Pharmacologically Active Drug Metabolites

Accumulation of Normeperidine, an Active Metabolite of Meperidine, in Patients with Renal Failure or Cancer

1977 • 354 citations

Metabolic studies of allopurinol, an inhibitor of xanthine oxidase

1966 • 327 citations

Increased incidence of isoniazid hepatitis in rapid acetylators: possible relation to hydrazine metabolites

1975 • 301 citations

Methoxyflurane nephrotoxicity. A study of dose response in man

1973 • 286 citations

Serum Drug Concentrations as Therapeutic Guides

1972 • 265 citations

Action of 1,25-Dihydroxycholecalciferol, a Potent, Kidney-Produced Metabolite of Vitamin D₃, in Uremic Man

1972 • 260 citations

The metabolic fate of amphetamine in man and other species

1970 • 247 citations

Renal clearance of oxipurinol, the chief metabolite of allopurinol

1968 • 201 citations

The tissue distribution, metabolism and excretion of lidocaine in rats, guinea pigs, dogs and man.

1972 • 196 citations

Adriamycin metabolism in man. Evidence from urinary metabolites.

1976 • 194 citations

The fate of acetophenetidin in man and methods for the estimation of acetophenetidin and its metabolites in biological material.

1949 • 192 citations

Plasma kinetics of carbamazepine and its epoxide metabolite in man after single and multiple doses

1975 • 187 citations

EFFECTS OF 1,25-DIHYDROXYCHOLECALCIFEROL ON CALCIUM ABSORPTION, MUSCLE WEAKNESS, AND BONE DISEASE IN CHRONIC RENAL FAILURE

1974 • 184 citations

Polymorphic acetylation of procainamide in man

1975 • 181 citations

Isolation and Identification of Morphine 3- and 6-Glucuronides, Morphine 3,6-Diglucuronide, Morphine 3-Ethereal Sulfate, Normorphine, and Normorphine 6-Glucuronide as Morphine Metabolites in Humans

1977 • 136 citations

The fate of acetanilide in man.

1948 • 134 citations

Conversion of cortisone to cortisol and prednisone to prednisolone.

1967 • 133 citations

Absorption, excretion, and metabolism of a new antibacterial agent, nalidixic acid

1964 • 128 citations

Structure-Activity Relationships in Man of Cannabis Constituents, and Homologs and Metabolites of Δ<sup>9</sup>-Tetrahydrocannabinol

1974 • 126 citations

Intravenous Injection in Man of Δ ⁹ -Tetrahydrocannabinol and 11-OH-Δ ⁹ -Tetrahydrocannabinol

1972 • 126 citations

A specific gas-chromatographic method for the measurement of “steady-state” plasma levels of amitriptyline and nortriptyline in patients

1971 • 125 citations

Pharmacology of 4‐hydroxypropranolol, a metabolite of propranolol

1971 • 124 citations

CLOFIBRATE-INDUCED MUSCLE DAMAGE IN PATIENTS WITH CHRONIC RENAL FAILURE

1975 • 122 citations

Concepts in Biochemical Pharmacology

1975 • 122 citations

First‐pass metabolism of imipramine in man

1975 • 121 citations

The metabolic fate of codeine in man.

1955 • 119 citations

Propranolol metabolism in man and dog: mass spectrometric identification of six new metabolites.

1972 • 119 citations

Adriamycin and daunorubicin disposition in the rabbit.

1974 • 115 citations

The convulsant potency of lidocaine and its N-dealkylated metabolites.

1973 • 114 citations

Renal Failure, Drug Pharmacokinetics and Drug Action

1976 • 110 citations

Plasma half-lives, plasma metabolites and anticoagulant efficacies of the enantiomers of warfarin in man

1973 • 109 citations

The effect of N-demethylation on certain pharmacologic actions of morphine, codeine, and meperidine in the mouse.

1954 • 98 citations

Diazepam metabolism during chronic medication

1973 • 98 citations

Some cellular and metabolic considerations relating to the action of quinidine as a prototype antiarrhythmic agent

1964 • 93 citations

Daunorubicin metabolism in acute nonlymphocytic leukemia

1972 • 91 citations

Quantitative determination of imipramine and desipramine in human blood plasma by direct densitometry of thin-layer chromatograms

1973 • 87 citations

Studies of the metabolism of dapsone in man and experimental animals: formation of N-hydroxy metabolites.

