Review of physiologic mechanisms in response to anemia

A Trial of Goal-Oriented Hemodynamic Therapy in Critically Ill Patients

1995 • 1,526 citations

The number and distribution of capillaries in muscles with calculations of the oxygen pressure head necessary for supplying the tissue

1919 • 1,388 citations

Septic Shock in Humans

1990 • 1,170 citations

The effect of organic phosphates from the human erythrocyte on the allosteric properties of hemoglobin

1967 • 1,139 citations

Cerebral vasospasm following aneurysmal subarachnoid hemorrhage.

1985 • 1,106 citations

Hemoglobin: Molecular, Genetic and Clinical Aspects.

1986 • 1,005 citations

Effect of anaemia and cardiovascular disease on surgical mortality and morbidity

1996 • 992 citations

Effect of organic and inorganic phosphates on the oxygen equilibrium of human erythrocytes

1967 • 961 citations

A Randomized Clinical Trial of the Effect of Deliberate Perioperative Increase of Oxygen Delivery on Mortality in High-Risk Surgical Patients

1993 • 949 citations

Practice Guidelines for blood component therapy: A report by the American Society of Anesthesiologists Task Force on Blood Component Therapy.

1996 • 897 citations

Effect of Stored-Blood Transfusion on Oxygen Delivery in Patients With Sepsis

1993 • 807 citations

[Multiple organ failure syndrome].

1988 • 795 citations

Users' Guides to the Medical Literature

1994 • 776 citations

Physiology of the heart

1977 • 769 citations

Consensus conference. Perioperative red blood cell transfusion

1988 • 621 citations

End-systolic pressure/volume ratio: A new index of ventricular contractility

1977 • 602 citations

Ueber einen in biologischer Beziehung wichtigen Einfluss, den die Kohlensäurespannung des Blutes auf dessen Sauerstoffbindung übt¹

1904 • 592 citations

Reciprocal binding of oxygen and diphosphoglycerate by human hemoglobin.

1968 • 513 citations

Guidelines for reading literature reviews.

1988 • 499 citations

The supply of oxygen to the tissues and the regulation of the capillary circulation

1919 • 495 citations

The ventricular pressure-volume diagram revisited.

1978 • 479 citations

Systematic Reviews: Checklists for review articles

1994 • 478 citations

Clinical vasospasm after subarachnoid hemorrhage: response to hypervolemic hemodilution and arterial hypertension.

1987 • 444 citations

Practice Guidelines, a New Reality in Medicine

1992 • 416 citations

Influence of reduced red cell deformability on regional blood flow

1987 • 392 citations

Critical level of oxygen delivery in anesthetized man

1983 • 380 citations

The Effect of Fluid Loading, Blood Transfusion, and Catecholamine Infusion on Oxygen Delivery and Consumption in Patients with Sepsis^1,2

1986 • 367 citations

Prudent Strategies for Elective Red Blood Cell Transfusion

1992 • 363 citations

The respiratory function of the blood

1914 • 359 citations

Maximizing oxygen delivery in critically ill patients

1996 • 357 citations

Does transfusion practice affect mortality in critically ill patients? Transfusion Requirements in Critical Care (TRICC) Investigators and the Canadian Critical Care Trials Group.

1997 • 352 citations

Pathological supply dependence of systemic and intestinal O2 uptake during endotoxemia

1988 • 338 citations

Oxygen Transport in Man

1972 • 315 citations

Effect of positive inotropic agents on the relation between oxygen consumption and systolic pressure volume area in canine left ventricle.

1983 • 310 citations

Identification of the critical oxygen delivery for anaerobic metabolism in critically ill septic and nonseptic humans

1993 • 280 citations

Effects of hematocrit variations on regional hemodynamics and oxygen transport in the dog

1980 • 272 citations

Cardiovascular and Coronary Physiology of Acute Isovolemic Hemodilution

1994 • 254 citations

The Hemodynamic Response to Chronic Anemia

1969 • 252 citations

Ventricular systolic pressure-volume area as predictor of cardiac oxygen consumption

1981 • 231 citations

Effects of polycythemia and anemia on cardiac output and other circulatory factors

1959 • 227 citations

THE CARDIAC OUTPUT IN PATIENTS WITH CHRONIC ANEMIA AS MEASURED BY THE TECHNIQUE OF RIGHT ATRIAL CATHETERIZATION 1

1945 • 211 citations

Changes in Physical Properties of Stored Erthrocytes

1969 • 202 citations

Oxygen Consumption Is Independent of Changes in Oxygen Delivery in Severe Adult Respiratory Distress Syndrome

1991 • 190 citations

Present State of Intentional Hemodilution

1986 • 177 citations

Oxygen Consumption and Cardiovascular Function in Children During Profound Intraoperative Normovolemic Hemodilution

