Ceroid/Lipofuscin-loaded human fibroblasts show increased susceptibility to oxidative stress

Free radicals in biology and medicine

1991 • 17,840 citations

Free Radicals in Biology and Medicine

1990 • 4,962 citations

Lysosomotropic agents

1974 • 1,887 citations

Importance of SE-glutathione peroxidase, catalase, and CU/ZN-SOD for cell survival against oxidative stress

1994 • 1,178 citations

Mild Hyperoxia Shortens Telomeres and Inhibits Proliferation of Fibroblasts: A Model for Senescence?

1995 • 849 citations

Ultrastructural Pathology of the Cell and Matrix

1988 • 808 citations

Oxidative DNA damage and senescence of human diploid fibroblast cells.

1995 • 697 citations

Molecular analysis of H2O2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication

1998 • 436 citations

Human skin fibroblasts in vitro differentiate along a terminal cell lineage.

1988 • 400 citations

Rate And Magnitude Of Age Pigment Accumulation In The Human Myocardium

1959 • 336 citations

SARPs: A family of secreted apoptosis-related proteins

1997 • 327 citations

Correlates of p53- and Fas (CD95)-mediated apoptosis in Alzheimer's disease

1997 • 300 citations

Transient Adaptation to Oxidative Stress in Mammalian Cells

1995 • 300 citations

Photo-Oxidative Disruption of Lysosomal Membranes Causes Apoptosis of Cultured Human Fibroblasts

1997 • 282 citations

A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosis

1992 • 270 citations

Ultrastructural Pathology of the Cell and Matrix

1988 • 268 citations

Oxidative stress causes relocation of the lysosomal enzyme cathepsin D with ensuing apoptosis in neonatal rat cardiomyocytes.

1998 • 263 citations

Presenilins, the Endoplasmic Reticulum, and Neuronal Apoptosis in Alzheimer's Disease

1998 • 247 citations

Cellular injury induced by oxidative stress is mediated through lysosomal damage

1995 • 240 citations

MORPHOLOGIC CHANGES ACCOMPANYING SENESCENCE OF CULTURED HUMAN DIPLOID CELLS

1970 • 239 citations

Oxidative stress, growth factor starvation and Fas activation may all cause apoptosis through lysosomal leak

1999 • 183 citations

Effect of hydroxy substituent position on 1,4-naphthoquinone toxicity to rat hepatocytes.

1991 • 160 citations

Apoptosis Decision Cascades and Neuronal Degeneration in Alzheimer’s Disease

1998 • 146 citations

Ceroid/lipofuscin formation in cultured human fibroblasts: the role of oxidative stress and lysosomal proteolysis

1998 • 131 citations

HISTOCHEMICAL INDICATIONS FOR LYSOSOMAL LOCALIZATION OF HEAVY METALS IN NORMAL RAT BRAIN AND LIVER

1970 • 122 citations

Lipofuscin Accumulation in Cultured Retinal Pigment Epithelial Cells Causes Enhanced Sensitivity to Blue Light Irradiation

1997 • 117 citations

Exposure of cells to nonlethal concentrations of hydrogen peroxide induces degeneration-repair mechanisms involving lysosomal destabilization

1995 • 114 citations

H₂O₂-Mediated Damage to Lysosomal Membranes of J-774 Cells

1993 • 111 citations

Apoptosis as the Mechanism of Neurodegeneration in Batten's Disease

1996 • 103 citations

Residual bodies and "aging" in cultured human glia cells. Effect of entrance into phase 3 and prolonged periods of confluence.

1973 • 99 citations

Lipofuscin and Ceroid Formation: The Cellular Recycling System

1990 • 99 citations

Chapter 11 Lipofuscin: characteristics and significance

1986 • 96 citations

Increased Expression of Cathepsins E and D in Neurons of the Aged Rat Brain and Their Colocalization with Lipofuscin and Carboxy‐Terminal Fragments of Alzheimer Amyloid Precursor Protein

1997 • 95 citations

Advances in age pigment research

1991 • 90 citations

Importance of various antioxidant enzymes for cell stability. Confrontation between theoretical and experimental data

1992 • 90 citations

LIPOFUSCIN ACCUMULATION AND AGEING OF FIBROBLASTS

1995 • 89 citations

Effect of ambient oxygen concentration on lipofuscin accumulation in cultured rat heart myocytes—A novel in vitro model of lipofuscinogenesis

1989 • 88 citations

LIPOFUSCIN IN BOVINE MUSCLE AND BRAIN: A MODEL FOR STUDYING AGE PIGMENT

1995 • 87 citations

Lethal hydrogen peroxide toxicity involves lysosomal iron-catalyzed reactions with membrane damage

1995 • 83 citations

Comparative ultrastructure of chick fibroblasts in vitro at early and late stages during their growth span

1971 • 82 citations

Residual bodies and “aging” in cultured human glia cells

1973 • 77 citations

On the degradability and exocytosis of ceroid/lipofuscin in cultured rat cardiac myocytes

1998 • 77 citations

Similar Gene Expression Pattern in Senescent and Hyperoxic-Treated Fibroblasts

1998 • 74 citations

Endogenous ferritin protects cells with iron-laden lysosomes against oxidative stress

1998 • 73 citations

Upregulation of Bcl-2 and Elevation of Ceramide in Batten Disease

1997 • 64 citations

Induction of Apoptosis through the PKC Pathway in Cultured Dermal Papilla Fibroblasts

1997 • 57 citations

Altered cellular responsiveness during ageing

1991 • 54 citations

On the Cytoprotective Role of Ferritin in Macrophages and its Ability to Enhance Lysosomal Stability

1997 • 47 citations

Ultrastructural and cytochemical changes in cultured human lung cells

1972 • 44 citations

Autofluorescence as an index of ageing in human fibroblasts in culture

1982 • 40 citations

Oxidant-induced apoptosis: a consequence of lethal lysosomal leak?

1997 • 35 citations

On the Origin of Lipofuscin; The Iron Content of Residual Bodies, and the Relation of These Organelles to the Lysosomal Vacuome. A Study on Cultured Human Glial Cells

1990 • 33 citations

Increased susceptibility of late passage human diploid fibroblasts to oxidative stress

1996 • 31 citations

A short exposure to a high‐glucose milieu stabilizes the acidic vacuolar apparatus of insulinoma cells in culture to ensuing oxidative stress

1997 • 26 citations

ULTRASTRUCTURAL STUDIES OF THE RETINA IN INFANTILE NEURONAL CEROID-LIPOFUSCINOSIS

1988 • 26 citations

Reciprocal Relationships between the Resistance to Stresses and Cellular Aginga

1998 • 23 citations

Dolichol and dolichyl phosphate in the neuronal ceroid-lipofuscinoses and other diseases

1988 • 22 citations

Glutathione content of cultured human fibroblasts during in vitro ageing

1984 • 13 citations

IMPLICATIONS OF INCREASED INTERCELLULAR VARIABILITY OF LIPOFUSCIN CONTENT WITH AGE IN DENTATE GYRUS GRANULE CELLS IN THE MOUSE

1995 • 7 citations

DIET-INDUCED RESIDUAL FORMATION IN PIGS

1995 • 5 citations