An immunogenic region within residues Val1670-Glu1684 of the factor VIII light chain induces antibodies which inhibit binding of factor VIII to von Willebrand factor.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphenylglycoluril

1978 • 4,673 citations

General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.

1985 • 1,650 citations

[12] Determination of total protein

1983 • 1,309 citations

Structure of human factor VIII

1984 • 898 citations

The role of phospholipid and factor VIIIa in the activation of bovine factor X.

1981 • 590 citations

[Changes under the influence of high pressure of certain properties of myosin, actomyosin and actin].

1960 • 499 citations

Stabilization of Factor VIII in Plasma by the von Willebrand Factor

1977 • 421 citations

Proteolytic processing of human factor VIII. Correlation of specific cleavages by thrombin, factor Xa, and activated protein C with activation and inactivation of factor VIII coagulant activity

1986 • 404 citations

Effect of shear rate on platelet interaction with subendothelium in citrated and native blood. I. Shear rate--dependent decrease of adhesion in von Willebrand's disease and the Bernard-Soulier syndrome.

1978 • 368 citations

Construction and characterization of an active factor VIII variant lacking the central one-third of the molecule

1986 • 275 citations

A major factor VIII binding domain resides within the amino-terminal 272 amino acid residues of von Willebrand factor.

1987 • 263 citations

Response to infusions of polyelectrolyte fractionated human factor VIII concentrate in human haemophilia A and von Willebrand's disease

1982 • 180 citations

Monoclonal antibodies to porcine factor VIII coagulant and their use in the isolation of active coagulant protein

1982 • 178 citations

Purified human factor VIII procoagulant protein: comparative hemostatic response after infusions into hemophilic and von Willebrand disease dogs.

1985 • 175 citations

Characterization of the human factor VIII procoagulant protein with a heterologous precipitating antibody.

1982 • 169 citations

Shear Rate Dependent Inhibition of Platelet Adhesion and Aggregation on Collagenous Surfaces by Antibodies to Human Factor VIII/von Willebrand Factor

1980 • 156 citations

Purification of human factor VIII:C and its characterization by Western blotting using monoclonal antibodies

1985 • 142 citations

Thrombin proteolysis of purified factor viii procoagulant protein: correlation of activation with generation of a specific polypeptide

1983 • 123 citations

Immunologic Studies in von Willebrand's Disease

1972 • 105 citations

Factor VIII binds to von Willebrand factor via its Mr-80000 light chain

1987 • 89 citations

Activation of factor X by factors IXa and VIII; a specific assay for factor IXa in the presence of thrombin-activated factor VIII

1978 • 86 citations

Human factor VIII: a calcium-linked protein complex

1983 • 73 citations

The effect of thrombin on the complex between factor VIII and von Willebrand factor

1987 • 63 citations

Human factor VIII procoagulant protein. Monoclonal antibodies define precursor-product relationships and functional epitopes.

1985 • 61 citations

The Defect in Hemophilic and von Willebrand's Disease Plasmas Studied by a Recombination Technique

1974 • 45 citations

The Dissociation of Factor VIII by Reducing Agents, High Salt Concentration and Affinity Chromatography

1976 • 43 citations

Homosexual men with thrombocytopenia have impaired reticuloendothelial system Fc receptor-specific clearance

1987 • 28 citations

Studies on the relationship between factor VIII related antigen (VIIIRAg) and factor VIII clotting antigen (VIIICAg) by immunoelectrophoresis and autoradiography using 125I anti VIIICAg

1981 • 19 citations

Dissociation of Factor VIII Procoagulant Antigen VIII : CAg and Factor VIII Related Antigen VIIIR : Ag by EDTA - Influence of Divalent Cation on the Binding of VIII: CAg and VIIIR :Ag

1983 • 15 citations