Roles of atypical protein kinase C in lysophosphatidic acid‐induced type II adenylyl cyclase activation in RAW 264.7 macrophages

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1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

1992 • 4,454 citations

Protein kinase C and lipid signaling for sustained cellular responses

1995 • 2,527 citations

Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976

1993 • 1,589 citations

Lysophosphatidate-induced cell proliferation: Identification and dissection of signaling pathways mediated by G proteins

1989 • 846 citations

Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex.

1996 • 727 citations

Lysophosphatidic Acid, a Multifunctional Phospholipid Messenger

1995 • 592 citations

Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1‐phosphate

1998 • 516 citations

Lysophosphatidic acid: G-protein signalling and cellular responses

1997 • 492 citations

Phosphatidic acid activation of protein kinase C-ζ overexpressed in COS cells: comparison with other protein kinase C isotypes and other acidic lipids

1994 • 308 citations

Lysophosphatidic acid, but not phosphatidic acid, is a potent Ca2(+)-mobilizing stimulus for fibroblasts. Evidence for an extracellular site of action.

1990 • 264 citations

Molecular Cloning of the Human Edg2 Protein and Its Identification as a Functional Cellular Receptor for Lysophosphatidic Acid

1997 • 232 citations

Endothelial Cell Inflammatory Responses to Tumor Necrosis Factor α

1996 • 232 citations

Lysophosphatidic acid induces neuronal shape changes via a novel, receptor-mediated signaling pathway: similarity to thrombin action.

1993 • 210 citations

Identification of a putative membrane receptor for the bioactive phospholipid, lysophosphatidic acid.

1992 • 199 citations

Lysophosphatidic Acid‐Induced Neurite Retraction in PC12 Cells: Control by Phosphoinositide‐Ca²⁺ Signaling and Rho

1996 • 198 citations

Molecular cloning of a high-affinity receptor for the growth factor-like lipid mediator lysophosphatidic acid from Xenopus oocytes

1996 • 173 citations

Phorbol ester-induced stimulation and phosphorylation of adenylyl cyclase 2.

1994 • 159 citations

Evidence for Rho-mediated Agonist Stimulation of Phospholipase D in Rat1 Fibroblasts

1996 • 149 citations

Protein Kinase C Alters the Responsiveness of Adenylyl Cyclases to G Protein α and βγ Subunits

1996 • 138 citations

Lysophosphatidic Acid‐Induced Neurite Retraction in PC12 Cells: Neurite‐Protective Effects of Cyclic AMP Signaling

1996 • 137 citations

Signalling properties of lysophosphatidic acid

1993 • 112 citations

Lysophosphatidic acid induces a pertussis toxin-sensitive Ca(2+)-activated Cl- current in Xenopus laevis oocytes

1992 • 84 citations

Decanoyl lysophosphatidic acid induces platelet aggregation through an extracellular action. Evidence against a second messenger role for lysophosphatidic acid

1985 • 76 citations

Distinct PKC isoforms mediate the activation of cPLA₂ and adenylyl cyclase by phorbol ester in RAW264.7 macrophages

1998 • 73 citations

Gβ Subunit Interacts with a Peptide Encoding Region 956-982 of Adenylyl Cyclase 2

1996 • 50 citations

An increase in intracellular cyclic AMP modulates nitric oxide production in IFN-gamma-treated macrophages.

1997 • 45 citations

Effects of Lysophosphatidic Acid, a Novel Lipid Mediator, on Cytosolic Ca ²⁺ and Contractility in Cultured Rat Mesangial Cells

1995 • 43 citations

Activation of protein kinase C by lysophosphatidic acid: dependence on composition of phospholipid vesicles

1996 • 43 citations

Characterization of sphingosine 1-phosphate-induced actions and its signaling pathways in rat hepatocytes

1997 • 42 citations

Modulation of ζ‐Protein Kinase C by Cyclic AMP in PC12 Cells Occurs Through Phosphorylation by Protein Kinase A

1996 • 41 citations

Colchicine and cytochalasin B enhance cyclic AMP accumulation via postreceptor actions.

1995 • 27 citations

The effect of active serum albumin on PC12 cells: II. Intracellular Ca2+ transients and their role in neurite retraction

1992 • 26 citations

Enhancement of macrophage adenylate cyclase by microtubule disrupting drugs

1978 • 23 citations

Lysophosphatidic acid regulation of cyclic AMP accumulation in cultured human airway smooth muscle cells.

1995 • 22 citations

Lysophosphatidic acid mimics serum‐induced sensitization of cyclic AMP accumulation

1993 • 19 citations

Involvement of protein kinase C in the UTP‐mediated potentiation of cyclic AMP accumulation in mouse J774 macrophages

1997 • 18 citations

Stimulation of high-affinity GTPase activity and cholera toxin-catalysed [32P]ADP-ribosylation of Gi by lysophosphatidic acid (LPA) in wild-type and α2C10 adrenoceptor-transfected Rat 1 fibroblasts

1994 • 14 citations

The adhesiveness of monocytic U937 cells is stimulated by pro-inflammatory agents and inhibited by adenosine 3':5'-cyclic monophosphate

1990 • 6 citations

Evidence for a role of G protein βγ subunits in the enhancement of cAMP accumulation and DNA synthesis by adenosine in human cells

1997 • 4 citations

Modulation of cyclic AMP accumulation in glial cells by exogenous phospholipase C

1996 • 2 citations