The effects of intraperitoneally administered phencyclidine on the central nervous system: Behavioral and neurochemical studies

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Catecholamine innervation of the basal forebrain IV. Topography of the dopamine projection to the basal forebrain and neostriatum

1978 • 1,160 citations

Study of a New Schizophrenomimetic Drug—Sernyl

1959 • 922 citations

An autoradiographic examination of corticocortical and subcortical projections of the mediodorsal‐projection (prefrontal) cortex in the rat

1979 • 787 citations

A subpopulation of mesencephalic dopamine neurons projecting to limbic areas contains a cholecystokinin-like peptide: Evidence from immunohistochemistry combined with retrograde tracing

1980 • 717 citations

Stereotyped activities produced by amphetamine in several animal species and man

1967 • 612 citations

Amphetamine, cocaine, phencyclidine and nomifensine increase extracellular dopamine concentrations preferentially in the nucleus accumbens of freely moving rats

1989 • 562 citations

Phencyclidine-induced psychosis

1978 • 482 citations

A comparison of the distribution of central cholinergic neurons as demonstrated by acetylcholinesterase pharmacohistochemistry and choline acetyltransferase immunohistochemistry

1983 • 407 citations

An observational method for quantifying the behavioural effects of dopamine agonists: Contrasting effects of d-Amphetamine and apomorphine

1980 • 326 citations

Choline acetyltransferase-immunoreactive neurons intrinsic to rodent cortex and distinction from acetylcholinesterase-positive neurons

1984 • 277 citations

Classification and nomenclature of phencyclidine and sigma receptor sites

1987 • 272 citations

Effect of 6‐Hydroxydopamine Lesions of the Medial Prefrontal Cortex on Neurotransmitter Systems in Subcortical Sites in the Rat

1980 • 242 citations

Comparison of the effects of MK-801 and phencyclidine on catecholamine uptake and NMDA-induced norepinephrine release

1988 • 240 citations

Involvement of cholinergic presynaptic receptors of nicotinic and muscarinic types in the control of the spontaneous release of dopamine from striatal dopaminergic terminals in the rat.

1977 • 237 citations

The pharmacology of 1-(1-phenylcyclohexyl) piperidine-HCl.

1959 • 233 citations

Effects of phencyclidine on [3H]catecholamine and [3H]serotonin uptake in synaptosomal preparations from rat brain

1977 • 214 citations

Cholecystokinin peptides produce marked reduction of dopamine turnover in discrete areas in the rat brain following intraventricular injection

1980 • 196 citations

A STUDY OF A 1-ARYL CYCLO HEXYL AMINE FOR ANESTHESIA*

1958 • 194 citations

The effects of phencyclidine on the uptake of 3H-catecholamines by rat striatal and hypothalamic synaptosomes

1976 • 161 citations

An Excitant Amino Acid Projection from the Medial Prefrontal Cortex to the Anterior Part of Nucleus Accumbens in the Rat

1985 • 151 citations

[3H]N-[1-(2-Benzo(b)thiophenyl) cycohexyl]piperidine ([3H]BTCP): a new phencyclidine analog selective for the dopamine uptake complex

1988 • 146 citations

In vivo inhibition of striatal acetylcholine turnover by L-DOPA, apomorphine and (+)-amphetamine

1975 • 145 citations

Biochemical investigation on the localization of the cholecystokinin octapeptide in dopaminergic neurons originating from the ventral tegmental area of the rat

1981 • 140 citations

Biological Studies in Schizophrenia

1987 • 138 citations

Mesolimbic and mesocortical dopamine activation induced by phencyclidine: contrasting pattern to striatal response

1987 • 133 citations

The Effect of 1-Arylcyclohexylamine (Sernyl) on Twelve Normal Volunteers

1960 • 125 citations

Phencyclidine-induced stereotyped behavior in rats: Dose response effects and antagonism by neuroleptics

1979 • 125 citations

The effects of intracerebroventricularly injected corticotropin-releasing factor (CRF) on the central nervous system: Behavioural and biochemical studies

1989 • 93 citations

Similar dopamine-releasing effects of phencyclidine and nonamphetamine stimulants in striatal slices.

1982 • 85 citations

Stereotyped behavior correlates better than ataxia with phencyclidine-receptor interactions

1986 • 79 citations

Distribution and Chromatographic Characterisation of Gastrin and Cholecystokinin in the Rat Central Nervous System

1984 • 78 citations

Effects of phencyclidine, amphetamine and related compounds on dopamine release from and uptake into striatal synaptosomes.

