A pathogenetic role for the thymoma in myasthenia gravis. Autosensitization of IL-4- producing T cell clones recognizing extracellular acetylcholine receptor epitopes presented by minority class II isotypes.

Myasthenia Gravis

1997 • 2,469 citations

The Spectrum of Diseases Associated With Thymoma

1974 • 351 citations

Specificities of antibodies to acetylcholine receptors in sera from myasthenia gravis patients measured by monoclonal antibodies.

1982 • 342 citations

Purification and characterization of class II histocompatibility antigens from a homozygous human B cell line.

1987 • 222 citations

Patients with myasthenia gravis and thymoma have in their sera IgG autoantibodies against titin

1990 • 179 citations

Interleukin-4 mediates CDS induction on human CD4+ T-cell clones

1988 • 163 citations

Mapping the Main Immunogenic Region and Toxin-Binding Site of the Nicotinic Acetylcholine Receptor

1987 • 161 citations

Myasthenic thymus and thymoma are selectively enriched in acetylcholine receptor–reactive T cells

1990 • 153 citations

Pathogenesis of myasthenia gravis

1997 • 132 citations

Pathogenesis of myasthenia gravis. Acetylcholine receptor-related antigenic determinants in tumor-free thymuses and thymic epithelial tumors.

1988 • 129 citations

Myasthenic and nonmyasthenic thymoma. An expansion of a minor cortical epithelial cell subset?

1987 • 117 citations

Thymic B lymphocyte clones from patients with myasthenia gravis secrete monoclonal striational autoantibodies reacting with myosin, alpha actinin, or actin.

1986 • 107 citations

Human T-helper lymphocytes in myasthenia gravis recognize the nicotinic receptor alpha subunit.

1987 • 100 citations

Myasthenia gravis

1993 • 100 citations

Characterization of the human T cell receptor α‐chain repertoire and demonstration of a genetic influence on Vα usage

1993 • 84 citations

Direct demonstration of an HLA-DR allotypic determinant on the low molecular weight (beta) subunit using a mouse monoclonal antibody specific for DR3

1982 • 83 citations

Sequence analysis of the human ?? T-cell receptor CDR3 region

1995 • 82 citations

Antibody to acetylcholine receptor in myasthenia gravis

1984 • 80 citations

Properties of a panel of monoclonal antibodies which react with the human T cell antigen receptor on the leukemic line HPB-ALL and a subset of normal peripheral blood T lymphocytes.

1986 • 80 citations

Suppression of Experimental Autoimmune Myasthenia Gravis by Epitope-Specific Neonatal Tolerance to Synthetic Region α146-162 of Acetylcholine Receptor

1993 • 78 citations

Antibody Heterogeneity and Specificity in Myasthenia Gravis^a

1987 • 78 citations

Specific tolerance to an acetylcholine receptor epitope induced in vitro in myasthenia gravis CD4+ lymphocytes by soluble major histocompatibility complex class II-peptide complexes.

1994 • 77 citations

Primary structure of the human muscle acetylcholine receptor

1993 • 73 citations

The main immunogenic region (MIR) of the nicotinic acetylcholine receptor and the anti-MIR antibodies

1991 • 68 citations

Expression of neurofilaments and of a titin epitope in thymic epithelial tumors. Implications for the pathogenesis of myasthenia gravis.

1996 • 66 citations

Peptide-selected T cell lines from myasthenia gravis patients and controls recognize epitopes that are not processed from whole acetylcholine receptor.

1995 • 61 citations

Molecular evidence for the expression of nicotinic acetylcholine receptor alpha-chain in mouse thymus.

1992 • 60 citations

Autoimmune T cells in myasthenia gravis: heterogeneity and potential for specific immunotargeting

1996 • 56 citations

Rabbit antiserum to a citric acid extract of human skeletal muscle staining thymomas from myasthenia gravis patients

1984 • 55 citations

Antigen presentation by thymoma epithelial cells from myasthenia gravis patients to potentially pathogenic T cells

1995 • 54 citations

Constitutive and induced expression of the individual HLA-DR beta and alpha chain loci in different cell types

1988 • 53 citations

Stable functional expression of the adult subtype of human muscle acetylcholine receptor following transfection of the human rhabdomyosarcoma cell line TE671 with cDNA encoding the ε subunit

1996 • 49 citations

Activated T cells and monocytes have characteristic patterns of class II antigen expression.

1988 • 48 citations

Myasthenia Gravis: Immunohistological heterogeneity in microenvironmental organization of hyperplastic and neoplastic thymuses suggesting different mechanisms of tolerance breakdown

1986 • 44 citations

Thymomatous epithelial cells and skeletal muscle share a common epitope defined by a monoclonal antibody.

1987 • 43 citations

Accumulation of Immature CD3-CD4+CD8- Single-Positive Cells That Lack CD69 in Epithelial Cell Tumors of the Human Thymus

1995 • 41 citations

Neoplastic epithelial cells express α‐subunit of muscle nicotinic acetylcholine receptor in thymomas from patients with myasthenia gravis

1991 • 36 citations

Autoimmunity to ion-channels and other proteins in paraneoplastic disorders

1996 • 34 citations

Approaches for Studying the Pathogenic T Cells in Autoimmune Patientsa

1993 • 33 citations

Nicotinic Acetylcholine Receptor mRNAs in Myasthenic Thymuses: Association with Intrathymic Pathogenesis of Myasthenia Gravis

1993 • 30 citations

Bimodal distribution of Vβ2⁺CD4⁺ T cells in human peripheral blood

1994 • 30 citations

Epitopes expressed in myasthenia gravis (MG) thymomas are not recognized by patients' T cells or autoantibodies

1998 • 26 citations

Stimulation of human T cells by sparse antigens captured on immunomagnetic particles

1992 • 23 citations

Human muscle acetylcholine receptor: cloning and expression in Escherichia coli of cDNA for the α-subunit

1989 • 22 citations

Thymus, Thymoma, and Specific T Cells in Myasthenia Gravisa

1998 • 20 citations

The myelin basic protein‐specific T cell repertoire in (transgenic) Lewis rat/SCID mouse chimeras: preferential Vβ8.2 T cell receptor usage depends on an intact Lewis thymic microenvironment

1996 • 18 citations

Diverse patterns of unresponsiveness in an acetylcholine receptor-specific T-cell clone from a myasthenia gravis patient after engaging the T-cell receptor with three different ligands

1998 • 11 citations

Epithelial tumors of the thymus : pathology, biology, treatment

1997 • 10 citations

Antibody to acetylcholine receptor in myasthenia gravis : production by lymphocytes from thymus or thymoma

1985 • 2 citations