Broccoli: A Unique Vegetable That Protects Mammalian Hearts through the Redox Cycling of the Thioredoxin Superfamily

Mitochondria and Apoptosis

1998 • 8,909 citations

Thioredoxin and Glutaredoxin Systems

1989 • 1,778 citations

A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.

1992 • 1,647 citations

Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

2003 • 1,353 citations

[21] Thioredoxin and thioredoxin reductase

1995 • 932 citations

Thioredoxin reductase

2000 • 543 citations

Oxidoreductive regulation of nuclear factor kappa B. Involvement of a cellular reducing catalyst thioredoxin

1993 • 490 citations

Dietary Flavonoid Intake and Risk of Cardiovascular Disease in Postmenopausal Women

1999 • 430 citations

Redox Potentials of Glutaredoxins and Other Thiol-Disulfide Oxidoreductases of the Thioredoxin Superfamily Determined by Direct Protein-Protein Redox Equilibria

1997 • 403 citations

Glutaredoxin 2 Catalyzes the Reversible Oxidation and Glutathionylation of Mitochondrial Membrane Thiol Proteins

2004 • 391 citations

Identification of Sensor Cysteines in Human Keap1 Modified by the Cancer Chemopreventive Agent Sulforaphane

2005 • 385 citations

Human Mitochondrial Glutaredoxin Reduces S-Glutathionylated Proteins with High Affinity Accepting Electrons from Either Glutathione or Thioredoxin Reductase

2004 • 305 citations

New Roles for Src Kinases in Control of Cell Survival and Angiogenesis

2000 • 301 citations

Selenium metabolism and bioavailability

1996 • 286 citations

Characterization of human glutaredoxin 2 as iron–sulfur protein: A possible role as redox sensor

2005 • 276 citations

Transgene overexpression of αB crystallin confers simultaneous protection against cardiomyocyte apoptosis and necrosis during myocardial ischemia and reperfusion

2001 • 217 citations

Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome

2004 • 203 citations

Epithiospecifier Protein from Broccoli (Brassica oleracea L. ssp. italica) Inhibits Formation of the Anticancer Agent Sulforaphane

2006 • 198 citations

Sulforaphane Induces Thioredoxin through the Antioxidant-Responsive Element and Attenuates Retinal Light Damage in Mice

2005 • 187 citations

Thioredoxin redox signaling in the ischemic heart: an insight with transgenic mice overexpressing Trx1

2003 • 149 citations

SAPKs regulation of ischemic preconditioning

2000 • 139 citations

Measurements of Plasma Glutaredoxin and Thioredoxin in Healthy Volunteers and During Open-Heart Surgery

1998 • 126 citations

Determination of sulforaphane in broccoli and cabbage by high-performance liquid chromatography

2006 • 124 citations

Phase 1 study of multiple biomarkers for metabolism and oxidative stress after one‐week intake of broccoli sprouts

2004 • 113 citations

Selenite protects human endothelial cells from oxidative damage and induces thioredoxin reductase

2001 • 111 citations

Hypoxic preconditioning preserves antioxidant reserve in the working rat heart

1995 • 108 citations

Elevated circulating levels of thioredoxin and stress in chronic heart failure

2004 • 98 citations

Selenium content of foods purchased in North Dakota

1996 • 91 citations

Selenium Enrichment of Broccoli: Interactions between Selenium and Secondary Plant Compounds

2005 • 88 citations

Reduction of Cancer Risk by Consumption of Selenium-Enriched Plants: Enrichment of Broccoli with Selenium Increases the Anticarcinogenic Properties of Broccoli

2003 • 84 citations

Targeted disruption of peroxiredoxin 6 gene renders the heart vulnerable to ischemia-reperfusion injury

2006 • 82 citations

Glucoraphanin, the bioprecursor of the widely extolled chemopreventive agent sulforaphane found in broccoli, induces Phase-I xenobiotic metabolizing enzymes and increases free radical generation in rat liver

2006 • 76 citations

Selenite protects human endothelial cells from oxidative damage and induces thioredoxin reductase

2001 • 71 citations

Broccoli sprouts as inducers of carcinogen-detoxifying enzyme systems: Clinical, dietary, and policy implications

1997 • 60 citations

Conversion of Death Signal into Survival Signal by Redox Signaling

2004 • 60 citations

Src tyrosine kinase is the trigger but not the mediator of ischemic preconditioning

2001 • 57 citations

Selenite Incubated with NADPH and Mammalian Thioredoxin Reductase Yields Selenide, Which Inhibits Lipoxygenase and Changes the Electron Spin Resonance Spectrum of the Active Site Iron

1996 • 53 citations

Thioredoxin Regulation of Ischemic Preconditioning

2004 • 46 citations

Redox activation of Ref-1 potentiates cell survival following myocardial ischemia reperfusion injury

2007 • 44 citations

Ischemic Preconditioning Triggers Nuclear Translocation of Thioredoxin and Its Interaction with Ref-1 Potentiating a Survival Signal Through the PI-3-Kinase-Akt Pathway

2006 • 40 citations

RETRACTED: Role of glutaredoxin-1 in cardioprotection: An insight with Glrx1 transgenic and knockout animals

2007 • 36 citations

Modulation of the Thioredoxin System During Inflammatory Responses and Its Effect on Heme Oxygenase-1 Expression

2002 • 32 citations

Cutaneous Arteriolar Thioredoxin Expression in Patients With Heart Failure.

2003 • 27 citations

Upregulation of redox-regulating protein, thioredoxin, in endomyocardial biopsy samples of patients with myocarditis and cardiomyopathies.

2003 • 24 citations