1973 • 85 citations

The etiology of methoxyflurane nephrotoxicity.

1974 • 84 citations

Warfarin metabolism in man: identification of metabolites in urine

1970 • 84 citations

The metabolic fate of phenylbutazone (butazolidin) in man.

1955 • 83 citations

Mass Spectrometric Characterization of Carbamazepine-10,11-epoxide,a Carbamazepine Metabolite Isolated from Human Urine

1972 • 82 citations

.beta.-Adrenergic blocking agents. II. Propranolol and related 3-amino-1-naphthoxy-2-propanols

1968 • 81 citations

The possible role of metabolites in therapeutic response to chlorpromazine treatment

1973 • 78 citations

THE METABOLIC FATE OF C14-LABELED CHLORDIAZEPOXIDE IN MAN, IN THE DOG, AND IN THE RAT.

1965 • 77 citations

Potentiation of Acetohexamide Hypoglycemia by Phenylbutazone

1967 • 77 citations

Identification of glycinexylidide in patients treated with intravenous lidocaine

1973 • 71 citations

Metabolic Conversion of Primidone (Mysoline) to Phenobarbital.

1956 • 69 citations

Daunorubicin metabolites in human urine.

1975 • 68 citations

Pharmacokinetics and metabolism of lidocaine in patients with renal failure

1975 • 68 citations

A Guide to Drug Therapy in Renal Failure

1974 • 68 citations

Disposition of acetylmethadol in relation to pharmacologic action

1975 • 68 citations

Absorption, excretion and metabolic fate of chloral hydrate and trichloroethanol.

1954 • 67 citations

Renal Function and Drug Action.

1971 • 67 citations

Pharmacological activity, metabolism, and pharmacokinetics of glycinexylidide

1975 • 67 citations

Pharmacokinetics and biotransformation of chlorpropamide in man

1972 • 65 citations

Metabolism and excretion of digitoxin in man

1974 • 64 citations

Antiarrhythmic efficacy of N‐acetylprocainamide in patients with premature ventricular contractions

1976 • 63 citations

The urinary excretion profile of naltrexone and metabolites in man.

1974 • 62 citations

Plasma concentrations of diazepam and of its metabolite N‐desmethyldiazepam in relation to anxiolytic effect

1974 • 62 citations

The comparative metabolism of phenacetin and N‐acetyl‐p‐aminophenol in man, with particular reference to effects on the kidney

1968 • 62 citations

Metabolism of Flurazepam, a Benzodiazepine, in Man and Dog

1970 • 61 citations

THE THERMOGENIC EFFECT AND METABOLIC FATE OF ETIOCHOLANOLONE IN MAN*

1958 • 58 citations

Determination of chlordiazepoxide hydrochloride (librium) and its major metabolites in plasma by differential pulse polarography

1974 • 56 citations

Acetylation of procainamide in man and its relationship to isonicotinic acid hydrazide acetylation phenotype

1975 • 56 citations

The metabolism of phenacetin in patients with renal disease

1969 • 56 citations

Metabolic disposition of primidone and its metabolites in epileptic subjects after single and repeated administration

1972 • 56 citations

THE FATE OF TESTOSTERONE INFUSED INTRAVENOUSLY IN MAN

1954 • 55 citations

Utility of Clinical Chemical Determinations of Drug Concentrations in Biological Fluids

1971 • 54 citations

In vitro and in vivo laboratory comparison of cephalothin and desacetylcephalothin.

1965 • 54 citations

A comparative pharmacological study of a series of monohydroxylated and methoxylated chlorpromazine derivatives

1965 • 51 citations

Stereospecific synthesis of the 6.beta.-hydroxy metabolites of naltrexone and naloxone

1975 • 49 citations

Pharmacokinetics of acetaminophen elimination by anephric patients.

