Aflatoxin B1-induced TP53 mutational pattern in normal human cells using the FASAY (Functional Analysis of Separated Alleles in Yeast)

Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell lines.

1988 • 2,320 citations

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

1991 • 1,525 citations

Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

1991 • 1,418 citations

Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers

2002 • 1,050 citations

Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome.

2000 • 663 citations

TP53 mutations and hepatocellular carcinoma: insights into the etiology and pathogenesis of liver cancer

2007 • 581 citations

Structural identification of the major DNA adduct formed by aflatoxin B1 in vitro.

1977 • 507 citations

Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes.

1993 • 482 citations

A simple p53 functional assay for screening cell lines, blood, and tumors.

1995 • 447 citations

Molecular epidemiology of human cancer: contribution of mutation spectra studies of tumor suppressor genes.

1998 • 408 citations

The chemistry and biology of aflatoxin B1: from mutational spectrometry to carcinogenesis

2001 • 351 citations

Screening patients for heterozygous p53 mutations using a functional assay in yeast

1993 • 236 citations

p53 alterations in human cancer: more questions than answers

2007 • 233 citations

Dominant role of hepatitis B virus and cofactor role of aflatoxin in hepatocarcinogenesis in Qidong, China

2002 • 227 citations

Aflatoxin B1-induced DNA adduct formation and p53 mutations in CYP450- expressing human liver cell lines

1997 • 217 citations

The aflatoxin B ₁ formamidopyrimidine adduct plays a major role in causing the types of mutations observed in human hepatocellular carcinoma

2002 • 202 citations

trans-Lesion Synthesis Past Bulky Benzo[a]pyrene Diol Epoxide N2-dG and N6-dA Lesions Catalyzed by DNA Bypass Polymerases

2002 • 197 citations

Aflatoxin exposures in the industrial setting: An epidemiological study of mortality

1984 • 188 citations

Mycoflora and Multimycotoxin Detection in Corn Silage: Experimental Study

2006 • 177 citations

Mutational properties of the primary aflatoxin B1-DNA adduct.

1996 • 164 citations

Mutations of the p53 tumor suppressor gene and ras oncogenes in aflatoxin hepatocarcinogenesis

1996 • 163 citations

Carcinogens preferentially bind at methylated CpG in the p53 mutational hot spots.

1998 • 144 citations

Efficient activation of aflatoxin B₁ by cytochrome P450 2A13, an enzyme predominantly expressed in human respiratory tract

2005 • 127 citations

Sequence specificity in aflatoxin B1--DNA interactions.

1983 • 121 citations

Molecular epidemiology and carcinogenesis: endogenous and exogenous carcinogens

2000 • 120 citations

Tumourigenesis associated with the p53 tumour suppressor gene

1993 • 115 citations

Mapping the binding site of aflatoxin B1 in DNA: systematic analysis of the reactivity of aflatoxin B1 with guanines in different DNA sequences

1988 • 104 citations

Aflatoxin inhalation and alveolar cell carcinoma.

1976 • 91 citations

Biotransformation of aflatoxin B₁ in human lung

1996 • 80 citations

Activation of the c-Ki-ras oncogene in aflatoxin B1-induced hepatocellular carcinoma and adenoma in the rat: detection by denaturing gradient gel electrophoresis.

1993 • 66 citations

MECHANISMS OF AFLATOXIN B₁LUNG TUMORIGENESIS

2000 • 66 citations

Retroviral expression of the hepatitis B virus x gene promotes liver cell susceptibility to carcinogen-induced site specific mutagenesis

2000 • 65 citations

Quantitation and mapping of aflatoxin B1-induced DNA damage in genomic DNA using aflatoxin B1-8,9-epoxide and microsomal activation systems

1999 • 64 citations

Covalent and noncovalent interactions of aflatoxin with defined deoxyribonucleic acid sequences

1983 • 54 citations

Activation of K-ras in aflatoxin B₁-induced lung tumors from AC3F1 (A/J×C3H/HeJ) mice

1996 • 47 citations

High frequency and heterogeneous distribution of p53 mutations in aflatoxin B1-induced mouse lung tumors.

1999 • 41 citations

Acetaldehyde-induced mutational pattern in the tumour suppressor gene TP53 analysed by use of a functional assay, the FASAY (functional analysis of separated alleles in yeast)

2007 • 33 citations

Does aflatoxin as an environmental mycotoxin adversely affect the renal and hepatic functions of Egyptian lactating mothers and their infants? A preliminary report

2006 • 30 citations

Base and sequence specificities of aflatoxin B₁ binding to single- and double-stranded DNAs

1990 • 28 citations

In vitro aflatoxin B1-induced p53 mutations

2003 • 28 citations

Aflatoxin levels in sera of healthy first time rural blood donors: preliminary report

1981 • 16 citations

Quantitative and qualitative characterization of aflatoxin B1 adducts formed in vivo within the ribosomal RNA genes of rat liver DNA.

1985 • 12 citations

Codon 249 of the human TP53 tumor suppressor gene is no hot spot for aflatoxin B1 in a heterologous background

1999 • 8 citations