Parasites

2015 • 70 citations

Antiproliferative activity of gamma-interferon combined with lipopolysaccharide on murine adenocarcinoma: dependence on an L-arginine metabolism with production of nitrite and citrulline.

1989 • 64 citations

Production of interferons during experimental African trypanosomiasis.

1983 • 43 citations

Multilocus isozyme identification of Trypanosoma brucei stocks isolated in Central Africa: evidence for an animal reservoir of sleeping sickness in Congo

1991 • 41 citations

Interaction of African trypanosomes with the immune system

1984 • 38 citations

Non-specific induction of increased resistance in mice toTrypanosoma congolenseandTrypanosoma bruceiby immunostimulants

1979 • 38 citations

Antibody dependent cell-mediated cytotoxicity againstTrypanosoma cruzi

1977 • 35 citations

Attachment and Ingestion of Trypanosoma gambiense to the Rat Macrophage by Specific Antiserum

1974 • 34 citations

The effector function of nitrogen oxides in host defense against parasites

1991 • 30 citations

Human and animal trypanosomiases as world public health problems

1979 • 28 citations

Immunological clearance of 75Se-labelled Trypanosoma brucei in mice. III. Studies in animals with acute infections.

1981 • 26 citations

The macrophage and parasitic protozoa

1983 • 24 citations

The epidemiological importance of the animal reservoir of Trypanosoma brucei gambiense in the Congo. 2. Characterization of the Trypanosoma brucei complex.

1989 • 24 citations

In vitro growth of Trypanosoma musculi in cellfree medium conditioned by rodent macrophages and mercaptoethanol

1980 • 20 citations

In vitro growth of Trypanosoma musculi: Requirements of cells and serum free culture medium

1986 • 13 citations

Hematologic manifestations, diagnosis, and immunopathology of African trypanosomiasis.

1982 • 11 citations

Polyclonal B‐Cell Stimulative and Immunosuppressive Activities at Different Developmental Stages of Trypanosoma gambiense

1988 • 11 citations

Lymphokine Regulation of Macrophage Effector Activities

1988 • 9 citations

Pharmacology of the nitrovasodilators. Antianginal, antihypertensive, and antiplatelet actions.

1991 • 7 citations