Repetitive Intrathecal Injections of Poliovirus Replicons Result in Gene Expression in Neurons of the Central Nervous System Without Pathogenesis

Adhesion receptors of the immune system

1990 • 6,585 citations

A Sensitive and Reliable Locomotor Rating Scale for Open Field Testing in Rats

1995 • 4,199 citations

NeuN, a neuronal specific nuclear protein in vertebratesxs

1992 • 2,268 citations

Microglia: Intrinsic immuneffector cell of the brain

1995 • 1,099 citations

Objective clinical assessment of motor function after experimental spinal cord injury in the rat

1977 • 690 citations

NeuN: a useful neuronal marker for diagnostic histopathology.

1996 • 507 citations

Systemically Administered Interleukin-10 Reduces Tumor Necrosis Factor-Alpha Production and Significantly Improves Functional Recovery Following Traumatic Spinal Cord Injury in Rats

1999 • 404 citations

Spinal cord contusion in the rat: Behavioral analysis of functional neurologic impairment☆

1985 • 382 citations

Transgenic mice expressing a human poliovirus receptor: A new model for poliomyelitis

1990 • 379 citations

Foot-and-mouth disease virus 2A oligopeptide mediated cleavage of an artificial polyprotein.

1994 • 367 citations

Expression of Pro‐Inflammatory Cytokine and Chemokine mRNA Upon Experimental Spinal Cord Injury in Mouse: an In Situ Hybridization Study

1997 • 354 citations

Neuronal nuclear antigen (NeuN): a marker of neuronal maturation in the early human fetal nervous system

1998 • 298 citations

Adenovirus gene transfer causes inflammation in the brain

1995 • 283 citations

Emerging Concept of Poliomyelitis Infection

1955 • 252 citations

Histopathologic basis of clinical findings in poliomyelitis

1949 • 204 citations

Robust Growth of Chronically Injured Spinal Cord Axons Induced by Grafts of Genetically Modified NGF-Secreting Cells

1997 • 194 citations

The cleavage activities of aphthovirus and cardiovirus 2A proteins.

1997 • 172 citations

Poliovirus Spreads from Muscle to the Central Nervous System by Neural Pathways

1992 • 160 citations

Viral vectors, tools for gene transfer in the nervous system

1998 • 142 citations

MHC I-dependent antigen presentation is inhibited by poliovirus protein 3A

2000 • 141 citations

Poliovirus Protease 3Cpro Kills Cells by Apoptosis

2000 • 135 citations

A Mouse Model of Graded Contusive Spinal Cord Injury

1998 • 132 citations

Poliovirus 2A Protease Induces Apoptotic Cell Death

2000 • 122 citations

Targeted Transduction of CNS Neurons with Adenoviral Vectors Carrying Neurotrophic Factor Genes Confers Neuroprotection That Exceeds the Transduced Population

1997 • 117 citations

Prevention of motoneuron death by adenovirus-mediated neurotrophic factors

1997 • 106 citations

Immunohistochemical detection of T-cell subsets and other leukocytes in paraffin-embedded rat and mouse tissues with monoclonal antibodies.

1995 • 103 citations

Inflammatory effects of gene transfer into the CNS with defective HSV-1 vectors.

1994 • 101 citations

NT-3 delivered by an adenoviral vector induces injured dorsal root axons to regenerate into the spinal cord of adult rats

1998 • 99 citations

Synergistic but transient rescue effects of BDNF and GDNF on axotomized neonatal motoneurons

1998 • 98 citations

Neuronal cells are deficient in loading peptides onto MHC class I molecules

1992 • 96 citations

Poliovirus Induces Apoptosis in the Mouse Central Nervous System

1999 • 92 citations

Treatment with genetically engineered fibroblasts producing NGF or BDNF can accelerate recovery from traumatic spinal cord injury in the adult rat

1996 • 92 citations

Transient gene transfer to neurons and glia: Analysis of adenoviral vector performance in the CNS and PNS

1997 • 90 citations

Encapsidation of poliovirus replicons encoding the complete human immunodeficiency virus type 1 gag gene by using a complementation system which provides the P1 capsid protein in trans

1995 • 63 citations

Regulation of spinal motoneuron survival by GDNF during development and following injury

1996 • 62 citations

Adenovirus-mediated gene transfer to the brain: methodological assessment

1997 • 61 citations

Encapsidation of genetically engineered poliovirus minireplicons which express human immunodeficiency virus type 1 Gag and Pol proteins upon infection

1993 • 56 citations

Adenoviral vector-directed expression of neurotrophin-3 in rat dorsal root ganglion explants results in a robust neurite outgrowth response

1997 • 48 citations

Neurovirulence Test for Oral Live Poliovaccines Using Poliovirus-Sensitive Transgenic Mice

1995 • 47 citations

Demonstration of the Specificity of Poliovirus Encapsidation Using a Novel Replicon which Encodes Enzymatically Active Firefly Luciferase

1998 • 46 citations

Defective viral vectors as agents for gene transfer in the nervous system

1997 • 44 citations

Complementation of a poliovirus defective genome by a recombinant vaccinia virus which provides poliovirus P1 capsid precursor in trans

1993 • 44 citations

Molecular Aspects of Poliovirus Biology with a Special Focus on the Interactions with Nerve Cells

1998 • 43 citations

Cytokine production in motor neurons by poliovirus replicon vector gene delivery

2000 • 36 citations

Adenoviral-mediated gene transfer to enhance neuronal survival, growth, and regeneration

1999 • 33 citations

Ultrastructural studies on the pathogenesis of poliomyelitis in monkeys infected with polivirus

1984 • 25 citations

Embedding, sectioning, immunocytochemical and stereological methods that optimise research on the lesioned adult rat spinal cord

1995 • 22 citations

Targeted foreign gene expression in spinal cord neurons using poliovirus replicons

2000 • 22 citations

Characterization of mouse lines transgenic with the human poliovirus receptor gene

1998 • 16 citations

Poliomyelitis in Intraspinally Inoculated Poliovirus Receptor Transgenic Mice

1999 • 9 citations