N -Acetylcysteine in Combination With Nitroglycerin and Streptokinase for the Treatment of Evolving Acute Myocardial Infarction

The thrombolysis in myocardial infarction (TIMI) trial. Phase I findings

1985 • 3,610 citations

The Thrombolysis in Myocardial Infarction (TIMI) Trial

1985 • 3,078 citations

EFFECTIVENESS OF INTRAVENOUS THROMBOLYTIC TREATMENT IN ACUTE MYOCARDIAL INFARCTION

1986 • 2,315 citations

The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid

1989 • 1,769 citations

RANDOMISED TRIAL OF INTRAVENOUS STREPTOKINASE, ORAL ASPIRIN, BOTH, OR NEITHER AMONG 17 187 CASES OF SUSPECTED ACUTE MYOCARDIAL INFARCTION: ISIS-2

1988 • 848 citations

Lipoperoxides in plasma as measured by liquid-chromatographic separation of malondialdehyde-thiobarbituric acid adduct.

1987 • 817 citations

[39] Assay for blood plasma or serum

1984 • 765 citations

Demonstration of free radical generation in "stunned" myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone.

1988 • 691 citations

Direct detection of free radicals in the reperfused rat heart using electron spin resonance spectroscopy.

1987 • 628 citations

Effect of Intravenous Streptokinase on Left Ventricular Function and Early Survival after Acute Myocardial Infarction

1987 • 628 citations

[35] Comparative studies on different methods of malonaldehyde determination

1984 • 536 citations

Intermittent Coronary Occlusion in Acute Myocardial Infarction

1987 • 373 citations

Prevention and Reversal of Nitrate Tolerance in Patients with Congestive Heart Failure

1987 • 366 citations

Occurrence of oxidative stress during reperfusion of the human heart.

1990 • 297 citations

Reperfusion arrhythmia: A marker of restoration of antegrade flow during intracoronary thrombolysis for acute myocardial infarction

1983 • 277 citations

Oxygen free radicals and myocardial damage: Protective role of thiol-containing agents

1991 • 240 citations

Noninvasive detection of coronary artery patency using continuous ST-segment monitoring

1986 • 234 citations

Limitation of myocardial infarction by early infusion of recombinant tissue-type plasminogen activator.

1988 • 232 citations

Early recovery of left ventricular function after thrombolytic therapy for acute myocardial infarction: An important determinant of survival

1988 • 200 citations

Potentiation of the cardiovascular effects of nitroglycerin by N-acetylcysteine.

1983 • 192 citations

N-Acetylcysteine potentiates inhibition of platelet aggregation by nitroglycerin.

1985 • 188 citations

The role of glutathione status in the protection against ischaemic and reperfusion damage: Effects of N-acetyl cysteine

1988 • 178 citations

Reperfusion injury: laboratory artifact or clinical dilemma?

1986 • 174 citations

In Vivo Induction and Reversal of Nitroglycerin Tolerance in Human Coronary Arteries

1987 • 169 citations

Continuously updated 12-lead ST-segment recovery analysis for myocardial infarct artery patency assessment and its correlation with multiple simultaneous early angiographic observations

1993 • 167 citations

The determination of glutathione, cyst(e)ine, and other thiols and disulfides in biological samples using high-performance liquid chromatography with dual electrochemical detection

1987 • 156 citations

Angiographic validation of bedside markers of reperfusion

1993 • 145 citations

Plasma malonaldehyde levels during myocardial infarction

1983 • 142 citations

Simultaneous separation of malondialdehyde, ascorbic acid, and adenine nucleotide derivatives from biological samples by ion-pairing high-performance liquid chromatography

1991 • 125 citations

Glutathione redox pathway and reperfusion injury. Effect of N-acetylcysteine on infarct size and ventricular function.

1988 • 113 citations

Combined use of nitroglycerin and N-acetylcysteine in the management of unstable angina pectoris.

1988 • 111 citations

Myocardial infarct extension during reperfusion after coronary artery occlusion: Pathologic evidence

1993 • 111 citations

Potentiation of nitroglycerin-induced coronary dilatation by N-acetylcysteine.

1986 • 108 citations

Myocardial glutathione depletion impairs recovery after short periods of ischemia.

1989 • 103 citations

Lipid peroxidation associated with successful thrombolysis

1990 • 101 citations

Lipid peroxidation and protective enzymes during myocardial infarction

1991 • 99 citations

The unstable ST segment early after thrombolysis for acute infarction and its usefulness as a marker of recurrent coronary occlusion

1991 • 97 citations

Relation between myocardial glutathione content and extent of ischemia-reperfusion injury.

1989 • 89 citations

Cardioprotective effects of N-acetylcysteine: the reduction in the extent of infarction and occurrence of reperfusion arrhythmias in the dog

1990 • 65 citations

Lipid Peroxidation and Acute Myocardial Ischemia

1983 • 63 citations

Lipid peroxidation and antioxidant status following thrombolytic therapy for acute myocardial infarction

1993 • 55 citations

N-Acetylcysteine enhances nitroglycerin-induced headache and cranial arterial responses

1992 • 54 citations

Free-radical generation during angioplasty reperfusion for acute myocardial infarction

1993 • 50 citations

Peroxidative modification of phospholipids in myocardial membranes

1990 • 50 citations

Serum malondialdehyde-like material (MDA-LM) in acute myocardial infarction.

1983 • 49 citations

Electrochemical determination of femtomole amounts of free reduced and oxidized glutathione

1992 • 44 citations

Determination of cysteine, glutathione and N-acetylcysteine in plasma by ion-pair reversed-phase liquid chromatography and post-column derivatization

1988 • 32 citations

Altered peripheral vesodilator profile of nitroglycerin during long-term infusion of N-acetylcysteine

1994 • 30 citations

Reversible effect of calcium-binding protein regucalcin on the Ca2+-induced inhibition of deoxyuridine 5′-triphosphatase activity in rat liver cytosol

1992 • 29 citations

Total recovery of left ventricular function after acute myocardial infarction: comprehensive therapy with streptokinase, N-acetylcysteine and percutaneous transluminal coronary angioplasty

1992 • 25 citations

Effectiveness of thrombolysis is associated with a time-dependent increase of malondialdehyde in peripheral blood of patients with acute myocardial infarction

1993 • 23 citations

Free radical activity and left ventricular function after thrombolysis for acute infarction.

1993 • 21 citations

High-performance liquid chromatographic separation of subcomponents of antimycin A

1988 • 19 citations

Captopril potentiates the effects of nitroglycerin in the coronary vascular bed

1993 • 19 citations

Concurrent nitroglycerin therapy impairs tissue-type plasminogen activator-induced thrombolysis in patients with acute myocardial infarction

1994 • 18 citations

Time-course of cardiac myocyte injury due to oxidative stress

1992 • 17 citations

The Evolution of Oxidative Stress Indicators in the Course of Myocardial Ischemia

1991 • 10 citations

Incidence of adverse events during treatment with verapamil for suspected acute myocardial infarction

1992 • 8 citations