Basal expression of the cystic fibrosis transmembrane conductance regulator gene is dependent on protein kinase A activity.

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

Therapy of CF-Patients with Amitriptyline and Placebo - a Randomised, Double-Blind, Placebo-Controlled Phase IIb Multicenter, Cohort-Study

2013 • 2,504 citations

Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs

1985 • 1,594 citations

Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells.

1990 • 1,507 citations

Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel

1991 • 658 citations

Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression.

1994 • 542 citations

Cystic Fibrosis Heterozygote Resistance to Cholera Toxin in the Cystic Fibrosis Mouse Model

1994 • 483 citations

Calcium and cAMP activate different chloride channels in the apical membrane of normal and cystic fibrosis epithelia.

1991 • 373 citations

Relationship of a non-cystic fibrosis transmembrane conductance regulator-mediated chloride conductance to organ-level disease in Cftr(-/-) mice.

1994 • 344 citations

Effect of Deleting the R Domain on CFTR-Generated Chloride Channels

1991 • 271 citations

Regulation of transcription by cyclic AMP-dependent protein kinase.

1989 • 247 citations

Regulation of the cystic fibrosis transmembrane conductance regulator Cl- channel by specific protein kinases and protein phosphatases.

1993 • 246 citations

Both the basal and inducible transcription of the tyrosine hydroxylase gene are dependent upon a cAMP response element

1993 • 207 citations

A Protein Kinase Inhibitor Gene Reduces Both Basal and Multihormone-stimulated Prolactin Gene Transcription

1989 • 203 citations

The cystic fibrosis gene has a “housekeeping”-type promoter and is expressed at low levels in cells of epithelial origin

1991 • 170 citations

A DNA motif related to the cAMP-responsive element and an exon-located activator protein-2 binding site in the human tissue-type plasminogen activator gene promoter cooperate in basal expression and convey activation by phorbol ester and cAMP.

1990 • 135 citations

Mutations in the catalytic subunit of cAMP-dependent protein kinase result in unregulated biological activity.

1992 • 133 citations

Calcium/Calmodulin-Dependent Protein Kinase Types II and IV Differentially Regulate CREB-Dependent Gene Expression

1994 • 123 citations

Characterization of the cAMP responsive elements from the genes for the alpha-subunit of glycoprotein hormones and phosphoenolpyruvate carboxykinase (GTP). Conserved features of nuclear protein binding between tissues and species.

1988 • 121 citations

Neuron-specific expression of the human dopamine beta-hydroxylase gene requires both the cAMP-response element and a silencer region.

1993 • 120 citations

Regulation of the a Inhibin Gene by Cyclic Adenosine 3′,5′-Monophosphate after Transfection into Rat Granulosa Cells

1991 • 115 citations

Characterization of the promoter region of the cystic fibrosis transmembrane conductance regulator gene.

1991 • 99 citations

Characterization of the cystic fibrosis transmembrane conductance regulator promoter region. Chromatin context and tissue-specificity

1993 • 95 citations

Down-regulation of cystic fibrosis gene mRNA transcript levels and induction of the cystic fibrosis chloride secretory phenotype in epithelial cells by phorbol ester

1991 • 94 citations

Functional Characterization of cAMP-binding Mutations in Type I Protein Kinase

1989 • 65 citations

Interaction of nucleotides with membrane-associated cystic fibrosis transmembrane conductance regulator

1993 • 61 citations

Multiple DNA elements responsible for transcriptional regulation of the ornithine decarboxylase gene by protein kinase A.

1992 • 46 citations

Cyclic AMP-dependent protein kinase controls basal gene activity and steroidogenesis in Y1 adrenal tumor cells

1992 • 44 citations

Mutations in the catalytic subunit of the cAMP-dependent protein kinase interfere with holoenzyme formation without disrupting inhibition by protein kinase inhibitor.

1993 • 44 citations

Binding Specificity of Cyclic Adenosine 3′,5′-Monophosphate- Responsive Element (CRE)-Binding Proteins and Activating Transcription Factors to Naturally Occurring CRE Sequence Variants

1991 • 43 citations

Plasmids encoding PKI(1–31), a specific inhibitor of cAMP-stimulated gene expression, inhibit the basal transcriptional activity of some but not all cAMP-regulated DNA response elements in JEG-3 cells

1989 • 42 citations

Induction of expression of the cystic fibrosis transmembrane conductance regulator.

1992 • 41 citations

Down-regulation of cystic fibrosis transmembrane conductance regulator gene expression by agents that modulate intracellular divalent cations.

1992 • 34 citations

Regulation of Cl- transport in T84 cell clones expressing a mutant regulatory subunit of cAMP-dependent protein kinase.

1990 • 33 citations

(Dys)regulation of epithelial chloride channels

1989 • 33 citations

Mechanism of inhibition of cAMP-dependent epithelial chloride secretion by phorbol esters.

1993 • 31 citations

Effect of modulation of protein kinase C on the cAMP‐dependent chloride conductance in T84 cells

1992 • 28 citations

Down-Regulation of Cystic Fibrosis Transmembrane Conductance Regulator Gene Expression by Agents That Modulate Intracellular Divalent Cations

1992 • 14 citations