The inhibition of protein prenyltransferases by oxygenated metabolites of limonene and perillyl alcohol

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

1990 • 815 citations

Benzodiazepine Peptidomimetics: Potent Inhibitors of Ras Farnesylation In Animal Cells

1993 • 631 citations

Selective Inhibition of ras -Dependent Transformation by a Farnesyltransferase Inhibitor

1993 • 578 citations

Ras C-terminal processing enzymes—New drug targets?

1991 • 461 citations

PROTEIN PRENYLATION: GENES, ENZYMES, TARGETS, AND FUNCTIONS

1992 • 380 citations

Selective inhibition of isoprenylation of 21-26-kDa proteins by the anticarcinogen d-limonene and its metabolites.

1991 • 267 citations

Identification of Ras farnesyltransferase inhibitors by microbial screening.

1993 • 259 citations

Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo.

1993 • 257 citations

Steady-state kinetic mechanism of ras farnesyl:protein transferase

1992 • 242 citations

A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity.

1991 • 221 citations

Limonene-induced regression of mammary carcinomas.

1992 • 210 citations

Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42.

1990 • 204 citations

Mammary carcinoma regression induced by perillyl alcohol, a hydroxylated analog of limonene

1994 • 190 citations

Nonfarnesylated tetrapeptide inhibitors of protein farnesyltransferase

1991 • 183 citations

Structure-activity relationships among monoterpene inhibitors of protein isoprenylation and cell proliferation

1994 • 182 citations

Inhibition of DMBA-induced mammary cancer by the monoterpene d-limonene

1984 • 167 citations

Mammalian protein geranylgeranyltransferase. Subunit composition and metal requirements.

1992 • 157 citations

Protein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene product.

1991 • 148 citations

The prevention of nitrosomethylurea-induced mammary tumors by d-limonene and orange oil

1989 • 145 citations

Increased mannose 6-phosphate/insulin-like growth factor II receptor and transforming growth factor beta 1 levels during monoterpene-induced regression of mammary tumors.

1993 • 114 citations

Identification of metabolites of the antitumor agentd-limonene capable of inhibiting protein isoprenylation and cell growth

1992 • 114 citations

Human metabolism of the experimental cancer therapeutic agentd-limonene

1994 • 108 citations

Purification and Characterization of Human H-ras Proteins Expressed in Escherichia coli

1985 • 101 citations

Purification of a mammalian protein geranylgeranyltransferase. Formation and catalytic properties of an enzyme-geranylgeranyl pyrophosphate complex.

1993 • 91 citations

Regression of Rat Primary Mammary Tumors Following Dietary <italic>d</italic>-Limonene<xref ref-type="fn" rid="FN2">2</xref>

1986 • 89 citations

Inhibition of ubiquinone and cholesterol synthesis by the monoterpene perillyl alcohol

1994 • 64 citations

Purified yeast protein farnesyltransferase is structurally and functionally similar to its mammalian counterpart

1993 • 55 citations

Purification and characterization of human H-ras proteins expressed in Escherichia coli.

1985 • 53 citations

Limonene trial in cancer

1993 • 37 citations