1995 • 176 citations

Alteration of Deformability of the Erythrocyte Membrane in Stored Blood

1969 • 176 citations

Cardiovascular and metabolic response to red blood cell transfusion in critically ill volume-resuscitated nonsurgical patients

1990 • 173 citations

Effects of blood transfusion on oxygen transport variables in severe sepsis

1993 • 156 citations

Hemodilution Tolerance in Patients with Coronary Artery Disease Who Are Receiving Chronic beta-Adrenergic Blocker Therapy

1996 • 146 citations

The physiologic reserve in oxygen carrying capacity: studies in experimental hemodilution

1986 • 145 citations

Systemic and intestinal limits of O2 extraction in the dog

1987 • 143 citations

Red-Cell 2,3-Diphosphoglycerate Levels in Subjects with Chronic Hypoxemia

1969 • 143 citations

Effect of a reduction in blood viscosity on maximal myocardial oxygen delivery distal to a moderate coronary stenosis.

1986 • 142 citations

The effect of hemodilution on regional myocardial function in the presence of coronary stenosis

1977 • 135 citations

Acute Normovolemic Hemodilution

1972 • 133 citations

Limits of cardiac compensation in anemic baboons.

1988 • 133 citations

Effect of hematocrit variations on coronary hemodynamics and oxygen utilization

1977 • 132 citations

Blood viscosity and cardiac output in acute experimental anemia

1975 • 130 citations

Effect of blood transfusion on oxygen consumption in pediatric septic shock

1990 • 122 citations

Acceptable hematocrit levels in surgical patients

1987 • 119 citations

Acute Hernodilution

1974 • 112 citations

The adequacy of myocardial oxygen delivery in acute normovolemic anemia.

1974 • 109 citations

Hemodynamic Effects of Chronic Severe Anemia

1963 • 108 citations

Relationship of cerebral blood flow to cardiac output, mean arterial pressure, blood volume, and alpha and beta blockade in cats

1980 • 105 citations

Anemia as a stimulus to aortic and carotid chemoreceptors in the cat

1978 • 104 citations

Red Blood Cell Deformability in Human and Experimental Sepsis

1988 • 104 citations

Failure of Red Blood Cell Transfusion to Increase Oxygen Transport or Mixed Venous PO2 in Injured Patients

1982 • 103 citations

Custom-tailored hemodilution with albumin and crystalloids in acute ischemic stroke.

1992 • 103 citations

Role of the Autonomic Nervous System in the Circulatory Response to Acutely Induced Anemia in Unanesthetized Dogs *

1964 • 103 citations

The rate of oxygen release and its effect on capillary O2 tension: A mathematical analysis

1986 • 101 citations

Exercise with Anemia

1971 • 101 citations

Effects of blood viscosity on hemodynamic responses in acute normovolemic anemia

1969 • 100 citations

Oxygen Delivery and Uptake by Peripheral Tissues: Physiology and Pathophysiology

1989 • 99 citations

Decrease in left ventricular contractility after tumor necrosis factor-alpha infusion in dogs

1994 • 98 citations

Regional blood flow during dextran-induced normovolemic hemodilution in the dog

1967 • 98 citations

Blood transfusion and oxygen consumption in surgical sepsis

1991 • 96 citations

Mechanism of cerebral blood flow augmentation by hemodilution in rabbits.

1992 • 93 citations

Increased concentrations of plasma lactate predict pathologic dependence of oxygen consumption on oxygen delivery in patients with adult respiratory distress syndrome

1990 • 90 citations

The Oxygen Dissociation Curve in Anemia Of Various Types1

1954 • 88 citations

Acute isovolemic hemodilution and blood transfusion. Effects on regional function and metabolism in myocardium with compromised coronary blood flow.

1993 • 88 citations

The Respiratory Function of the Blood. Part 1. Lessons from High Altitudes.

1925 • 86 citations

Coronary and cardiovascular dynamics and oxygen availability during acute normovolemic anemia.

1976 • 86 citations

Acute Dilutional Anemia and Critical Left Anterior Descending Coronary Artery Stenosis Impairs End Organ Oxygen Delivery

1996 • 85 citations

THE OXYHEMOGLOBIN DISSOCIATION CURVE IN ANEMIA

1960 • 84 citations

Effect of hemodilution on oxygen transport in arteriolar networks of hamster striated muscle

1988 • 82 citations

Dependence of oxygen consumption on oxygen delivery in children with hyperdynamic septic shock and how oxygen extraction

1990 • 81 citations

Oxygen free radicals

1991 • 80 citations

The Effect of Acute Normovolemic Hemodilution (ANH) on Myocardial Contractility in Anesthetized Dogs

1996 • 78 citations

Red cell deformability is an early indicator of infection.

