HIV-1 gp120 Modulates Hypothalamic Cytokine mRNAsin Vivo:Implications to Cytokine Feedback Systems

Biologic basis for interleukin-1 in disease

1996 • 4,324 citations

A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples.

1993 • 2,807 citations

Molecular Cloning and Characterization of a Second Subunit of the Interleukin 1 Receptor Complex

1995 • 634 citations

Interleukin 1 signaling occurs exclusively via the type I receptor.

1993 • 609 citations

Cytokine expression in the brain during the acquired immunodeficiency syndrome

1992 • 572 citations

Transforming growth factor-beta suppresses activation and proliferation of microglia in vitro.

1993 • 303 citations

Human immunodeficiency virus type 1 (HIV-1) infection of the central nervous system: an evaluation of cytokines in cerebrospinal fluid

1989 • 259 citations

Interleukin 1 signaling occurs exclusively via the typeI receptor

1993 • 228 citations

gp120-Induced Neurotoxicity in Hippocampal Pyramidal Neuron Cultures: Protective Action of TGF-β1

1996 • 204 citations

The HIV envelope protein gp120 is toxic to human brain-cell cultures through the induction of interleukin-6 and tumor necrosis factor-α

1995 • 169 citations

Human immunodeficiency virus 1 envelope proteins induce interleukin 1, tumor necrosis factor alpha, and nitric oxide in glial cultures derived from fetal, neonatal, and adult human brain.

1995 • 154 citations

Anorexia induced by chronic central administration of cytokines at estimated pathophysiological concentrations

1996 • 152 citations

The HIV envelope protein gp120 is toxic to human brain-cell cultures through the induction of interleukin-6 and tumor necrosis factor-α

1995 • 150 citations

E1a transactivation of the human HSP70 promoter is mediated through the basal transcriptional complex.

1989 • 147 citations

Glial cell-specific mechanisms of TGF-β1 induction by IL-1 in cerebral cortex

1993 • 142 citations

Interleukin-1β inhibits Ca2+ channel currents in hippocampal neurons through protein kinase C

1994 • 136 citations

Human Immunodeficiency Virus and the Brain

1996 • 110 citations

Meal patterns in response to the intracerebroventricular administration of interleukin-1β in rats

1994 • 96 citations

HIV, AIDS, And the Brain

1994 • 88 citations

Human immunodeficiency virus glycoprotein (gp120) infused into rat brain induces interleukin 1 to elevate pituitary-adrenal activity and decrease peripheral cellular immune responses.

1991 • 86 citations

Investigation on the expression of major histocompatibility complex class II and cytokines and detection of HIV-1 DNA within brains of asymptomatic and symptomatic HIV-1-positive patients

1996 • 59 citations

HIV‐1 envelope glycoprotein gp120 down‐regulates CD4 expression in primary human macrophages through induction of endogenous tumour necrosis factor‐α

1996 • 42 citations

Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons

1996 • 41 citations

In Vivo Regulation of the IL-1β System (Ligand, Receptors I and II, Receptor Accessory Protein, and Receptor Antagonist) and TNF-α mRNAs in Specific Brain Regions

1996 • 38 citations

Interleukin 1 binding to its type I, but not type II receptor, modulates the in vivo acute phase response

1995 • 34 citations

The type I interleukin-1 receptor mediates fever in the rat as shown by interleukin-1 receptor subtype selective ligands

1995 • 30 citations

The synthesis of IL-1 receptor antagonist (IL-1ra) by synovial fibroblasts is markedly increased by the cytokines TNF-α and IL-1

1993 • 27 citations

Differential effects of transforming growth factor-β1 on interleukin-1-induced cellular inflammation and vascular permeability in the rabbit retina

1996 • 19 citations

Regulation of brain interleukin-1β (IL-1β) system mRNAs in response to pathophysiological concentrations of IL-1β in the cerebrospinal fluid

1996 • 19 citations

The role of cytokines in the acquired immunodeficiency syndrome

1995 • 13 citations