Effect of von Willebrand Factor and Its Proteolytic Fragments on Kinetics of Interaction between the Light and Heavy Chains of Human Factor VIII

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Immobilization of proteins to a carboxymethyldextran-modified gold surface for biospecific interaction analysis in surface plasmon resonance sensors

1991 • 1,263 citations

Structure of human factor VIII

1984 • 898 citations

The role of phospholipid and factor VIIIa in the activation of bovine factor X.

1981 • 590 citations

Determination of Rate and Equilibrium Binding Constants for Macromolecular Interactions Using Surface Plasmon Resonance: Use of Nonlinear Least Squares Analysis Methods

1993 • 540 citations

Amino acid sequence of human von Willebrand factor

1986 • 486 citations

A major factor VIII binding domain resides within the amino-terminal 272 amino acid residues of von Willebrand factor.

1987 • 263 citations

Identification of disulfide-bridged substructures within human von Willebrand factor

1987 • 262 citations

Association of the factor VIII light chain with von Willebrand factor.

1988 • 223 citations

Human factor VIIIa subunit structure. Reconstruction of factor VIIIa from the isolated A1/A3-C1-C2 dimer and A2 subunit

1991 • 217 citations

The Acidic Region of the Factor VIII Light Chain and the C2 Domain Together Form the High Affinity Binding Site for von Willebrand Factor

1997 • 196 citations

A role for the C2 domain of factor VIII in binding to von Willebrand factor

1994 • 192 citations

Slowed Release of Thrombin-cleaved Factor VIII from von Willebrand Factor by a Monoclonal and a Human Antibody Is a Novel Mechanism for Factor VIII Inhibition

1996 • 175 citations

The size of human factor VIII heterodimers and the effects produced by thrombin

1986 • 161 citations

The role of von Willebrand factor multimers and propeptide cleavage in binding and stabilization of factor VIII.

1991 • 159 citations

The affinity and stoichiometry of binding of human factor VIII to von Willebrand factor

1995 • 143 citations

An immunogenic region within residues Val1670-Glu1684 of the factor VIII light chain induces antibodies which inhibit binding of factor VIII to von Willebrand factor.

1988 • 136 citations

von Willebrand factor mediates protection of factor VIII from activated protein C-catalyzed inactivation

1991 • 125 citations

Human von Willebrand factor: a multivalent protein composed of identical subunits

1986 • 120 citations

Disorders of Hemostasis

1991 • 115 citations

A Mechanism for Inhibition of Factor VIII Binding to Phospholipid by von Willebrand Factor

1995 • 97 citations

[7] Factor VIII and factor VIIIa

1993 • 97 citations

Recombinant, B-domain Deleted Factor VIII (r-VIII SQ): Pharmacokinetics and Initial Safety Aspects in Hemophilia A Patients

1997 • 96 citations

The effect of plasma von Willebrand factor on the binding of human factor VIII to thrombin-activated human platelets.

1991 • 93 citations

Limited proteolysis of human von Willebrand factor by Staphylococcus aureus V-8 protease: isolation and partial characterization of a platelet-binding domain

1986 • 91 citations

Identification and Functional Requirement of Cu(I) and Its Ligands within Coagulation Factor VIII

1997 • 82 citations

Reconstitution of human factor VIII from isolated subunits

1988 • 81 citations

Cleavage of Factor VIII Light Chain Is Required for Maximal Generation of Factor VIIIa Activity

1995 • 77 citations

[15] Determination of rate and equilibrium binding constants for macromolecular interactions by surface plasmon resonance

1994 • 75 citations

A monoclonal antibody to von Willebrand factor (vWF) inhibits factor VIII binding. Localization of its antigenic determinant to a nonadecapeptide at the amino terminus of the mature vWF polypeptide.

1989 • 72 citations

The Role of Cleavage of the Light Chain at Positions Arg1689 or Arg1721 in Subunit Interaction and Activation of Human Blood Coagulation Factor VIII

1995 • 71 citations

Stoichiometry of the porcine factor VIII-von Willebrand factor association.

1987 • 59 citations

Copper‐atom identification in the active and inactive forms of plasma‐derived FVIII and recombinant FVIII‐ΔII

1994 • 59 citations

Pharmacokinetics of Factor VIII in Humans

1992 • 51 citations

Generation of active coagulation factor VIII from isolated subunits.

1988 • 45 citations

Molecular characterization of commercial porcine factor VIII concentrate

1988 • 45 citations

Effects of Copper on the Structure and Function of Factor VIII Subunits: Evidence for an Auxiliary Role for Copper Ions in Cofactor Activity

1998 • 28 citations

von Willebrand factor as a regulator of intrinsic factor X activation.

1994 • 25 citations

Fine epitope mapping of monoclonal antibodies to the NH₂‐terminal part of von Willebrand factor (vWF) by using recombinant and synthetic peptides: interest for the localization of the factor VIII binding domain

1994 • 24 citations

Topography of the human factor VIII-von Willebrand factor complex.

1990 • 15 citations

[4] Immunoradiometric assays for factor VIII antigens: c coagulant protein (antihemophilic factor) and factor VIII-related protein (von willebrand factor)

1982 • 13 citations