Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia

2004 • 2,631 citations

A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain

1999 • 2,051 citations

The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells

2002 • 1,984 citations

Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4

1998 • 1,548 citations

Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene

1992 • 1,510 citations

Linking Colorectal Cancer to Wnt Signaling

2000 • 1,507 citations

Control of endodermal endocrine development by Hes-1

2000 • 1,135 citations

Tissue‐specific and inducible Cre‐mediated recombination in the gut epithelium

2004 • 982 citations

Canonical Wnt signals are essential for homeostasis of the intestinal epithelium

2003 • 982 citations

Notch signals control the fate of immature progenitor cells in the intestine

2005 • 870 citations

Requirement of Math1 for Secretory Cell Lineage Commitment in the Mouse Intestine

2001 • 857 citations

Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation

1999 • 817 citations

Chronic Treatment with the γ-Secretase Inhibitor LY-411,575 Inhibits β-Amyloid Peptide Production and Alters Lymphopoiesis and Intestinal Cell Differentiation

2004 • 709 citations

Inducible gene knockout of transcription factor recombination signal binding protein‐J reveals its essential role in T versus B lineage decision

2002 • 575 citations

Modulation of Notch Processing by γ-Secretase Inhibitors Causes Intestinal Goblet Cell Metaplasia and Induction of Genes Known to Specify Gut Secretory Lineage Differentiation

2004 • 557 citations

SIGNALING PATHWAYS IN INTESTINAL DEVELOPMENT AND CANCER

2004 • 500 citations

Strategies for disease modification in Alzheimer's disease

2004 • 430 citations

Adipsin, a Biomarker of Gastrointestinal Toxicity Mediated by a Functional γ-Secretase Inhibitor

2003 • 343 citations

Genes of the Enhancer of split and achaete-scute complexes are required for a regulatory loop between Notch and Delta during lateral signalling in Drosophila

1996 • 331 citations

Inducible cre-mediated control of gene expression in the murine gastrointestinal tract: effect of loss of β-catenin

2004 • 328 citations

Sensitive Nonradioactive Detection of mRNA in Tissue Sections: Novel Application of the Whole-mount In Situ Hybridization Protocol

2001 • 319 citations

An overview of the Notch signalling pathway

2003 • 309 citations

Hes1is a negative regulator of inner ear hair cell differentiation

2000 • 260 citations

Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine

2005 • 249 citations

A common enzyme connects Notch signaling and Alzheimer's disease

2000 • 214 citations

Expression of Notch pathway components in fetal and adult mouse small intestine

2002 • 160 citations

Expression of Notch Receptors and Ligands in the Adult Gut

2004 • 140 citations

bHLH proteins encoded by theEnhancer of split complex ofDrosophila negatively interfere with transcriptional activation mediated by proneural genes

1994 • 113 citations