Biotransformation of Drugs to Pharmacologically Active Metabolites

Psychopharmacology. A Review of Progress, 1957-1967

1969 • 844 citations

Effect of antidepressant drugs on the depletion of intraneuronal brain 5-hydroxytryptamine stores caused by 4-methyl-α-ethyl-meta-tyramine

1969 • 645 citations

Effects of some antidepressant drugs on the depletion of intraneuronal brain catecholamine stores caused by 4,α-dimethyl-meta-tyramine

1969 • 417 citations

Biochemical and Histochemical Studies on the Effects of Imipramine‐like Drugs and (+)‐Amphetamine on Central and Peripheral Catecholamine Neurons

1966 • 414 citations

Metabolic studies of allopurinol, an inhibitor of xanthine oxidase

1966 • 327 citations

Inhibition of the uptake of tritiated 5-hydroxytryptamine in brain tissue

1969 • 321 citations

Pharmacology of Benzodiazepines: Laboratory and Clinical Correlations

1967 • 265 citations

Inhibition of the uptake of tritiated catecholamines by antidepressant and related agents

1967 • 252 citations

The effect of imipramine-like drugs and antihistamine drugs on uptake mechanisms in the central noradrenaline and 5-hydroxytryptamine neurons

1971 • 220 citations

The fate of antipyrine in man.

1950 • 215 citations

False Adrenergic Transmitters

1968 • 197 citations

The fate of acetophenetidin in man and methods for the estimation of acetophenetidin and its metabolites in biological material.

1949 • 192 citations

Enzymatic metabolism of cyclophosphamide and nicotine and production of a toxic cyclophosphamide metabolite.

1972 • 183 citations

SALICYLATE INTOXICATION

1960 • 175 citations

Metabolism of cyclophosphamide

1967 • 158 citations

Determination medazepam (Nobrium), diazepam (Valium), and their major biotransformation products in blood and urine by electron capture gas-liquid chromatography

1970 • 158 citations

The conversion of schradan (OMPA) and parathion into inhibitors of cholinesterase by mammalian liver

1955 • 124 citations

Isolation from rat brain of a metabolic product, desmethylimipramine, that mediates the antidepressant activity of imipramine (Tofranil)

1961 • 113 citations

An experimental approach to the problem of disordered lipid metabolism

1963 • 88 citations

Determination of chlordiazepoxide (Librium) and of a metabolite of lactam character in plasma of humans, dogs, and rats by a specific spectrofluorometric micro method

1963 • 87 citations

Hycanthone,¹ a New Active Metabolite of Lucanthone²

1967 • 85 citations

A potent new uricosuric agent, the sulfoxide metabolite of the phenylbutazone analogue, G-25671.

1957 • 84 citations

Pharmacology of the metabolites of chlordiazepoxide and diazepam.

1965 • 77 citations

Metabolic N-Demethylation of Chlordiazepoxide

1966 • 76 citations

Zoxazolamine

1958 • 72 citations

Metabolism of barbiturates in man

1963 • 72 citations

DIFFERENCES IN THE METABOLISM OF DRUGS DEPENDING UPON THEIR ROUTES OF ADMINISTRATION*

1971 • 66 citations

The metabolism of alpha-dl-acetylmethadol in the rat: the identification of the probable active metabolite.

1965 • 65 citations

BIOCHEMICAL PHARMACOLOGICAL CONSIDERATIONS OF PHENYLBUTAZONE AND ITS ANALOGUES

1960 • 60 citations

The nature of the metabolites of acetohexamide in the rat and in the human.

1965 • 60 citations

Metabolic studies of tetrabenazine, a psychotropic drug in animals and man

1966 • 57 citations

Investigation of the Mechanism of Action of Nicotinic Acid on Serum Lipid Levels in Man

1960 • 51 citations

Enzyme induction and inhibition in studies on the pharmacological actions of acetophenetidin.

1966 • 49 citations

5-Methylpyrazole-3-carboxylic Acid. The Potent Hypoglycemic Metabolite of 3,5-Dimethylpyrazole in the Rat

1965 • 47 citations

Metabolism of14C-medazepam hydrochloride in dog, rat and man

1970 • 47 citations

The acute antiarrhythmic and toxic effects in mice and dogs of 2-ethylamino-2',6-'acetoxylidine (L-86), a metabolite of lidocaine.

1971 • 43 citations

The metabolism of diazepam by liver microsomal enzymes of rats and mice

1969 • 43 citations

Metabolism of diazepam in vitro

1968 • 43 citations

The absorption and urinary excretion in man of fenfluramine and its main metabolite.

1967 • 38 citations

The influence of replacement of the N-ethyl group by the cyanoethyl group on the absorption, distribution and metabolism of (±)-ethylamphetamine in man

1972 • 31 citations

The Time-Concentration Curve of Local Anesthetics.

1948 • 31 citations

Prazepam metabolism by man

1970 • 29 citations

Metabolism of diazepam in isolated perfused liver of rat and mouse

1968 • 27 citations

ANTIHYPERTENSIVE EFFECTS OF ALPHA‐METHYLATED CATECHOLAMINE ANALOGUES IN THE RAT*

1967 • 27 citations

Amphetamine concentrations in rat brain and human urine after fenproporex administration

1972 • 23 citations

A study on the hypnotic activity of chloral hydrate.

1962 • 23 citations

METABOLIC BLOCKADE BY METHOXAMINE AND ITS ANALOGS

1967 • 22 citations

II. Distribution and metabolism of morphine and its surrogates.

1968 • 19 citations

The in vivo production of a potent, long-acting hypotensive metabolite from diallylmelamine.

1965 • 18 citations

Effect of imipramine and desipramine on the metabolism of serotonin in midbrain raphe stimulated rats

1972 • 16 citations

Effects of 5-Carboxy-3-Methylisoxazole on Carbohydrate and Fat Metabolism

1966 • 16 citations

6 Anticonvulsant Drugs

1963 • 16 citations

Oxazepam Excretion by Chlordiazepoxide-14C-Dosed Dogs

1967 • 15 citations

Prazepam Metabolites in Dog Urine

1970 • 14 citations

Metabolic demethylation of 3,5-dimethyl-5-ethyl 2,4-oxazolidinedione (paramethadione, paradione).

1955 • 13 citations

Studies on morphine tolerance in mice. I. In vivo N-demethylation of morphine and N- and O-demethylation of codeine.

1967 • 12 citations

Method for Evaluating Diphenoxylate Hydrochloride

1962 • 12 citations

Pharmacological studies on modaline sulphate (W 3207)

1965 • 11 citations

Difenoxine (R 15403), the active metabolite of diphenoxylate (R 1132). 2. Difneozine, a potent, orally active and safe antidiarrheal agent in rats.

1972 • 8 citations

Metabolisierung von Prenylamin (Segontin�)

1968 • 6 citations

The role of microsomal enzymes in the activation and inactivation of modaline sulfate

1966 • 6 citations

Absorption, distribution and excretion of methsuximide in male rats.

1971 • 2 citations

Deleted Work

1955 • 0 citations