Conversion of truncated and elongated prion proteins into the scrapie isoform in cultured cells.

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Molecular Biology of Prion Diseases

1991 • 1,978 citations

Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

1992 • 1,632 citations

A cellular gene encodes scrapie PrP 27-30 protein

1985 • 1,494 citations

Scrapie prion protein contains a phosphatidylinositol glycolipid

1987 • 1,104 citations

Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication

1990 • 874 citations

Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene

1986 • 829 citations

Mouse polyclonal and monoclonal antibody to scrapie-associated fibril proteins

1987 • 757 citations

Glycosyl-Phosphatidylinositol Moiety That Anchors Trypanosoma brucei Variant Surface Glycoprotein to the Membrane

1988 • 701 citations

Transgenic mice expressing hamster prion protein produce species-specific scrapie infectivity and amyloid plaques

1989 • 696 citations

The scrapie-associated form of PrP is made from a cell surface precursor that is both protease- and phospholipase-sensitive.

1991 • 627 citations

Separation and properties of cellular and scrapie prion proteins.

1986 • 619 citations

Spontaneous Neurodegeneration in Transgenic Mice with Mutant Prion Protein

1990 • 531 citations

Scrapie and cellular prion proteins differ in their kinetics of synthesis and topology in cultured cells.

1990 • 510 citations

Purification and structural studies of a major scrapie prion protein

1984 • 497 citations

N-terminal truncation of the scrapie-associated form of PrP by lysosomal protease(s): implications regarding the site of conversion of PrP to the protease-resistant state

1991 • 412 citations

Transmissible familial Creutzfeldt-Jakob disease associated with five, seven, and eight extra octapeptide coding repeats in the PRNP gene.

1991 • 328 citations

Predicted alpha-helical regions of the prion protein when synthesized as peptides form amyloid.

1992 • 327 citations

Scrapie prion proteins accumulate in the cytoplasm of persistently infected cultured cells.

1990 • 279 citations

Glycosylinositol Phospholipid Anchors of the Scrapie and Cellular Prion Proteins Contain Sialic Acid

1992 • 278 citations

Synthesis and trafficking of prion proteins in cultured cells.

1992 • 268 citations

Chimeric prion protein expression in cultured cells and transgenic mice

1992 • 240 citations

Prion dementia without characteristic pathology

1990 • 230 citations

Replication of distinct scrapie prion isolates is region specific in brains of transgenic mice and hamsters.

1992 • 213 citations

Turn prediction in proteins using a pattern-matching approach

1986 • 212 citations

Purification and properties of the cellular prion protein from Syrian hamster brain

1992 • 187 citations

Acquisition of protease resistance by prion proteins in scrapie-infected cells does not require asparagine-linked glycosylation.

1990 • 170 citations

INHERITED PRION DISEASE WITH 144 BASE PAIR GENE INSERTION: 2. CLINICAL AND PATHOLOGICAL FEATURES

1992 • 169 citations

INHERITED PRION DISEASE WITH 144 BASE PAIR GENE INSERTION: 1. GENEALOGICAL AND MOLECULAR STUDIES

1992 • 168 citations

An in-frame insertion in the prion protein gene in familial Creutzfeldt-Jakob disease

1990 • 148 citations

DIAGNOSIS OF GERSTMANN-STRÄUSSLER SYNDROME IN FAMILIAL DEMENTIA WITH PRION PROTEIN GENE ANALYSIS

1989 • 148 citations

Paradoxical shortening of scrapie incubation times by expression of prion protein transgenes derived from long incubation period mice

1991 • 136 citations

Epitope mapping of the Syrian hamster prion protein utilizing chimeric and mutant genes in a vaccinia virus expression system.

1991 • 107 citations

A dementing illness associated with a novel insertion in the prion protein gene

1992 • 93 citations

Intracellular accumulation of the cellular prion protein after mutagenesis of its Asnlinked glycosylation sites

1990 • 82 citations

Deletion in prion protein gene in a Moroccan family

1990 • 58 citations

Human alpha 2(VI) collagen gene. Heterogeneity at the 5'-untranslated region generated by an alternate exon.

1992 • 55 citations

Prion protein gene expression in cultured cells

1988 • 48 citations

Adenovirus E4-dependent activation of the early E2 promoter is insufficient to promote the early-to-late-phase transition

1991 • 47 citations

Insertions in the prion protein gene in atypical dementias

1991 • 46 citations

Molecular and cell biology of membrane proteins

1991 • 21 citations