1991 • 77 citations

Subendocardial ischemia provoked by tachycardia in conscious dogs with coronary stenosis

1975 • 76 citations

Effect of heart rate on coronary blood flow distribution in dogs

1973 • 75 citations

Graded coronary stenosis and coronary flow during acute normovolemic anemia

1978 • 72 citations

Effect of red cell transfusion on oxygen consumption following fluid resuscitation in septic shock.

1990 • 71 citations

Perioperative haemotherapy: I. Indications for blood component transfusion

1992 • 71 citations

Experimental Hypervolemic Hemodilution: Physiological Correlations of Cortical Blood Flow, Cardiac Output, and Intracranial Pressure with Fresh Blood Viscosity and Plasma Volume

1984 • 70 citations

Effect of increased oxygen affinity and anemia on cardiac output and its distribution

1982 • 70 citations

Hemodilution ‐ possibilities and safety aspects

1988 • 69 citations

Adjusted hypervolemic hemodilution in acute ischemic stroke.

1990 • 69 citations

Oxygen transport in adult respiratory distress syndrome and other acute circulatory problems

1991 • 67 citations

Importance of Monitoring the Circulating Blood Volume in Patients with Cerebral Vasospasm after Subarachnoid Hemorrhage

1981 • 67 citations

The basis of defective oxygen delivery from stored blood.

1970 • 62 citations

Comparison of crystalloids and colloids for hemodilution in a model of focal cerebral ischemia

1990 • 62 citations

Determination of red blood cell oxygenation in vivo by dual video densitometric image analysis

1990 • 61 citations

Neurological deterioration under isovolemic hemodilution with hydroxyethyl starch in acute cerebral ischemia.

1991 • 60 citations

Marked Hemodilution Increases Neurologic Injury After Focal Cerebral Ischemia in Rabbits

1996 • 60 citations

Evaluation of long-term outcome and safety after hemodilution therapy in acute ischemic stroke.

1992 • 59 citations

Reevaluation of current transfusion practices in patients in surgical intensive care units

1992 • 59 citations

Massive Blood Transfusion

1976 • 59 citations

Intraoperative normovolemic hemodilution

1981 • 58 citations

Increased Cardiac Output and Oxygen Transport After Intraoperative Isovolemic Hemodilution

1980 • 58 citations

Focal Cerebral Ischemia in Rats: Effect of Hemodilution with α-α Cross-Linked Hemoglobin on CBF

1992 • 58 citations

Hemodynamic oxygen transport and 2,3-diphosphoglycerate changes after transfusion of patients in acute respiratory failure

1986 • 58 citations

Hemodilution increases cerebral blood flow in acute ischemic stroke.

1989 • 56 citations

Effects of Isovolemic Hemodilution on Hemodynamics, Cerebral Perfusion, and Cerebral Vascular Reactivity

1996 • 52 citations

Ventricular performance in acute normovolemic anemia and effects of beta blockade

1966 • 51 citations

Hemodynamics Following Normovolemic Hemodilution in Elderly Patients

1981 • 50 citations

Scanning Electron Microscope Studies of Red Cell Morphology

1972 • 50 citations

Coronary blood flow and myocardial metabolism in acute experimental anaemia

1972 • 49 citations

Multicenter Trial of Hemodilution in Acute Ischemic Stroke

1987 • 49 citations

Oxygen Transport In The Critically Ill

1987 • 48 citations

Effects of Acute Normovolemic Hemodilution on Splanchnic Oxygenation and on Hepatic Histology and Metabolism in Anesthetized Pigs

1991 • 47 citations

The Respiratory Function of Blood

1972 • 47 citations

Acute effects of isovolemic hemodilution with crystalloids in a canine model of focal cerebral ischemia.

1989 • 46 citations

RETRACTED: Acute preoperative hemodilution in cardiac surgery: Volume replacement with a hypertonic saline-hydroxyethyl starch solution

1991 • 46 citations

Does colloid‐induced plasma hyperviscosity in haemodilution jeopardize perfusion and oxygenation of vital organs?

1995 • 44 citations

Hemodynamic Effects of Blood Transfusion in Chronic Anemia

1964 • 42 citations

Reduced RBC versus plasma microvascular flow due to endotoxin.

