Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron

A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis

1996 • 3,682 citations

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

1997 • 3,130 citations

Hepcidin, a Urinary Antimicrobial Peptide Synthesized in the Liver

2001 • 2,140 citations

Disorders of Iron Metabolism

1999 • 2,062 citations

A New Mouse Liver-specific Gene, Encoding a Protein Homologous to Human Antimicrobial Peptide Hepcidin, Is Overexpressed during Iron Overload

2001 • 1,673 citations

Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

2000 • 1,624 citations

The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

2002 • 1,414 citations

A Novel Duodenal Iron-Regulated Transporter, IREG1, Implicated in the Basolateral Transfer of Iron to the Circulation

2000 • 1,413 citations

Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein

2003 • 1,392 citations

LEAP‐1, a novel highly disulfide‐bonded human peptide, exhibits antimicrobial activity

2000 • 1,313 citations

A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism

2000 • 1,259 citations

Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 ( USF2 ) knockout mice

2001 • 1,212 citations

Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

1997 • 1,178 citations

The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation

2002 • 1,167 citations

Severe iron deficiency anemia in transgenic mice expressing liver hepcidin

2002 • 888 citations

Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis

2002 • 872 citations

The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding

1998 • 852 citations

The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22

2000 • 816 citations

Molecular Cloning of Transferrin Receptor 2

1999 • 638 citations

Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease

2002 • 638 citations

Hepatic Iron Concentration and Total Body Iron Stores in Thalassemia Major

2000 • 556 citations

HFE gene knockout produces mouse model of hereditary hemochromatosis

1998 • 535 citations

Autosomal-dominant hemochrom-atosis is associated with a mutation in the ferroportin (SLC11A3) gene

2001 • 499 citations

A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis

2001 • 494 citations

The Hemochromatosis Founder Mutation in HLA-H Disrupts β2-Microglobulin Interaction and Cell Surface Expression

1997 • 481 citations

Autosomal-dominant hemochrom-atosis is associated with a mutation in the ferroportin (SLC11A3) gene

2001 • 451 citations

Hereditary hemochromatosis: Effects of C282Y and H63D mutations on association with β ₂ -microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells

1997 • 388 citations

Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats

2002 • 340 citations

The discovery of the new haemochromatosis gene

2003 • 334 citations

Transferrin receptor 2: Continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis

2000 • 276 citations

The C282Y Mutation Causing Hereditary Hemochromatosis Does Not Produce a Null Allele

1999 • 274 citations

C/EBPα Regulates Hepatic Transcription of Hepcidin, an Antimicrobial Peptide and Regulator of Iron Metabolism

2002 • 246 citations

Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis

2002 • 241 citations

Managed care for viruses

1997 • 203 citations

Defective iron homeostasis in beta 2-microglobulin knockout mice recapitulates hereditary hemochromatosis in man.

1996 • 197 citations

Iron homeostasis: new tales from the crypt

2000 • 181 citations

Molecular characterization of a case of atransferrinemia

2000 • 167 citations

Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosis

2002 • 145 citations

Regulation of expression of murine transferrin receptor 2

2001 • 143 citations

Physiology of iron transport and the hemochromatosis gene

2002 • 138 citations

Determination of non-transferrin-bound iron in genetic hemochromatosis using a new HPLC-based method

2000 • 117 citations

Transferrin receptor 2 (TfR2) and HFE mutational analysis in non-C282Y iron overload: identification of a novel TfR2 mutation

2002 • 113 citations

Relationship between intestinal iron-transporter expression, hepatic hepcidin levels and the control of iron absorption

2002 • 104 citations

Serum non‐transferrin‐bound iron in beta‐thalassaemia major patients treated with desferrioxamine and L1

1992 • 103 citations

A Fluorescence-Based One-Step Assay for Serum Non-Transferrin-Bound Iron

2001 • 103 citations

Liver iron concentration and distribution in chronic hepatitis C before and after interferon treatment.

1997 • 95 citations

HFE Downregulates Iron Uptake From Transferrin and Induces Iron-Regulatory Protein Activity in Stably Transfected Cells

1999 • 92 citations

IRON-INDUCED LIVER INJURY

2000 • 75 citations

Molecular aspects of iron absorption: Insights into the role of HFE in hemochromatosis

2002 • 60 citations

Bleomycin-detectable Iron Assay for Non-Transferrin-bound Iron in Hematologic Malignancies

2002 • 57 citations

Importance of Anemia and Transferrin Levels in the Regulation of Intestinal Iron Absorption in Hypotransferrinemic Mice

1999 • 49 citations

Intestinal iron absorption studies in mouse models of iron‐overload

1994 • 38 citations

Iron overload in viral and alcoholic liver disease

1998 • 29 citations