Kinetics of tumour necrosis factor-alpha, soluble tumour necrosis factor receptors, interleukin 1-beta and its receptor antagonist during serious infections

Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia

1987 • 2,492 citations

Passive Immunization Against Cachectin/Tumor Necrosis Factor Protects Mice from Lethal Effect of Endotoxin

1985 • 2,380 citations

Detection of Circulating Tumor Necrosis Factor after Endotoxin Administration

1988 • 1,711 citations

Surgery, Gynecology and obstetrics.

2012 • 1,562 citations

The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome.

1989 • 1,183 citations

ASSOCIATION BETWEEN TUMOUR NECROSIS FACTOR IN SERUM AND FATAL OUTCOME IN PATIENTS WITH MENINGOCOCCAL DISEASE

1987 • 1,108 citations

The Cardiovascular Response of Normal Humans to the Administration of Endotoxin

1989 • 1,096 citations

Interleukin 1 induces a shock-like state in rabbits. Synergism with tumor necrosis factor and the effect of cyclooxygenase inhibition.

1988 • 990 citations

Interleukin-1 receptor antagonist reduces mortality from endotoxin shock

1990 • 865 citations

Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo.

1992 • 842 citations

Stabilization of the bioactivity of tumor necrosis factor by its soluble receptors.

1992 • 832 citations

Cytokine Serum Level During Severe Sepsis in Human IL-6 as a Marker of Severity

1992 • 799 citations

Circulating Interleukin-1 and Tumor Necrosis Factor in Septic Shock and Experimental Endotoxin Fever

1990 • 765 citations

Tumor Necrosis Factor and Interleuktn-1 in the Serum of Children with Severe Infectious Purpura

1988 • 735 citations

Activation of Coagulation after Administration of Tumor Necrosis Factor to Normal Subjects

1990 • 681 citations

Interleukin 1 receptor antagonist. A new member of the interleukin 1 family.

1991 • 589 citations

Prognostic Values of Tumor Necrosis Factor/Cachectin, Interleukin-l, Interferon- , and Interferon- in the Serum of Patients with Septic Shock

1990 • 555 citations

Cytokine appearance in human endotoxemia and primate bacteremia.

1988 • 528 citations

Initial evaluation of human recombinant interleukin-1 receptor antagonist in the treatment of sepsis syndrome: A randomized, open-label, placebocontrolled multicenter trial

1994 • 488 citations

Tumor necrosis factor and interleukin-1 serum levels during severe sepsis in humans

1989 • 485 citations

The Proinflammatory Cytokines Interleukin-l and Tumor Necrosis Factor and Treatment of the Septic Shock Syndrome

1991 • 409 citations

Plasma Tumor Necrosis Factor in Patients with Septic Shock: Mortality Rate, Incidence of Adult Respiratory Distress Syndrome, and Effects of Methylprednisolone Administration

1990 • 335 citations

Coordinated antiinflammatory effects of interleukin 4: interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist.

1992 • 324 citations

Plasma tumor necrosis factor and mortality in critically ill septic patients

1989 • 324 citations

Production of interleukin-1-receptor antagonist during experimental endotoxaemia

1991 • 311 citations

A recombinant human receptor antagonist to interleukin 1 improves survival after lethal endotoxemia in mice.

1991 • 298 citations

Production of tumor necrosis factor during murine listeriosis.

1987 • 241 citations

Clinical pharmacology of recombinant human tumor necrosis factor in patients with advanced cancer.

1987 • 216 citations

Imbalance between tumour necrosis factor-alpha and soluble TNF receptor concentrations in severe meningococcaemia. The J5 Study Group.

1992 • 203 citations

Production of interleukin-1 receptor antagonist and interleukin-1 beta by peripheral blood mononuclear cells is differentially regulated

1991 • 201 citations

Influence of nephrectomy on tumor necrosis factor clearance in a murine model.

1993 • 182 citations

Differential Expression of Proinflammatory Cytokines and Their Inhibitors during the Course of Meningococcal Infections

1994 • 175 citations

Cytokines and the response to infection

1992 • 162 citations

Meningococcal septicaemia treated with combined plasmapheresis and leucapheresis or with blood exchange.

1984 • 149 citations

Protective Effects of Tumor Necrosis Factor in Experimental Legionella pneumophila Infections of Mice via Activation of PMN Function

1988 • 133 citations

PLASMA AND WHOLE BLOOD EXCHANGE IN MENINGOCOCCAL SEPSIS

1993 • 100 citations

Soluble and cell surface receptors for tumor necrosis factor

1992 • 66 citations

Involvement of tumor necrosis factor alpha in intracellular multiplication of Legionella pneumophila in human monocytes

1993 • 45 citations

Molecular mechanisms in the compartmentalized inflammatory response presenting as meningococcal meningitis or septic shock

1992 • 42 citations

A tumor necrosis factor binding protein (TNF-BP)-physiological antagonist of TNF

1991 • 7 citations

INCIDENCE AND CONSEQUENCES OF MULTIPLE ORGAN DYSFUNCTION SYNDROME AFTER ABDOMINAL AORTIC RECONSTRUCTION

1994 • 6 citations