1976 • 48 citations

N‐mythelated derivatives of barbituric acid, hydantoin and oxazolidinedione used in the treatment of epilepsy

1958 • 47 citations

Critical compilation of terminal half-lives, percent excreted unchanged, and changes of half-life in renal and hepatic dysfunction for studies in humans with references

1975 • 46 citations

Antiepileptic Drugs: Biotransformation, Metabolism, and Serum Half‐Life

1975 • 46 citations

The fate of guanethidine in two hypertensive patients

1970 • 46 citations

Adriamycin Metabolism in Man

1976 • 44 citations

The acute antiarrhythmic and toxic effects in mice and dogs of 2-ethylamino-2',6-'acetoxylidine (L-86), a metabolite of lidocaine.

1971 • 43 citations

Pharmacokinetic Model for Nalidixic Acid in Man II

1966 • 43 citations

Metabolism, Blood Levels and Rate of Excretion of Acetohexamide in Human Subjects

1967 • 43 citations

Warfarin metabolites: the anticoagulant activity and pharmacology of warfarin alcohols.

1973 • 42 citations

N-hydroxylation of 4,4?-diaminodiphenylsulphone (Dapsone) by liver microsomes, and in dogs and humans

1973 • 40 citations

Metabolites of probenecid. Chemical, physical, and pharmacological studies

1972 • 39 citations

Phenylbutazone metabolites: antirheumatic, sodium-retaining and uricosuric effects in man.

1958 • 39 citations

Quantitative determination of thioridazine and nonconjugated thioridazine metabolites in serum and urine of psychiatric patients.

1975 • 38 citations

The absorption and urinary excretion in man of fenfluramine and its main metabolite.

1967 • 38 citations

Plasma concentration of ?-methyldopa and sulphate conjugate after oral administration of methyldopa and intravenous administration of methyldopa and methyldopa hydrochloride ethyl ester

1975 • 37 citations

CARBOHYDRATE METABOLISM IN UREMIA: BLOOD GLUCOSE RESPONSE TO SULFONYLUREA

1967 • 36 citations

Methods of Analysis of Anti-Epileptic Drugs

1974 • 34 citations

Plasma levels of methsuximide and N‐desmethylmethsuximide during methsuximide therapy

1974 • 34 citations

Effect of various chlorpromazine metabolites on amphetamine-induced stereotyped behaviour in the rat

1972 • 34 citations

Identification and renal excretion of probenecid metabolites in man

1970 • 33 citations

A study of the product of demethylation of trimethadione in the control of petit mal epilepsy

1965 • 33 citations

Ion-pair extraction and high-speed liquid chromatography of cephalothin and deacetylcephalothin in human serum and urine.

1973 • 33 citations

A GLC method for estimation of chlorophenoxyisobutyric acid in plasma. Pharmacokinetics of a single oral dose of clofibrate in man

1975 • 32 citations

Central nervous system effects and metabolic disposition of a glycol metabolite of propranolol.

1974 • 32 citations

Disposition of β-methyldigoxin in man

1975 • 30 citations

Effect of Hemodialysis and Renal Failure on Serum and Urine Concentrations of Cephapirin Sodium

1972 • 30 citations

Plasma concentrations of fenfluramine and its metabolite, norfenfluramine, after single and repeated oral administration.

1971 • 30 citations

Metabolism and pharmacokinetics of naloxone.

1973 • 30 citations

Spectrofluorodensitometric Determination of Flurazepam and Its Major Metabolites in Blood

1974 • 28 citations

Conjugation of Methyldopa in Renal Failure

1972 • 26 citations

Hypoglycemic and uricosuric properties of acetohexamide and hydroxyhexamide

1968 • 25 citations

HYPOTENSIVE EFFECT OF METHYLDOPA IN RENAL FAILURE ASSOCIATED WITH HYPERTENSION

1972 • 24 citations

Determination of trichloroethanol at therapeutic and overdose levels in blood and urine by electron capture gas chromatography

1975 • 24 citations

Gas Chromatography of Barbiturates II

1962 • 23 citations

Pharmacokinetic Model for Nalidixic Acid in Man III

1967 • 23 citations

Cephaloglycin and Its Biologically Active Metabolite Desacetylcephaloglycin

1971 • 22 citations

Metabolism of Oral Contraceptives I. Metabolism of Ethynodiol Diacetate in Women

1972 • 21 citations

Norethynodrel metabolites in human plasma and urine.