1986 • 41 citations

Effect of Preoperative Normovolemic Hemodilution on Left Ventricular Segmental Wall Motion During Abdominal Aortic Surgery

1992 • 41 citations

Effects of hemodilution on skin microcirculation

1988 • 40 citations

Circulation of Red Blood Cells Having High Levels of 2,3-Bisphosphoglycerate Protects Rat Brain From Ischemic Metabolic Changes During Hemodilution

1995 • 40 citations

Splanchnic Hemodynamics and Oxygen Supply During Acute Normovolemic Hemodilution Alone and With Isoflurane-Induced Hypotension in the Anesthetized Pig

1992 • 40 citations

Pathologic Dependence of Oxygen Consumption on Oxygen Delivery in Acute Respiratory Failure Secondary to AIDS-Related Pneumocystis carinii Pneumonia

1990 • 39 citations

The role of pentoxifylline in endotoxin-induced alterations of red cell deformability and whole blood viscosity in the neonate

1991 • 38 citations

Comparative study of limited intentional normovolaemic haemodilution in patients with left main coronary artery stenosis

1995 • 38 citations

Myocardial Oxygen Consumption and Segmental Shortening during Selective Coronary Hemodilution in Dogs

1988 • 37 citations

Maximum myocardial oxygen transport during anemia and polycythemia in dogs

1987 • 37 citations

Extreme Hemodilution in the Harrington Procedure

2015 • 36 citations

Tissue Oxygen Delivery

1990 • 36 citations

Coronary hemodynamics and oxygen utilization after hematocrit variations in hemorrhage

1980 • 35 citations

Myocardial Blood Flow and Oxygen Consumption during Isovolemic Hemodilution Alone and in Combination with Adenosine-Induced Controlled Hypotension

1988 • 34 citations

Microcirculation in striated muscle after acute reduction in systemic hematocrit

1989 • 34 citations

Hemodilution Induces Stable Changes in Global Cardiovascular and Regional Myocardial Function

1993 • 34 citations

SOME EFFECTS OF SEVERE CHRONIC ANAEMIA ON THE CIRCULATORY SYSTEM<sup>1</sup>

1956 • 34 citations

Optimal Timing of Hemodilution for Brain Protection in a Canine Model of Focal Cerebral Ischemia

1996 • 34 citations

The preservation of renal function by isovolemic hemodilution during aortic operations

1993 • 33 citations

Cellular Oxygen Utilization During Multiple Organ Failure

1989 • 32 citations

Cardiovascular Function in Children with Severe Anemia

1969 • 30 citations

Tissue perfusion during normovolemic hemodilution investigated by a hydraulic model of the cardiovascular system.

1987 • 30 citations

The P50 is reduced in critically ill patients

1991 • 28 citations

Effect of isovolemic anemia on ventricular performance at rest and during exercise.

1974 • 27 citations

Does Hemoglobin Concentration Affect Perioperative Myocardial Lactate Flux in Patients Undergoing Coronary Artery Bypass Surgery?

1995 • 27 citations

The Effect of Hemodilution on Experimental Myocardial Infarct Size

1980 • 22 citations

Effects of hemodilution on gastric and intestinal oxygenation

1989 • 20 citations

Transfusion therapy in trauma: a review of the principles and techniques used in the MIEMS program.

1979 • 20 citations

Normovolemic Hemodilution and Lumbar Epidural Anesthesia

1989 • 19 citations

Preoperative Hemoglobin Requirements

1990 • 19 citations

Circulatory effects of acute normovolaemic haemodilution in rats with healed myocardial infarction

1989 • 18 citations

Effects of hypothermia and hemodilution on oxygen metabolism and hemodynamics in patients recovering from coronary artery bypass operations

1989 • 18 citations

Optimal hematocrit for canine gastric oxygenation

1989 • 18 citations

Rejuvenation of Erythrocytes Preserved With AS-1 and AS-3

1991 • 16 citations

Oxygen dissociation after transfusion of blood stored in ACD or CPD solution

1975 • 14 citations

The effect of intentional hemodilution on P50.

1988 • 12 citations

Peripheral vascular responses during acute anemia

1981 • 11 citations

Oxygen kinetics: Pitfalls in clinical research revisited

1990 • 11 citations

THE ROLE OF A HUMORAL MECHANISM IN THE CARDIOVASCULAR ADJUSTMENTS OVER A PROLONGED PERIOD FOLLOWING THE PRODUCTION OF ACUTE EXCHANGE ANAEMIA

1963 • 10 citations

Optimal contractility and minimal oxygen consumption for constant external work of heart

1988 • 10 citations

Restoration of blood 2,3-diphosphoglycerate levels in multi-transfused patients: effect of organic and inorganic phosphate.

1984 • 9 citations

Isovolemic Hemodilution Normalizes the Prolonged Passage of Red Cells and Plasma through Cerebral Microvessels in the Partially Ischemic Forebrain of Rats

1996 • 9 citations

Effect of acute posthaemorrhagic anaemia on the level of 2,3-diphosphoglycerate (2,3-DPG) in the erythrocytes of sheep.

1980 • 5 citations