C-reactive protein, inflammation, and coronary risk

Atherosclerosis — An Inflammatory Disease

1999 • 21,494 citations

Beyond Cholesterol

1989 • 6,533 citations

Inflammation, Aspirin, and the Risk of Cardiovascular Disease in Apparently Healthy Men

1997 • 5,442 citations

Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques.

1994 • 2,497 citations

Molecular Bases of the Acute Coronary Syndromes

1995 • 2,049 citations

Plaque fissuring--the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina.

1985 • 2,003 citations

C-Reactive Protein, a Sensitive Marker of Inflammation, Predicts Future Risk of Coronary Heart Disease in Initially Healthy Middle-Aged Men

1999 • 1,952 citations

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

1989 • 1,914 citations

Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology.

1994 • 1,913 citations

Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes

1989 • 1,715 citations

Endothelial Expression of a Mononuclear Leukocyte Adhesion Molecule During Atherogenesis

1991 • 1,703 citations

Prospective Study of C-Reactive Protein and the Risk of Future Cardiovascular Events Among Apparently Healthy Women

1998 • 1,668 citations

Production of C-reactive protein and risk of coronary events in stable and unstable angina

1997 • 1,515 citations

Long-Term Effects of Pravastatin on Plasma Concentration of C-reactive Protein

1999 • 1,488 citations

Inflammation, Pravastatin, and the Risk of Coronary Events After Myocardial Infarction in Patients With Average Cholesterol Levels

1998 • 1,398 citations

Acute Phase Proteins with Special Reference to C-Reactive Protein and Related Proteins (Pentaxins) and Serum Amyloid A Protein

1983 • 1,283 citations

INFLUENCE OF PLAQUE CONFIGURATION AND STRESS DISTRIBUTION ON FISSURING OF CORONARY ATHEROSCLEROTIC PLAQUES

1989 • 1,249 citations

Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men

1998 • 1,238 citations

Localization of tissue factor in the normal vessel wall and in the atherosclerotic plaque.

1989 • 1,233 citations

Macrophage infiltration in acute coronary syndromes. Implications for plaque rupture.

1994 • 1,125 citations

Relation of C-Reactive Protein and Coronary Heart Disease in the MRFIT Nested Case-Control Study

1996 • 1,106 citations

C-Reactive Protein Adds to the Predictive Value of Total and HDL Cholesterol in Determining Risk of First Myocardial Infarction

1998 • 1,033 citations

Hemodynamics and atherosclerosis. Insights and perspectives gained from studies of human arteries.

1988 • 1,024 citations

Plaque rupture with severe pre-existing stenosis precipitating coronary thrombosis. Characteristics of coronary atherosclerotic plaques underlying fatal occlusive thrombi.

1983 • 1,023 citations

Plasma Concentration of C-Reactive Protein and Risk of Developing Peripheral Vascular Disease

1998 • 987 citations

Antiatherothrombotic Properties of Statins

1998 • 972 citations

Reduction of atherosclerosis in mice by inhibition of CD40 signalling

1998 • 917 citations

Upregulation of VCAM-1 and ICAM-1 at Atherosclerosis-Prone Sites on the Endothelium in the ApoE-Deficient Mouse

1998 • 890 citations

Leukocyte adhesion to endothelium in inflammation

1990 • 882 citations

C Reactive protein and its relation to cardiovascular risk factors: a population based cross sectional study

1996 • 869 citations

Lewis A. Conner Memorial Lecture. Mechanisms leading to myocardial infarction: insights from studies of vascular biology.

1994 • 862 citations

Relationship of C-Reactive Protein to Risk of Cardiovascular Disease in the Elderly

1997 • 838 citations

Variability in the measurement of C-reactive protein in healthy subjects: implications for reference intervals and epidemiological applications

1997 • 814 citations

Angiographie morphology and the pathogenesis of unstable angina pectoris

1985 • 811 citations

Syndromes of accelerated atherosclerosis: Role of vascular injury and smooth muscle cell proliferation

1990 • 765 citations

Elevated Levels of Interleukin-6 in Unstable Angina

1996 • 744 citations

Evolution and progression of atherosclerotic lesions in coronary arteries of children and young adults.

1989 • 740 citations

Statins do more than just lower cholesterol

1996 • 714 citations

Cytokine regulation of endothelial cell function

1992 • 684 citations

Interleukin-1 Mitogenic Activity for Fibroblasts and Smooth Muscle Cells Is Due to PDGF-AA

1989 • 648 citations

Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion.

1994 • 644 citations

Elevation of C-reactive protein in “active” coronary artery disease

1990 • 592 citations

Cytokines and growth factors positively and negatively regulate interstitial collagen gene expression in human vascular smooth muscle cells.

