Raptor and mTOR: Subunits of a Nutrient-Sensitive Complex

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

2002 • 2,904 citations

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

1994 • 1,954 citations

TOR, a Central Controller of Cell Growth

2000 • 1,919 citations

Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

2002 • 1,758 citations

Regulation of translation initiation by FRAP/mTOR

2001 • 1,532 citations

The ancient regulatory-protein family of WD-repeat proteins

1994 • 1,478 citations

RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

1994 • 1,470 citations

Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

1998 • 1,319 citations

The WD repeat: a common architecture for diverse functions

1999 • 1,225 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

1998 • 1,136 citations

Phosphatidic Acid-Mediated Mitogenic Activation of mTOR Signaling

2001 • 1,012 citations

Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin

1997 • 953 citations

Mammalian TOR: A Homeostatic ATP Sensor

2001 • 936 citations

ATR and ATRIP: Partners in Checkpoint Signaling

2001 • 935 citations

Isolation of a Protein Target of the FKBP12-Rapamycin Complex in Mammalian Cells

1995 • 859 citations

Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression

1993 • 832 citations

Control of p70 S6 kinase by kinase activity of FRAP in vivo

1995 • 717 citations

A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells.

2000 • 713 citations

Drosophila S6 Kinase: A Regulator of Cell Size

1999 • 710 citations

Disruption of the p70s6k/p85s6k gene reveals a small mouse phenotype and a new functional S6 kinase

1998 • 636 citations

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

1992 • 601 citations

The rapamycin-sensitive signal transduction pathway as a target for cancer therapy

2000 • 587 citations

Regulation of eIF-4E BP1 Phosphorylation by mTOR

1997 • 511 citations

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

1998 • 487 citations

RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex.

1994 • 475 citations

Rapamycin in transplantation: A review of the evidence

2001 • 437 citations

Mitochondrial respiratory chain inhibitors induce apoptosis

1994 • 403 citations

The Immunosuppressant Rapamycin Mimics a Starvation-Like Signal Distinct from Amino Acid and Glucose Deprivation

2002 • 394 citations

Immunopurified Mammalian Target of Rapamycin Phosphorylates and Activates p70 S6 Kinase α in Vitro

1999 • 325 citations

Regulation of cell size in growth, development and human disease: PI3K, PKB and S6K

2002 • 293 citations

Genetic control of cell size

2000 • 243 citations

Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition.

2001 • 229 citations

Metabolic Regulation by Leucine of Translation Initiation Through the mTOR-Signaling Pathway by Pancreatic β-Cells

2001 • 205 citations

Interaction of RAFT1 with Gephyrin Required for Rapamycin-Sensitive Signaling

1999 • 186 citations

Regulation of amino acid-sensitive TOR signaling by leucine analogues in adipocytes

2000 • 164 citations

Turn up the HEAT

1999 • 75 citations

Novel WD-Repeat Protein Mip1p Facilitates Function of the Meiotic Regulator Mei2p in Fission Yeast

2000 • 55 citations

Insulin Signaling and the Control of PHAS-I Phosphorylation

2001 • 26 citations

The respiration of brain mitochondria and its regulation by monovalent cation transport

1979 • 25 citations