Current status of artificial oxygen carriers

Immediate versus Delayed Fluid Resuscitation for Hypotensive Patients with Penetrating Torso Injuries

1994 • 2,116 citations

S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control

1996 • 1,604 citations

Practice Guidelines for blood component therapy: A report by the American Society of Anesthesiologists Task Force on Blood Component Therapy.

1996 • 897 citations

Practice Guidelines for Blood Component Therapy

1996 • 730 citations

Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin

1998 • 427 citations

The first randomized trial of human polymerized hemoglobin as a blood substitute in acute trauma and emergent surgery

1998 • 334 citations

A human recombinant haemoglobin designed for use as a blood substitute

1992 • 310 citations

Cardiovascular and Coronary Physiology of Acute Isovolemic Hemodilution

1994 • 254 citations

Transfusing red blood cells stored in citrate phosphate dextrose adenine-1 for 28 days fails to improve tissue oxygenation in rats

1997 • 235 citations

A role for endothelin and nitric oxide in the pressor response to diaspirin cross-linked hemoglobin.

1993 • 226 citations

Controlled Safety Study of a Hemoglobin-Based Oxygen Carrier, DCLHb, in Acute Ischemic Stroke

1999 • 226 citations

Effect of progressive haemodilution with hydroxyethyl starch, gelatin and albumin on blood coagulation

1997 • 179 citations

Perflubron Emulsion Delays Blood Transfusions in Orthopedic Surgery

1999 • 178 citations

Phase I study of the safety and pharmacologic effects of diaspirin cross-linked hemoglobin solution

1996 • 139 citations

Effects of a Hemoglobin-Based Oxygen Carrier (HBOC-201) on Hemodynamics and Oxygen Transport in Patients Undergoing Preoperative Hemodilution for Elective Abdominal Aortic Surgery

1996 • 130 citations

Hemodynamic effects and oxygen transport properties of a new blood substitute in a model of massive blood replacement

1990 • 127 citations

Clinical Development of Human Polymerized Hemoglobin as a Blood Substitute

1996 • 123 citations

Initial evaluation of diaspirin cross-linked hemoglobin (DCLHb[trademark symbol]) as a vasopressor in critically ill patients

1997 • 119 citations

Bovine haemoglobin is more potent than autologous red blood cells in restoring muscular tissue oxygenation after profound isovolaemic haemodilution in dogs

1996 • 118 citations

Role of endothelin in the cardiovascular effects of diaspirin crosslinked and stroma reduced hemoglobin

1996 • 114 citations

Clinical Utility of Human Polymerized Hemoglobin as a Blood Substitute after Acute Trauma and Urgent Surgery

1997 • 111 citations

Role of adrenergic mechanisms in the pressor effect of diaspirin cross-linked hemoglobin.

1994 • 97 citations

The Effects of Increased Doses of Bovine Hemoglobin on Hemodynamics and Oxygen Transport in Patients Undergoing Preoperative Hemodilution for Elective Abdominal Aortic Surgery

1998 • 92 citations

Recombinant Human Hemoglobin Does Not Affect Renal Function in Humans

1997 • 89 citations

Effects of hyperoxic ventilation on hemodilution‐induced changes in anesthetized dogs

1998 • 89 citations

Effect of hemoglobin- and Perflubron-based oxygen carriers on common clinical laboratory tests

1997 • 87 citations

Current Status of Injectable Oxygen Carriers

1994 • 80 citations

Reduction of myocardial ischemia during percutaneous transluminal coronary angioplasty with oxygenated Fluosol®

1990 • 79 citations

Hemodilution and intravenous perflubron emulsion as an alternative to blood transfusion: effects on tissue oxygenation during profound hemodilution in anesthetized dogs

1998 • 79 citations

Overview of Progress in the Fluorocarbon Approach toin vivoOxygen Delivery

1992 • 77 citations

Effects of 6% Hydroxyethyl Starch and 3% Modified Fluid Gelatin on Intravascular Volume and Coagulation During Intraoperative Hemodilution

1995 • 77 citations

Use of Recombinant Hemoglobin Solution in Reversing Lethal Hemorrhagic Hypovolemic Oxygen Debt Shock