1972 • 21 citations

Identification and activity of the hydroxy metabolite that accumulates in the plasma of humans intoxicated with glutethimide.

1974 • 20 citations

Ethynodiol diacetate metabolites in human plasma.

1973 • 19 citations

INTRAVENOUS INJECTION IN MAN OF DELTA 9-TETRAHYDROCANNABINOL AND 11-OH-DELTA 9-TETRAHYDROCANNABINOL

1972 • 19 citations

Simultaneous determination of acetylmethanol and its active biotransformation products in human biofluids

1975 • 19 citations

β-Adrenergic Blocking Agents

1971 • 18 citations

Teratogenic and other effects produced in mice by norethynodrel and its 3‐hydroxymetabolites

1970 • 17 citations

The role of the kidney in the elimination of cephapirin in man

1975 • 16 citations

Urinary Excretion and Plasma Levels of Sulphonamides in Patients with Renal Impairment

1970 • 16 citations

PROBLEMS IN THE BIO-ASSAY OF ORALLY ADMINISTERED CEPHALOGLYCIN IN BIOLOGICAL FLUIDS AND METHOD FOR THE DETECTION OF ITS METABOLITE, DESACETYLCEPHALOGLYCIN

1970 • 14 citations

Methsuximide Overdose

1973 • 14 citations

Glutethimide intoxication: plasma levels of glutethimide and a metabolite in humans, dogs and rats.

1972 • 12 citations

Gas-chromatographic simultaneous analysis for glutethimide and an active hydroxylated metabolite in tissues, plasma, and urine.

1974 • 12 citations

The Bioavailability of Meperidine Using Urine Assays for Meperidine and Normeperidine

1975 • 12 citations

Simultaneous Determination of Trimethadione and Its Metabolite, Dimethadione, by Gas—Liquid Chromatography

1971 • 11 citations

Fenfluramine and methylcellulose in the treatment of obesity: the relationship between plasma drug concentrations and therapeutic efficacy.

1975 • 11 citations

Antihypertensive and noradrenaline-depleting effects of guanethidine metabolites

1971 • 11 citations

Pharmacokinetic study of a peripheral analgesic, floctafenin, in man, mouse, rat, and dog.

1975 • 11 citations

Effects of two Metabolites of Norethynodrel on Reproductive Performance of Female Rats

1970 • 9 citations

An open study of mesoridazine (Serentil) in chronic schizophrenics.

1975 • 8 citations

Biotransformation of Drugs to Pharmacologically Active Metabolites

1975 • 8 citations

Leukaemoid reactions associated with fulminating ulcerative colitis

1975 • 7 citations

Studies on the metabolism in man of oxisuran, a differential immunosuppressive drug

1973 • 7 citations

Concentration of Glutethimide and Associated Compounds in Human Serum and Cerebrospinal Fluid After Drug Overdose

1974 • 6 citations

A comparative evaluation of the hypnotic potency of chloral hydrate and trichloroethanol. I. Studies at the Johns Hopkins University School of Medicine. II. Studies at the St. Louis University School of Medicine. III. Studies at Harvard Medical School.

1955 • 6 citations

Difenoxine (R 15403), the active metabolite of diphenoxylate (R 1132). 5. Clinical comparison of difenoxine and diphenoxylate in volunteers and in patients with chronic diarrhea. Double-blind cross-over assessments.

1972 • 5 citations

Renal failure and the action of drugs.

1974 • 4 citations

Pharmacokinetics and biotransformation of chlorpropamide in the rat and dog.

1974 • 4 citations

Metabolic profile of a new immunosuppressive agent, oxisuran: binding, RE stimulation, drug interaction.

1973 • 3 citations

Difenoxine (R 15403), the active metabolite of diphenoxylate (R 1132). 6. Absorption, excretion and metabolism in man.

1972 • 3 citations

Proceedings: The relationship between fenfluramine and norfenfluramine blood levels and anoretic activity in the rat.

1975 • 2 citations

METABOLIC PRODUCTS OF QUINIDINE IN URINE OF VOLUNTEER SUBJECTS AND PATIENTS WITH CHRONIC ATRIAL FIBRILLATION.

1963 • 1 citations