The coordinate regulation of the p53 and mTOR pathways in cells

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

2015 • 15,801 citations

p53, the Cellular Gatekeeper for Growth and Division

1997 • 7,621 citations

Surfing the p53 network

2000 • 6,487 citations

Role of AMP-activated protein kinase in mechanism of metformin action

2001 • 5,086 citations

Upstream and downstream of mTOR

2004 • 4,085 citations

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

2003 • 3,731 citations

Induction of autophagy and inhibition of tumorigenesis by beclin 1

1999 • 3,194 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene

2003 • 2,136 citations

Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor

2003 • 2,041 citations

Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

2004 • 2,039 citations

Tor, a Phosphatidylinositol Kinase Homologue, Controls Autophagy in Yeast

1998 • 1,271 citations

Targeting the PI3K-Akt pathway in human cancer

2003 • 1,262 citations

Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin

1997 • 953 citations

Dysregulation of the TSC-mTOR pathway in human disease

2004 • 952 citations

Regulation of PTEN Transcription by p53

2001 • 887 citations

Methods for monitoring autophagy

2004 • 882 citations

Cloning and Genomic Organization of Beclin 1, a Candidate Tumor Suppressor Gene on Chromosome 17q21

1999 • 761 citations

Control of p70 S6 kinase by kinase activity of FRAP in vivo

1995 • 717 citations

Regulation and role of autophagy in mammalian cells

2004 • 602 citations

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

2003 • 491 citations

Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR

2003 • 460 citations

p53 alteration is a common event in the spontaneous immortalization of primary BALB/c murine embryo fibroblasts.

1991 • 455 citations

mTOR-Dependent Regulation of Ribosomal Gene Transcription Requires S6K1 and Is Mediated by Phosphorylation of the Carboxy-Terminal Activation Domain of the Nucleolar Transcription Factor UBF†

2003 • 434 citations

Frequent somatic mutations in PTEN and TP53 are mutually exclusive in the stroma of breast carcinomas

2002 • 424 citations

The Peutz-Jegher Gene Product LKB1 Is a Mediator of p53-Dependent Cell Death

2001 • 316 citations

The p53 functional circuit

2001 • 302 citations

The p53MH algorithm and its application in detecting p53-responsive genes

2002 • 292 citations

TOR Signaling

2003 • 222 citations

The PP2A-Associated Protein α4 Is an Essential Inhibitor of Apoptosis

2004 • 148 citations

Raptor and mTOR: Subunits of a Nutrient-Sensitive Complex

2004 • 132 citations

p53 activation results in rapid dephosphorylation of the eIF4E-binding protein 4E-BP1, inhibition of ribosomal protein S6 kinase and inhibition of translation initiation

2002 • 93 citations

Activation of an MDM2-specific Caspase by p53 in the Absence of Apoptosis

1999 • 66 citations