1997 • 76 citations

A Pilot Study of the Effects of a Perflubron Emulsion, AF 0104, on Mixed Venous Oxygen Tension in Anesthetized Surgical Patients

1996 • 73 citations

Bovine hemoglobin increases skeletal muscle oxygenation during 95% artificial arterial stenosis

1997 • 71 citations

Thrombelastogram reveals hypercoagulability after administration of gelatin solution

1999 • 68 citations

Review of physiologic mechanisms in response to anemia

1997 • 67 citations

Bovine haemoglobin-based oxygen carrier for patients undergoing haemodilution before liver resection

1998 • 60 citations

Oxygen Delivery Augmentation by Low-Dose Perfluorochemical Emulsion During Profound Normovolemic Hemodilution

1994 • 47 citations

IV Perflubron emulsion versus autologous transfusion in severe normovolemic anemia: effects on left ventricular perfusion and function

1997 • 47 citations

Resuscitation from Hemorrhagic Shock with Diaspirin Cross-linked Hemoglobin, Blood, or Hetastarch

1997 • 47 citations

DOSE-DEPENDENT EFFECT OF DIASPIRIN CROSS-LINKED HEMOGLOBIN ON REGIONAL BLOOD CIRCULATION OF SEVERELY HEMORRHAGED RATS

1998 • 46 citations

Effect of supplemental perfluorocarbon administration on hypotensive resuscitation of severe uncontrolled hemorrhage

1995 • 44 citations

Recombinant Human Hemoglobin Does Not Affect Renal Function in Humans

1998 • 43 citations

In vivo distribution and elimination of hemoglobin modified by intramolecular cross-linking with 2-nor-2-formylpyridoxal 5'-phosphate.

1989 • 43 citations

Diaspirin cross-linked hemoglobin: tissue distribution and long-term excretion after exchange transfusion.

1994 • 43 citations

Präoperative Hämodilution mit bovinem Hämoglobin

1997 • 37 citations

Tissue oxygenation with graded dissolved oxygen delivery during cardiopulmonary bypass

1995 • 37 citations

Supporting Tissue Oxygenation During Acute Surgical Bleeding Using A Perfluorochemical-Based Oxygen Carrier

1996 • 37 citations

Metabolic and functional effects of perfluorocarbon distal perfusion during coronary angioplasty

1990 • 35 citations

Cellular Responses to Surgical Trauma, Hemorrhage, and Resuscitation with Diaspirin Cross-Linked Hemoglobin in Rats

1997 • 32 citations

Effect of the Hemoglobin-Based Oxygen Carrier HBOC-201 on Laboratory Instrumentation: Cobas Integra, Chiron Blood Gas Analyzer 840, Sysmex™SE-9000 and BCT

1999 • 30 citations

Akute Auswirkungen eines kompletten Blutaustauschs mit ultragereinigter Hämoglobinlösung oder Hydroxyäthylstärke auf Leber und Niere im Tiermodell

1996 • 30 citations

The Effects of Cross-Linked Hemoglobin on Regional Vascular Conductance in Dogs

1997 • 29 citations

Selective Aortic Arch Perfusion During Cardiac Arrest: Enhanced Resuscitation Using Oxygenated Perflubron Emulsion, With and Without Aortic Arch Epinephrine

1997 • 26 citations

Update on Perfluorocarbon-Based Oxygen Delivery Systems

1998 • 26 citations

Absence of Immunogenicity of Diaspirin Cross-Linked Hemoglobin in Humans

1998 • 17 citations

Effect of diaspirin cross-linked hemoglobin on normal and postischemic microcirculation of the rat pancreas

1999 • 15 citations

A217 THE USE OF DIASPIRIN CROSSLINKED HEMOGLOBIN (DCLHB) AS AN ALTERNATIVE TRANSFUSION IN CARDIAC SURGERY PATIENTS FOLLOWING CARDIOPULMONARY BYPASS

1997 • 14 citations

Effects of Perflubron Emulsion and 100% Oxygen Breathing on Local Tissue PO2 in Brain Cortex of Unanaesthetized Rabbits

1997 • 9 citations

The effects of diaspirin‐crosslinked hemoglobin on the assessment of immunohematology profiles

1997 • 9 citations