1991 • 591 citations

Expression of intercellular adhesion molecule-1 in atherosclerotic plaques.

1992 • 585 citations

Shear stress selectively upregulates intercellular adhesion molecule-1 expression in cultured human vascular endothelial cells.

1994 • 576 citations

The Unstable Atheroma

1997 • 568 citations

Interleukin 1: a mitogen for human vascular smooth muscle cells that induces the release of growth-inhibitory prostanoids.

1988 • 519 citations

Activation of Monocyte/Macrophage Functions Related to Acute Atheroma Complication by Ligation of CD40

1997 • 493 citations

Specific platelet mediators and unstable coronary artery lesions. Experimental evidence and potential clinical implications.

1989 • 461 citations

Plaque fissures in human coronary thrombosis

1966 • 424 citations

The frequency and significance of coronary arterial thrombi and other observations in fatal acute myocardial infarction

1972 • 419 citations

A macro and micro view of coronary vascular insult in ischemic heart disease.

1990 • 411 citations

TNF-alpha and IL-1beta selectively induce expression of 92-kDa gelatinase by human macrophages.

1996 • 409 citations

Cytokine-stimulated human vascular smooth muscle cells synthesize a complement of enzymes required for extracellular matrix digestion.

1994 • 408 citations

Why do plaques rupture?

1992 • 385 citations

Macrophages, Smooth Muscle Cells, and Tissue Factor in Unstable Angina

1996 • 357 citations

Interleukin-6 and interleukin-8 protein and gene expression in human arterial atherosclerotic wall

1996 • 336 citations

Production of Platelet-Derived Growth Factor–like Mitogen by Smooth-Muscle Cells from Human Atheroma

1988 • 333 citations

Analytical Evaluation of Particle-Enhanced Immunonephelometric Assays for C-Reactive Protein, Serum Amyloid a and Mannose-Binding Protein in Human Serum

1998 • 322 citations

Chronic treatment with interleukin-1 beta induces coronary intimal lesions and vasospastic responses in pigs in vivo. The role of platelet-derived growth factor.

1996 • 283 citations

Identification and distribution of fibrinogen, fibrin, and fibrin(ogen) degradation products in atherosclerosis. Use of monoclonal antibodies.

1989 • 269 citations

Homocysteine and Risk of Cardiovascular Disease Among Postmenopausal Women

1999 • 260 citations

Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic fatty streak formation in mice.

1994 • 228 citations

Significance of adventitial inflammation of the coronary artery in patients with unstable angina: results at autopsy.

1985 • 226 citations

Interleukin 6 stimulates growth of vascular smooth muscle cells in a PDGF-dependent manner

1991 • 226 citations

Transient intermittent lymphocyte activation is responsible for the instability of angina.

1992 • 220 citations

Monocytic origin of foam cells in human atherosclerotic plaques

1984 • 202 citations

Human vascular smooth muscle cells both express and respond to heparin-binding growth factor I (endothelial cell growth factor).

1987 • 194 citations

Identification and distribution of fibrinogen, fibrin and fibrin (ogen) degradation products in atherosclerosis

1989 • 168 citations

ASSOCIATION OF CORONARY PLAQUE RUPTURE AND ATHEROSCLEROTIC INFLAMMATION

1997 • 140 citations

MACROPHAGES AND ATHEROGENESIS

1987 • 134 citations

Expression of Interleukin-6 in Atherosclerotic Lesions of Male ApoE-Knockout Mice

1998 • 127 citations

Rapid Automated High Sensitivity Enzyme Immunoassay of C-Reactive Protein

1998 • 126 citations

Common mechanisms of proliferation of smooth muscle in atherosclerosis and hypertension

1987 • 122 citations

Prospective studies of C-reactive protein as a risk factor for cardiovascular disease.

1998 • 118 citations

Effects of different inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, pravastatin sodium and simvastatin, on sterol synthesis and immunological functions in human lymphocytes in vitro

1996 • 99 citations

Inhibition of human vascular smooth muscle cell proliferation by lovastatin: the role of isoprenoid intermediates of cholesterol synthesis

1994 • 89 citations

Non-Lipid-Related Effects of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Inhibitors

1996 • 88 citations

Genetic manipulation of vascular adhesion molecules in mice.

1996 • 72 citations

Monocyte adhesion and transmigration in atherosclerosis

1994 • 62 citations

Effects of flwastatin on growth of porcine and human vascular smooth muscle cells in vitro

1995 • 48 citations

Effect of Active Oxygen Species on Intimal Proliferation in Rat Aorta after Arterial Injury

1996 • 43 citations