1984 • 76 citations

A simple and rapid method for assessing similarities among directly observable behavioral effects of drugs: PCP-like effects of 2-amino-5-phosphonovalerate in rats

1987 • 76 citations

Effect of several dopaminergic drugs and trihexyphenidyl on cholinergic parameters in the rat striatum

1974 • 75 citations

Selective activation of dopaminergic pathways in the mesocortex by compounds that act at the phencyclidine (pcp) binding site: tentative evidence for pcp recognition sites not coupled to n-methyl-d-aspartate (nmda) receptors

1990 • 71 citations

Phencyclidine

1987 • 70 citations

The Distribution and Some Connections of Cholecystokinin Neurons in the Rat Braina

1985 • 70 citations

Phencyclidine-induced locomotor activity in the rat is blocked by 6-hydroxydopamine lesion of the nucleus accumbens: Comparisons to other psychomotor stimulants

1983 • 68 citations

Phencyclidine-induced stereotyped behavior in monkeys: Antagonism by pimozide

1978 • 66 citations

Acute and chronic behavioral interactions between phencyclidine (PCP) and amphetamine: Evidence for a dopaminergic role in some PCP-induced behaviors

1985 • 66 citations

Frequency-dependent muscarinic receptor modulation of acetylcholine and dopamine release from rabbit striatum.

1984 • 63 citations

An assessment of the spontaneous activity of rats administered morphine, phencyclidine, or nicotine using automated and observational methods

1984 • 60 citations

Effects of dopaminergic drugs on phencyclidine-induced behavior in the rat

1981 • 59 citations

Decrease in rat striatal acetylcholine levels by some direct- and indirect-acting dopaminergic antagonists

1975 • 56 citations

Extrahypophyseal distribution of α-melanocyte stimulating hormone (α-MSH)-like immunoreactivity in postmortem brains from normal subjects and Alzheimer-type dementia patients

1986 • 56 citations

Differential effects of phencyclidine (PCP) and ketamine on mesocortical and mesostriatal dopamine release

1989 • 55 citations

History and Pharmacology of PCP and PCP-Related Analogs

1980 • 51 citations

Autoradiographic distribution of phencyclidine receptors in the rat brain using [3H]1-(1-(2-thienyl)cyclohexyl)piperidine ([3H]TCP)

1986 • 50 citations

Phencyclidine: behavioral and biochemical evidence supporting a role for dopamine.

1983 • 50 citations

Apparent lack of a dopaminergic-cholinergic link in the rat nucleus accumbens septi-tuberculum olfactorium

1977 • 42 citations

Homovanillic acid in rat caudate and prefrontal cortex following phencyclidine and amphetamine

1984 • 42 citations

A comparison of the effects of neuroleptics on phencyclidine-induced behaviors in the rat

1981 • 40 citations

Effects of psychoactive agents on acquisition of conditioned pole jumping in rats

1965 • 39 citations

Phencyclidine-induced release of [3H]dopamine from chopped striatal tissue

1982 • 39 citations

Interactions between Δ9-Tetrahydrocannabinol and phencyclidine hydrochloride in rats

1977 • 38 citations

Basis of phencyclidine's ability to decrease the synaptosomal accumulation of 3H-catecholamines

1980 • 38 citations

Effects of phencyclidine on synaptosomal dopamine continuously appearing from phenylalanine: Sensitivity to reserpine

1981 • 31 citations

The effects of intracerebroventricularly injected corticotropin-releasing factor (CRF) on the central nervous system : behavioral and biochemical studies

1989 • 30 citations

Phencyclidine: Effect on the accumulation of 3H-dopamine in synaptic vesicles

1980 • 26 citations

Candidate mechanisms underlying phencyclidine-induced psychosis: an electrophysiological behavioral, and biochemical study.

1982 • 24 citations

Effect of drugs on visually controlled avoidance behavior in rhesus monkeys: a psychophysical analysis

1967 • 24 citations

Phencyclidine and behavior: I. Sensory-motor function, activity level, taste aversion and water intake

1981 • 23 citations

Stimulation of synaptosomal tyrosine hydroxylation by phencyclidine in vitro

1981 • 21 citations

Site of action of phencyclidine. IV. Interaction of phencyclidine and its analogues on ionic channels of the electrically excitable membrane and nicotinic receptor: implications for behavioral effects.

1982 • 16 citations

Activation of forebrain dopamine systems by phencyclidine and footshock stress: evidence for distinct mechanisms

1987 • 14 citations

Cholecystokinin binding sites in the rat forebrain: effects of acute and chronic methamphetamine administration

1989 • 12 citations

Subcortical afferents to the prefrontal cortex: organization of mesencephalic dopaminergic and mediodorsal thalamic projections.

1977 • 12 citations

Presynaptic regulation of striatal dopamine release: in vivo and in vitro studies.

1982 • 11 citations

Similar potency ratios of amphetamine optical isomers for inhibition of dopamine uptake by synaptosomes of corpus striatum, olfactory tubercle and prefrontal cortex of the rat

1984 • 5 citations